Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79232 | Target Info | |||
| Target Name | Vasopressin V1a receptor (V1AR) | ||||
| Synonyms |
Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a
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| Target Type | Successful Target | ||||
| Gene Name | AVPR1A | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
GSK137647A; GSK 137647; GSK-137647A; N-mesityl-4-methoxybenzenesulfonamide; CHEMBL3311308; MFCD02007969; 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide; CBMicro_012617; Oprea1_349531; Oprea1_545891; SCHEMBL19357604; KS-00000TIW; AOB2991; ZINC184126; BCP17136; EX-A1097; GSK 137647A; SMSF0014079; BDBM50044849; STK899558; AKOS003261220; CB15818; CS-5549; GSK-137647; MCULE-5583867808; N-mesityl-4-methoxy-1-benzenesulfonamide; NCGC00387253-02; NCGC00387253-05; AK240703; AS-16737; HY-19995; BIM-0012523.P001; FFA4 (GPR120) agonist GSK137647A; B7793; EU-0076636; FT-0700296; S0001; ST50719559; GSK137647A, >=98% (HPLC); A14542; AJ-292/14925630; SR-01000478738; J-690285; SR-01000478738-1; [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine; 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide; 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
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| Activity |
IC50 ~ 50118.72 nM
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[1] | |||
| Compound Name |
CID 44247566
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223262; SCHEMBL4307007; BDBM50416620
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| Activity |
IC50 ~ 50118.72 nM
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[2] | |||
| Compound Name |
CID 44467347
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223261; SCHEMBL4309808; BDBM50416619
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| Activity |
IC50 ~ 50118.72 nM
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[2] | |||
| Compound Name |
2-[6-[4-Fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-(3-piperidin-1-ylpropoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223473; SCHEMBL4302720; BDBM50416627
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| Activity |
IC50 ~ 50118.72 nM
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[2] | |||
| Compound Name |
Dilithium;3-amino-9-[4-[[(5S)-5-[[(2S)-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-19-hydroxy-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-6-(carboxymethylamino)-6-oxohexyl]carbamoyl]-2-carboxyphenyl]-6-iminoxanthene-4,5-disulfonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765670
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| Activity |
Ki = 55300 nM
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[3] | |||
| Compound Name |
Benzyl 2-((3S,4R)-3-(1,3-dioxoisoindolin-2-yl)-2-oxo-4-((E)-styryl)azetidin-1-yl)-2-(2-methyl-1,3-dioxolan-2-yl)acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396271; BDBM50202876
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| Activity |
IC50 = 61000 nM
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[4] | |||
| Compound Name |
1-[1-[4-[3-(Acetylamino)propoxy]benzoyl]piperidin-4-yl]-3,4-dihydroquinazolin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL143341; BDBM50029645; N-(3-{4-[4-(2-Oxo-3,4-dihydro-2H-quinazolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-propyl)-acetamide
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| Activity |
Ki = 62000 nM
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[5] | |||
| Compound Name |
Vasopressin antagonist 1867
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684573; N-isopropyl-2-(2-(3-methoxyphenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)acetamide; Compound 12i; SCHEMBL3114804; BDBM50338810; ZINC38228094; 2-[2-(3-methoxyphenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)quinazolin-3-yl]-N-propan-2-ylacetamide
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
2-(2-(3-Chlorophenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)-N-isopropylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684574; SCHEMBL3116140; BDBM50338811; 2-(3-Chlorophenyl)-N-(1-methylethyl)-4-oxo-6-[3-(1-piperidinyl)propoxy]-3(4H)-quinazolineacetamide; 2-[2-(3-Chlorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide; 2-[2-(3-chlorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)quinazolin-3-yl]-N-propan-2-ylacetamide
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(2,3-Dimethylphenyl)-N-ethyl-N-(6-methoxypyridin-3-yl)pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090654; BDBM50314512
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| Activity |
Ki = 472000 nM
|
[7] | |||
| Compound Name |
5-(2,3-Dimethylphenyl)-N-(2-methoxyethyl)-N-(6-methoxypyridin-3-yl)pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093599; BDBM50314514
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| Activity |
Ki = 539000 nM
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[7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. | ||||
| REF 2 | Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: novel, potent, and selective series of Vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5044-9. | ||||
| REF 3 | Design, synthesis, and pharmacological characterization of fluorescent peptides for imaging human V1b vasopressin or oxytocin receptors. J Med Chem. 2011 Apr 28;54(8):2864-77. | ||||
| REF 4 | Azetidinones as vasopressin V1a antagonists. Bioorg Med Chem. 2007 Mar 1;15(5):2054-80. | ||||
| REF 5 | 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem. 1995 Nov 10;38(23):4634-6. | ||||
| REF 6 | Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1871-5. | ||||
| REF 7 | Identification of amide bioisosteres of triazole oxytocin antagonists. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2224-8. | ||||
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