Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78244 | Target Info | |||
| Target Name | Vasoactive intestinal polypeptide receptor (VIPR) | ||||
| Synonyms |
VIP-R; VIP receptor
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| Target Type | Discontinued Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R,4S)-2-Benzyl-5-[(4-butan-2-ylphenyl)sulfonylamino]-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924495; SCHEMBL17038273
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| Activity | Vasoactive intestinal polypeptide receptor 2 |
IC50 = 152000 nM
|
[1] | ||
| Compound Name |
(2R,4S)-2-Benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-[[4-(trifluoromethoxy)phenyl]sulfonylamino]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926854; SCHEMBL17038265
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| Activity | Vasoactive intestinal polypeptide receptor 2 |
IC50 = 152000 nM
|
[1] | ||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4285866
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|
Investigative | Compound Info | ||
| Activity | Vasoactive intestinal polypeptide receptor 1 |
EC50 = 298000 nM
|
[2] | ||
| Compound Name |
Chembl4280273
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|
Investigative | Compound Info | ||
| Activity | Vasoactive intestinal polypeptide receptor 1 |
EC50 = 619000 nM
|
[2] | ||
| Compound Name |
(2S,4S)-2-Benzyl-N-butyl-4-hydroxy-5-[(4-nitrophenyl)sulfonylamino]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971282; SCHEMBL17038221
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| Activity | Vasoactive intestinal polypeptide receptor 2 |
IC50 = 1800000 nM
|
[1] | ||
| Compound Name |
Chembl4295255
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|
Investigative | Compound Info | ||
| Activity | Vasoactive intestinal polypeptide receptor 2 |
EC50 = 8262000 nM
|
[2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | WO patent application no. 2014075093A1, INHIBITORS OF CENTRAL NERVOUS SYSTEM VASOACTIVE INHIBITORY PEPTIDE RECEPTOR 2 | ||||
| REF 2 | US patent application no. 20160045572A1, PEPTIDES COMPRISING NON-NATURAL AMINO ACIDS AND METHODS OF MAKING AND USING THE SAME | ||||
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