Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79501 | Target Info | |||
| Target Name | Protein arginine methyltransferase 7 (PRMT7) | ||||
| Synonyms |
Protein arginine N-methyltransferase 7; KIAA1933; Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PRMT7 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(L-)-S-adenosyl-L-homocysteine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
S-Adenosyl-L-homocysteine; S-adenosylhomocysteine; S-adenosyl-L-homocysteine; 979-92-0; AdoHcy; S-(5'-adenosyl)-L-homocysteine; adenosylhomocysteine; Formycinylhomocysteine; Adenosyl-L-homocysteine; S-(5'-deoxyadenosin-5'-yl)-L-homocysteine; 2-S-adenosyl-L-homocysteine; 5'-Deoxy-S-adenosyl-L-homocysteine; S-adenosyl-homocysteine; S-Adenosyl Homocysteine; L-S-Adenosylhomocysteine; L-Homocysteine, S-(5'-deoxyadenosin-5'-yl)-; adenosylhomo-cys; adenosyl-homo-cys; UNII-8K31Q2S66S; (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine; BRN 5166233; SAH; S-Adenosylhomocysteine; S-Adenosyl-L-Homocysteine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[(3-Bromophenyl)methyl]-1-[2-(methylamino)ethyl]piperidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-Benzyl-1-[2-(methylamino)ethyl]piperidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DS-437; CHEMBL3577854; EX-A3697; BDBM50089221; HY-124131; CS-0084441
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 2-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PRMT5-IN-C17; ZINC00659298; ChemDiv1_002844; Oprea1_645106; CHEMBL4092336; HMS595B06; ZINC5455374; STK346078; AKOS000421473; AKOS000830714; MCULE-9755352312; AG-690/12869587; SR-01000429953; SR-01000429953-1; Z16078172; methyl 2-({[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoate; methyl 2-({[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoate; methyl 2-{2-[(6-methoxy-1H-1,3-benzodiazol-2-yl)sulfanyl]acetamido}benzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12. | ||||
| REF 2 | Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1). Medchemcomm. 2016 Sep 1;7(9):1793-1796. | ||||
| REF 3 | Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017 Jul 27;60(14):6289-6304. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.