Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79326 | Target Info | |||
| Target Name | Ketohexokinase (KHK) | ||||
| Synonyms |
Hepatic fructokinase
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| Target Type | Literature-reported Target | ||||
| Gene Name | KHK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[3-Methylsulfanyl-6-(piperazin-1-ylmethyl)indazol-1-yl]aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666154; SCHEMBL16712528; BDBM130630; US8822447, 115
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| Activity |
IC50 ~ 51000 nM
|
[1] | |||
| Compound Name |
[3-Methylsulfanyl-1-(4-nitrophenyl)indazol-6-yl]-piperazin-1-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2564804; CHEMBL3666163; BDBM130639; US8822447, 133
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| Activity |
IC50 ~ 51000 nM
|
[1] | |||
| Compound Name |
3-(Trifluoromethyl)quinoxalin-2-ol
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Investigative | Compound Info | ||
| Synonyms |
2-Hydroxy-3-(trifluoromethyl)quinoxalin; 3-(trifluoromethyl)quinoxalin-2(1H)-one; 3-(trifluoromethyl)-1H-quinoxalin-2-one; 3-Trifluoromethyl-1H-quinoxalin-2-one; 2(1H)-Quinoxalinone,3-(trifluoromethyl)-; CHEMBL1463512; 2(1H)-Quinoxalinone, 3-(trifluoromethyl)-; CDS1_000049; Maybridge1_002337; Bionet2_000796; trifluoromethyl quinoxalinone; MLS000777386; DivK1c_001089; SCHEMBL2131608; SCHEMBL12794446; CTK5A8338; CTK8J4628; HMS548C05; KS-00001PTQ; DTXSID50346389; HMS1366E04; HMS2767H20; ZINC8873813; BDBM50241205; MFCD00243991; SBB094920; STK363108; STK857607; 2-hydroxy-3-trifluoromethylquinoxaline; AKOS001312151; AKOS005632195; CCG-236058; MCULE-8591204262; VZ24719; 2-Hydroxy-3-(trifluoromethyl)quinoxaline; 3-(trifluoromethyl)hydroquinoxalin-2-one; SMR000413825; ST044804; 3-(Trifluoromethyl)quinoxaline-2(1H)-one; DB-021160; 3-(Trifluoromethyl)-2(1H)-quinoxalinone #; FT-0640527; EN300-26302; 9J-050; 3-(trifluoromethyl)-1,2-dihydroquinoxalin-2-one; A831886; SR-01000512963; 2-hydroxy-3-(trifluoromethyl)quinoxalin, AldrichCPR; J-511035; SR-01000512963-1; BRD-K67657540-001-08-2; Z223042396
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
[(3r)-1-(5-Methyl-7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)piperidin-3-Yl]methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086173; BDBM50241207; A4G
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| Activity |
IC50 = 118000 nM
|
[2] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4,6-Dimethyl-2-(morpholin-4-yl)pyridine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
4,6-dimethyl-2-morpholinonicotinonitrile; CHEMBL1500542; 4,6-dimethyl-2-(4-morpholinyl)nicotinonitrile; 4,6-dimethyl-2-morpholin-4-ylpyridine-3-carbonitrile; F1739-0001; MLS000528486; Bionet2_001271; 4,6-Dimethyl-2-morpholin-4-yl-nicotinonitrile; CTK7C6313; HMS1367J17; HMS2293E19; CCG-1453; KS-00001W2V; BDBM50241206; MFCD00124668; SBB095447; STK953726; ZINC19117525; AKOS000670159; MCULE-2207481181; SMR000121061; ST50016394; 3W-0874; AO-476/40921698; 4,6-DIMETHYL-2-MORPHOLIN-4-YLNICOTINONITRILE; BRD-K32970645-001-08-5; Z57724234
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| Activity |
IC50 = 316227.77 nM
|
[2] | |||
| Compound Name |
6-Amino-2-chloro-5-fluoronicotinonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074975; SCHEMBL9967116; BDBM50241201; AKOS026717690; ZINC141757026; 6-amino-2-chloro-5-fluoropyridine-3-carbonitrile; F2147-5203
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 8822447B2, Indazole compounds useful as ketohexokinase inhibitors | ||||
| REF 2 | Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). J Med Chem. 2017 Sep 28;60(18):7835-7849. | ||||
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