Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79068 | Target Info | |||
| Target Name | Bacterial Fatty acid synthetase I (Bact inhA) | ||||
| Synonyms |
Enoyl-[acyl-carrier-protein] reductase [NADH]; Bacterial InhA
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| Target Type | Successful Target | ||||
| Gene Name | Bact inhA | ||||
| Biochemical Class | CH-CH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 41 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-Benzhydryl-4-(4-fluorobenzoyl)piperazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393976; [4-(diphenylmethyl)piperazin-1-yl](4-fluorophenyl)methanone; Oprea1_658125; Oprea1_819176; (4-benzhydrylpiperazin-1-yl)-(4-fluorophenyl)methanone; BBL023893; BDBM50101453; STK020264; ZINC19907574; AKOS002284811; CCG-279023; MCULE-8237302036; ST50810166; (4-benzhydrylpiperazino)(4-fluorophenyl)methanone; AG-690/12885659; 4-(diphenylmethyl)piperazinyl 4-fluorophenyl ketone
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(E)-1-(4-Benzhydrylpiperazin-1-yl)-3-phenylprop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393978; SCHEMBL10744717; BDBM50101450; STK103569; ZINC19798739; AKOS003450427; MLS-0472350.0001; (E)-1-(4-benzhydrylpiperazin-1-yl)-3-phenyl-prop-2-en-1-one; 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-enoyl]piperazine; (2E)-1-[4-(diphenylmethyl)piperazin-1-yl]-3-phenylprop-2-en-1-one
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Benzhydryl-4-(phenylsulfonyl)piperazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL486730; 1-(diphenylmethyl)-4-(phenylsulfonyl)piperazine; TimTec1_000518; Oprea1_589491; Oprea1_596808; HMS1535H12; BDBM50101451; STL193404; ZINC19597025; AKOS000390657; MCULE-6887682474; ST008234; 1-(benzenesulfonyl)-4-benzhydryl-piperazine; EU-0084970; 1-(benzenesulfonyl)-4-(diphenylmethyl)piperazine; AG-205/11611414; SR-01000519664; SR-01000519664-1; BRD-K34942179-001-01-1; Z44543532; F0777-0890
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Benzyl-4-(9H-fluoren-9-yl)piperazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393971; BDBM50101489
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(4-Benzhydrylpiperazin-1-yl)-(4-methoxyphenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393973; CBDivE_013954; Oprea1_211923; SCHEMBL4750736; BDBM50101477; STK364397; ZINC19300163; AKOS001268208; MCULE-7236916462; ST45140671; AH-357/03479022; 4-(diphenylmethyl)piperazinyl 4-methoxyphenyl ketone; [4-(diphenylmethyl)piperazin-1-yl](4-methoxyphenyl)methanone; 4-[(4-benzhydryl-1-piperazinyl)carbonyl]phenyl methyl ether
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[4-(9H-Fluoren-9-yl)piperazin-1-yl]-N-phenyl-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393970; BDBM50101565; AKOS006488494
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(E)-1-[4-(9H-Fluoren-9-yl)piperazin-1-yl]-3-phenylprop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393969; BDBM50101572; (E)-1-[4-(9H-fluoren-9-yl)piperazin-1-yl]-3-phenyl-prop-2-en-1-one
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(4-Benzhydrylpiperazin-1-yl)-(4-chlorophenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393975; TimTec1_001993; Oprea1_483909; HMS1539K13; BDBM50101454; STK408089; ZINC19597045; AKOS001152239; CCG-239417; MCULE-5599294165; ST024892; (4-benzhydrylpiperazino)(4-chlorophenyl)methanone; 4-(diphenylmethyl)piperazinyl 4-chlorophenyl ketone; BRD-K59597642-001-01-2; (4-chlorophenyl)[4-(diphenylmethyl)piperazin-1-yl]methanone
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(2-Propyl-4-pyridyl)-4-(4-pyridyl)thiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319431; BDBM50047690
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2,5-Difluorophenyl)[4-(diphenylmethyl)piperazin-1-yl]methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393977; BDBM50101452; STL199204; ZINC21866780; AKOS001069785; MCULE-2964338908; (4-benzhydrylpiperazin-1-yl)-(2,5-difluorophenyl)methanone
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[4-(9H-Fluoren-9-yl)piperazin-1-yl]-(4-nitrophenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393960; BDBM50101581
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(9H-Fluoren-9-yl)-4-(o-tolylsulfonyl)piperazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393968; BDBM50101573
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Chloro-N-(3,4-dichlorophenyl)-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL560606; ZINC102778; BDBM50297550; MFCD00586016; STK414328; AKOS003272388; CCG-340593; MCULE-6369555910; ST011034; N-(3,4-dichlorophenyl)(4-chloro-3-nitrophenyl)carboxamide
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| Activity |
IC50 = 52480 nM
|
[3] | |||
| Compound Name |
1-Cyclohexyl-N-(2,4-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
TimTec1_007534; CHEMBL217144; BDBM15667; HMS1555G10; ACT08636; Pyrrolidine Carboxamide Compound d1; STK168300; AKOS000340145; AKOS022086392; MCULE-8719569891; IDI1_033188; ST059488; SR-01000500523; SR-01000500523-1; 1-cyclohexyl-N-(2,4-dichlorophenyl)-5-oxo-3-pyrrolidinecarboxamide; 1-cyclohexyl-N-(2,4-dichlorophenyl)-5-oxo-pyrrolidine-3-carboxamide; N-(2,4-dichlorophenyl)(1-cyclohexyl-5-oxopyrrolidin-3-yl)carboxamide
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| Activity |
IC50 = 56020 nM
|
[4] | |||
| Compound Name |
1-Cyclohexyl-N-(2,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
N-(2,5-dichlorophenyl)(1-cyclohexyl-5-oxopyrrolidin-3-yl)carboxamide; CBMicro_043226; Oprea1_013597; Oprea1_807047; CHEMBL215081; BDBM15668; Pyrrolidine Carboxamide Compound d2; STK221181; AKOS003245233; MCULE-4759113609; ST059188; BIM-0043455.P001; 1-Cyclohexyl-N-(2,5-dichlorophenyl)-2-oxopyrrolidine-4-carboxamide; 1-Cyclohexyl-N-(2,5-dichlorophenyl)-5-oxo-3-pyrrolidinecarboxamide; 1-Cyclohexyl-N-(2,5-dichlorophenyl)-5-oxo-3-pyrrolidinecarboxamide #; 1-cyclohexyl-N-(2,5-dichlorophenyl)-5-oxo-pyrrolidine-3-carboxamide; 3-Pyrrolidinecarboxamide, 1-cyclohexyl-N-(2,5-dichlorophenyl)-5-oxo-
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| Activity |
IC50 = 56500 nM
|
[4] | |||
| Compound Name |
3-Hydroxy-N-[(2r,5r,6s,9s,10s,11r)-10-Hydroxy-5,11-Dimethyl-3,7,12-Trioxo-2-(Propan-2-Yl)-9-(Pyridin-3-Ylmethyl)-1,4-Dioxa-8-Azacyclododecan-6-Yl]pyridine-2-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323583; SCHEMBL15590312; BDBM50489465; Q27461326
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| Activity |
Ki = 71000 nM
|
[5] | |||
| Compound Name |
N-(4-Acetylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CBMicro_026197; CHEMBL217272; BDBM15664; Pyrrolidine Carboxamide Compound s17; STK227355; AKOS000590320; AKOS016521817; MCULE-2867537495; ST059481; BIM-0026143.P001; AB00090690-01; 1-cyclohexyl-N-(4-acetylphenyl)-5-oxopyrrolidine-3-carboxamide; N-(4-acetylphenyl)-1-cyclohexyl-5-oxo-3-pyrrolidinecarboxamide; N-(4-acetylphenyl)(1-cyclohexyl-5-oxopyrrolidin-3-yl)carboxamide; N-(4-acetylphenyl)-1-cyclohexyl-5-oxo-pyrrolidine-3-carboxamide
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| Activity |
IC50 = 73580 nM
|
[4] | |||
| Compound Name |
N-[3-(Acetylamino)phenyl]-1-cyclohexyl-5-oxo-3-pyrrolidinecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
MLS001060519; CHEMBL216781; BDBM15660; HMS1600F13; HMS2983D04; Pyrrolidine Carboxamide Compound s13; STK218159; AKOS003346093; MCULE-2373704613; SMR000669700; ST059221; 1-cyclohexyl-N-(3-acetamidophenyl)-5-oxopyrrolidine-3-carboxamide; N-(3-acetamidophenyl)-1-cyclohexyl-5-oxo-pyrrolidine-3-carboxamide; 3-Pyrrolidinecarboxamide, N-[3-(acetylamino)phenyl]-1-cyclohexyl-5-oxo-; N-[3-(acetylamino)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide; N-{3-[(1-cyclohexyl-5-oxopyrrolidin-3-yl)carbonylamino]phenyl}acetamide
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| Activity |
IC50 ~ 75000 nM
|
[4] | |||
| Compound Name |
Agonodepside A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL454588; BDBM50242321
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| Activity |
IC50 = 75000 nM
|
[6] | |||
| Compound Name |
4-(Tert-butyl)phenyl 4-(3-chlorophenyl)piperazinyl ketone
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Investigative | Compound Info | ||
| Synonyms |
[4-(tert-butyl)phenyl][4-(3-chlorophenyl)piperazino]methanone; piperazine, a10; Oprea1_295654; Oprea1_403956; CHEMBL239891; BDBM25781; CTK6H2692; KS-00003PKB; ZINC841253; MFCD01195456; STK128387; AKOS000677851; MCULE-1307829431; MS-7920; ST50697396; SR-01000426156; SR-01000426156-1; 1-(4-tert-butylbenzoyl)-4-(3-chlorophenyl)piperazine; 1-[(4-tert-butylphenyl)carbonyl]-4-(3-chlorophenyl)piperazine; (4-tert-butylphenyl)[4-(3-chlorophenyl)piperazin-1-yl]methanone
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-Bromophenyl)-1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216299; BDBM15706; Pyrrolidine Carboxamide Compound 3l; STK162747; AKOS000339446; AKOS022084464; MCULE-9995571072; SR-01000269650; SR-01000269650-1; N-(3-bromophenyl)-1-(3,4-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Cyclohexyl-5-oxo-N-(4-phenoxyphenyl)pyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
STK325139; 3-Pyrrolidinecarboxamide, 1-cyclohexyl-5-oxo-N-(4-phenoxyphenyl)-; CHEMBL217773; BDBM15666; CTK1H8990; DTXSID50387858; Pyrrolidine Carboxamide Compound s19; AKOS000340345; AKOS022076317; MCULE-9582565176; SR-01000251594; SR-01000251594-1
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-Chloro-2-methylphenyl)-1-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_073381; Oprea1_385024; CHEMBL217808; BDBM15699; Pyrrolidine Carboxamide Compound 3e; ZINC00827198; AKOS000340601; AKOS024302597; MCULE-6834325645; ST50004730; N-(3-chloro-2-methyl-phenyl)-1-(3-nitrophenyl)-5-oxo-pyrrolidine-3-carboxamide; N-(3-chloro-2-methylphenyl)-1-(3-nitrophenyl)-5-oxo-3-pyrrolidinecarboxamide; N-(3-chloro-2-methylphenyl)[1-(3-nitrophenyl)-5-oxopyrrolidin-3-yl]carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(4-Bromophenyl)-N-(3-chloro-2-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
ZINC00851730; Oprea1_434343; Oprea1_447282; CHEMBL274325; BDBM15700; Pyrrolidine Carboxamide Compound 3f; STK168673; ZINC00851729; AKOS000340713; AKOS022084242; MCULE-1503632545; SR-01000507580; SR-01000507580-1; 1-(4-bromophenyl)-N-(3-chloro-2-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-(Tert-butyl)phenyl 4-(3-(trifluoromethyl)phenyl)piperazinyl ketone
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Investigative | Compound Info | ||
| Synonyms |
4-(tert-butyl)phenyl 4-[3-(trifluoromethyl)phenyl]piperazinyl ketone; piperazine, a11; CHEMBL239892; BDBM25782; CTK7F6961; KS-00003PK8; ZINC2380994; MFCD01567649; STK093980; AKOS003276711; MCULE-8385000826; MS-7917; ST50720710; 1-(4-tert-butylbenzoyl)-4-[3-(trifluoromethyl)phenyl]piperazine; (4-tert-butylphenyl){4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methanone; [4-(tert-butyl)phenyl]{4-[3-(trifluoromethyl)phenyl]piperazino}methanone; 1-[(4-tert-butylphenyl)carbonyl]-4-[3-(trifluoromethyl)phenyl]piperazine
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[4-(Acetylamino)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Cambridge id 6957090; Oprea1_526741; CHEMBL426150; BDBM15663; Pyrrolidine Carboxamide Compound s16; STK168225; AKOS000342895; AKOS016521439; MCULE-1326292549; ST058687; SR-01000529824; SR-01000529824-1; 1-cyclohexyl-N-(4-acetamidophenyl)-5-oxopyrrolidine-3-carboxamide; N-(4-acetamidophenyl)-1-cyclohexyl-5-oxo-pyrrolidine-3-carboxamide; N-[4-(acetylamino)phenyl]-1-cyclohexyl-5-oxo-3-pyrrolidinecarboxamide; N-{4-[(1-cyclohexyl-5-oxopyrrolidin-3-yl)carbonylamino]phenyl}acetamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-Pyrazol-1-yl-N-[1-(4-pyridylmethyl)-4-piperidyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3335466; BDBM50026744
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-Chloro-2-methylphenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CBMicro_035460; Cambridge id 5852561; Oprea1_082917; Oprea1_595617; CHEMBL385297; BDBM15698; Pyrrolidine Carboxamide Compound 3d; STK168299; AKOS000340067; AKOS016164092; MCULE-2461947470; BIM-0035347.P001; AB00099325-01; N-(3-chloro-2-methyl-phenyl)-5-oxo-1-phenyl-pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(4-Tert-butylphenyl)-[4-(3-chloro-4-methylphenyl)piperazin-1-yl]methanone
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Investigative | Compound Info | ||
| Synonyms |
piperazine, a12; Oprea1_491687; Oprea1_758657; CHEMBL429275; BDBM25783; ZINC1114539; AKOS002291671; MCULE-8038472315; ST50779378; Z1736144769; 1-(4-tert-butylbenzoyl)-4-(3-chloro-4-methylphenyl)piperazine; 4-(tert-butyl)phenyl 4-(3-chloro-4-methylphenyl)piperazinyl ketone; 1-[(4-tert-butylphenyl)carbonyl]-4-(3-chloro-4-methylphenyl)piperazine
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-Chloro-2-methylphenyl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CBMicro_002702; Oprea1_064355; Oprea1_168037; CHEMBL215014; BDBM15701; Pyrrolidine Carboxamide Compound 3g; SMSF0017002; STK168666; AKOS000340425; AKOS016758109; CB04655; MCULE-8908347752; ST073121; BIM-0002804.P001; SR-01000510998; SR-01000510998-1; N-(3-chloro-2-methyl-phenyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(3-Chlorophenyl)-4-(4-isopropylbenzoyl)piperazine
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Investigative | Compound Info | ||
| Synonyms |
piperazine, a9; Oprea1_190633; CHEMBL394432; BDBM25780; ZINC476325; STK433059; AKOS003283680; MCULE-3441249598; ST50923480; AK-968/12973434; 4-(3-chlorophenyl)piperazinyl 4-(methylethyl)phenyl ketone; [4-(3-chlorophenyl)piperazin-1-yl][4-(propan-2-yl)phenyl]methanone; 1-(3-chlorophenyl)-4-{[4-(propan-2-yl)phenyl]carbonyl}piperazine
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-Chlorophenyl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CBMicro_043248; Oprea1_329776; Oprea1_680501; CHEMBL217885; BDBM15696; Pyrrolidine Carboxamide Compound 3b; STK000567; AKOS000340615; AKOS016758107; MCULE-9302505853; BIM-0043327.P001; ST50005699; Z28139975; N-(3-chlorophenyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide; N-(3-chlorophenyl)[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Cyclohexyl-N-(4-ethoxyphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Cambridge id 7111692; Oprea1_539661; CHEMBL217273; BDBM15665; Pyrrolidine Carboxamide Compound s18; STK168875; AKOS000340344; AKOS016521500; MCULE-6273795344; ST059478; SR-01000500566; SR-01000500566-1; 1-cyclohexyl-N-(4-ethoxyphenyl)-5-oxo-3-pyrrolidinecarboxamide; (1-cyclohexyl-5-oxopyrrolidin-3-yl)-N-(4-ethoxyphenyl)carboxamide; 1-cyclohexyl-N-(4-ethoxyphenyl)-5-oxo-pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-Chloro-2-methylphenyl)-5-oxo-1-[4-(propan-2-yloxy)phenyl]pyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217375; BDBM15702; Pyrrolidine Carboxamide Compound 3h; STK168702; AKOS000340179; AKOS022084248; MCULE-2439121156; N-(3-chloro-2-methyl-phenyl)-1-(4-isopropoxyphenyl)-5-oxo-pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Cyclohexyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213720; BDBM15684; Pyrrolidine Carboxamide Compound d18; STK218174; AKOS003345725; MCULE-5536806196; ST059225
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
CID 118714489
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3335464; BDBM50026743; N-(2-methoxyethyl)-N-[1-[(7-methyl-2-phenyl-1H-indol-3-yl)methyl]pyrrolidin-3-yl]methanesulfonamide
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-Cyclohexyl-N-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CBMicro_043533; Cambridge id 6065196; Oprea1_270510; Oprea1_308483; CHEMBL217274; BDBM15671; Pyrrolidine Carboxamide Compound d5; STK012478; AKOS000340121; AKOS016517389; MCULE-8305191084; ST066622; BIM-0043575.P001; 1-cyclohexyl-N-(2,6-dimethylphenyl)-5-oxo-3-pyrrolidinecarboxamide; 1-cyclohexyl-N-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxamide; 3-Pyrrolidinecarboxamide, 1-cyclohexyl-N-(2,6-dimethylphenyl)-5-oxo-; N-(2,6-dimethylphenyl)(1-cyclohexyl-5-oxopyrrolidin-3-yl)carboxamide
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
N-(3-Bromophenyl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_551225; Oprea1_703396; CHEMBL216063; BDBM15705; Pyrrolidine Carboxamide Compound 3k; STK396964; AKOS000612360; AKOS016338030; MCULE-2345942696; SR-01000508001; SR-01000508001-1; N-(3-bromophenyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide; N~3~-(3-bromophenyl)-1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxamide
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
N-(3-Chlorophenyl)-5-oxo-1-(4-propoxyphenyl)pyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415226; BDBM15697; Pyrrolidine Carboxamide Compound 3c; MCULE-6899883154
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-Pyrrolidinecarboxamide, N-(2-bromophenyl)-1-cyclohexyl-5-oxo-
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Investigative | Compound Info | ||
| Synonyms |
N-(2-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide; CHEMBL216547; BDBM15650; CTK2I1878; DTXSID80388095; Pyrrolidine Carboxamide Compound s3; STK218170; AKOS003345906; AKOS022076318; MCULE-4890832484; ST50666476; N-(2-bromophenyl)-1-cyclohexyl-5-oxo-3-pyrrolidinecarboxamide; N-(2-bromophenyl)-1-cyclohexyl-5-oxo-pyrrolidine-3-carboxamide; N-(2-bromophenyl)(1-cyclohexyl-5-oxopyrrolidin-3-yl)carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Chlorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_208478; Oprea1_820670; CHEMBL265016; BDBM15654; Pyrrolidine Carboxamide Compound s7; STK216374; AKOS003351221; MCULE-7748089198; ST059217; SR-01000304146; SR-01000304146-1; N-(4-chlorophenyl)-1-cyclohexyl-5-oxo-3-pyrrolidinecarboxamide; 3-Pyrrolidinecarboxamide, N-(4-chlorophenyl)-1-cyclohexyl-5-oxo-; N-(4-chlorophenyl)(1-cyclohexyl-5-oxopyrrolidin-3-yl)carboxamide; N-(4-chlorophenyl)-1-cyclohexyl-5-oxo-pyrrolidine-3-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[2-(4-Hexyl-2-hydroxyphenoxy)phenyl]-1,2-oxazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL428967; BDBM50373342
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| Activity |
IC50 = 311171.63 nM
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[9] | |||
| Compound Name |
2-[4-(4-Hexyl-2-hydroxyphenoxy)anilino]-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL262343; BDBM50373352
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| Activity |
IC50 = 518800.04 nM
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[9] | |||
| Compound Name |
5-Hexyl-2-[2-[(4-methylpiperazin-1-yl)methyl]phenoxy]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL408149; BDBM50373351
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| Activity |
IC50 = 762079.01 nM
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[9] | |||
| Compound Name |
N-[3-(4-Hexyl-2-hydroxyphenoxy)phenyl]-1,2-oxazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL405653; BDBM50373341
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| Activity |
IC50 = 820351.54 nM
|
[9] | |||
| Compound Name |
5-Hexyl-2-[4-[(4-methylpiperazin-1-yl)methyl]phenoxy]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL261355; BDBM50373339
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| Activity |
IC50 = 3273406.95 nM
|
[9] | |||
| Compound Name |
N-[4-(4-Hexyl-2-hydroxyphenoxy)phenyl]-1,2-oxazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260399; BDBM50373340
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| Activity |
IC50 = 7709034.69 nM
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[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies. Eur J Med Chem. 2015 Jan 27;90:436-47. | ||||
| REF 2 | Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system. J Med Chem. 2014 Aug 14;57(15):6572-82. | ||||
| REF 3 | Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. | ||||
| REF 4 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem. 2006 Oct 19;49(21):6308-23. | ||||
| REF 5 | Synthesis and antimycobacterial activity of 2,1'-dihydropyridomycins. ACS Med Chem Lett. 2012 Dec 18;4(2):264-8. | ||||
| REF 6 | Agonodepsides a and B: two new depsides from a filamentous fungus F7524. J Nat Prod. 2002 Jul;65(7):1037-8. | ||||
| REF 7 | Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem. 2007 Nov 1;15(21):6649-58. | ||||
| REF 8 | 2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis. ACS Med Chem Lett. 2014 Jul 11;5(9):1005-9. | ||||
| REF 9 | QSAR analysis of B-ring-modified diaryl ether derivatives as a InhA inhibitors. Med Chem Res. 2010 Dec 03;21:145-51. | ||||
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