Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78326 | Target Info | |||
| Target Name | N-acylethanolamine-hydrolyzing acidamidase (NAAA) | ||||
| Synonyms |
Nacylsphingosine amidohydrolaselike; Nacylethanolaminehydrolyzing acid amidase subunit beta; NAAA; Acid ceramidaselike protein; ASAHlike protein
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| Target Type | Literature-reported Target | ||||
| Gene Name | NAAA | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Cyclohexylbutyl N-[(2R,3S)-2-methyl-4-oxoazetidin-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770388; SCHEMBL17556816; 4-cyclohexylbutyl-N-[(2R,3S)-2-methyl-4-oxo-azetidin-3-yl]-carbamate
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-[(2-methylpropan-2-yl)oxy]-4-oxoazetidin-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061422; BDBM50234756
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-Cyclohexylbutyl N-[(2R,3S)-1-methoxy-2-methyl-4-oxoazetidin-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062812; BDBM50234750
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-Cyclohexylbutyl N-[(3S)-1-acetyl-2-oxoazetidin-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093224; BDBM50234747
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-Hydroxy-N-pentadecyl-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423904; N-Pentadecyl-3-hydroxypropanamide; BDBM50171286; ZINC44202137; N-(3-hydroxy-propionyl)pentadecanamide; J3.603.367C
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| Activity |
IC50 = 54000 nM
|
[3] | |||
| Compound Name |
Hexadecyl propionate
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Investigative | Compound Info | ||
| Synonyms |
hexadecyl propanoate; HEXADECYLPROPIONATE; 1-Hexadecanol, propanoate; Propionic acid hexadecyl ester; CHEMBL138543; Propanoic acid, hexadecyl ester; EINECS 228-301-4; Propionsaurecetylester; AI3-06111; SCHEMBL160710; CTK5B4778; DTXSID80211273; NSC53827; NSC67972; BDBM50171294; NSC-53827; NSC-67972; ZINC43382038; KS-000002L2; AS-57261
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| Activity |
IC50 = 54000 nM
|
[4] | |||
| Compound Name |
(Alphas)-N-Pentadecyl-alpha-hydroxybenzeneacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883768; BDBM50209839; J3.603.371A
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| Activity |
IC50 = 78000 nM
|
[5] | |||
| Compound Name |
N-Pentadecylisonicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884680; BDBM50209838
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| Activity |
IC50 = 98000 nM
|
[5] | |||
| Compound Name |
N-Pentadecylnaphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884760; BDBM50209841
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(Z)-N-(2-Hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398546; BDBM50063527
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]-N-(3-hydroxypropyl)hept-5-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398550; BDBM50063532
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]-N-[(2S)-1-hydroxypropan-2-yl]hept-5-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398549; BDBM50063531
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(Z)-N-(2-Hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-(4-iodophenyl)pent-1-enyl]-5-oxocyclopentyl]hept-5-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398547; BDBM50063530
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]-N-[(2R)-1-hydroxypropan-2-yl]hept-5-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398548; BDBM50063529
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(Z)-N-(2-Hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398545; BDBM50063528
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent alpha-amino--lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. Eur J Med Chem. 2016 Mar 23;111:138-59. | ||||
| REF 2 | Progress in the development of -lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives. Eur J Med Chem. 2017 Jan 27;126:561-575. | ||||
| REF 3 | The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem. 2005 Aug 11;48(16):5059-87. | ||||
| REF 4 | Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1210-3. | ||||
| REF 5 | Development of new inhibitors for N-acylethanolamine-hydrolyzing acid amidase as promising tool against bladder cancer. Bioorg Med Chem. 2017 Feb 1;25(3):1242-1249. | ||||
| REF 6 | Novel tail and head group prostamide probes. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1228-31. | ||||
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