Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77393 | Target Info | |||
| Target Name | WD repeat-containing protein 5 (WDR5) | ||||
| Synonyms |
BMP2-induced 3-kb gene protein; BIG3
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| Target Type | Literature-reported Target | ||||
| Gene Name | WDR5 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
H2N-Ara-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085606; BDBM50318536
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Ac-AR-(N-Me)A-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1084620; BDBM50318538
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(4-Methoxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1625120; Enamine_000177; SCHEMBL9199162; HMS1394I01; ZINC493005; BDBM50465596; STK532678; AKOS005464967; MCULE-3441260298; 2-(4-methoxyphenyl)-5H,6H,7H-pyrrolo[1,2-a]imidazole; 2-(4-methoxyphenyl)-6,7-dihydro [5H]-pyrrolo[1,2-a]imidazole; 2-(4-Methoxyphenyl)-6,7-dihydro-[5H]-pyrrolo [1,2-a]imidazole; 2-(4-Methoxyphenyl)-6,7-dihydro-[5H]-pyrrolo[1,2 -a]imidazole; 2-(4-methoxyphenyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a] imidazole; 2-(4-methoxyphenyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a]imidazole
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| Activity |
Ki = 61000 nM
|
[2] | |||
| Compound Name |
Chembl4289013
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465566
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| Activity |
Ki = 64000 nM
|
[2] | |||
| Compound Name |
Chembl4284526
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465564
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| Activity |
Ki = 64300 nM
|
[2] | |||
| Compound Name |
H2N-ARTK(Me)QTARKS-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1082284; BDBM50318528
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| Activity |
IC50 = 69000 nM
|
[1] | |||
| Compound Name |
H2N-Artkqtarks-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1082281; BDBM50318524
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
H2N-ARTK(Me3)QTARKS-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1082286; BDBM50318530
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|
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| Activity |
IC50 = 73000 nM
|
[1] | |||
| Compound Name |
Chembl4281112
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Investigative | Compound Info | ||
| Synonyms |
6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methylindoline; BDBM50465597; 5-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methyl-2,3-dihydro-1H-indole
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| Activity |
Ki = 85200 nM
|
[2] | |||
| Compound Name |
Chembl4280671
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465588
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| Activity |
Ki = 109000 nM
|
[2] | |||
| Compound Name |
Chembl4291321
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465567
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| Activity |
Ki = 117000 nM
|
[2] | |||
| Compound Name |
Chembl4284833
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465553
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| Activity |
Ki = 118000 nM
|
[2] | |||
| Compound Name |
Chembl4287916
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465568
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| Activity |
Ki ~ 125000 nM
|
[2] | |||
| Compound Name |
Chembl4279456
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465589
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| Activity |
Ki ~ 125000 nM
|
[2] | |||
| Compound Name |
Ac-AR-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085605; BDBM50318549; ZINC49047585
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| Activity |
IC50 = 125000 nM
|
[1] | |||
| Compound Name |
H2N-Art-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085864; BDBM50318526
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|
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| Activity |
IC50 = 127000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1380070; SMR000146180; ChemDiv2_000115; MLS000552665; SCHEMBL989261; 5H-Pyrrolo[1,2-a]imidazole, 6,7-dihydro-2-phenyl-; HMS1369F05; HMS2284N05; ZINC241083; BDBM50465560; STL304711; AKOS003617684; CCG-103836; MCULE-4048005688; EU-0067344; 2-PHENYL-5H,6H,7H-PYRROLO[1,2-A]IMIDAZOLE
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|
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| Activity |
Ki = 323000 nM
|
[2] | |||
| Compound Name |
2-(4-Methylphenoxy)acetamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4282498; SCHEMBL9194768; 2-(4-methylphenoxy)ethanimidamide; BDBM50465561; ZINC16648157; AKOS000194417; MCULE-8064545670
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| Activity |
Ki = 589000 nM
|
[2] | |||
| Compound Name |
2-(3-Chlorophenoxy)ethanimidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4293101; Ethanimidamide,2-(3-chlorophenoxy)-; (3-Chlorophenoxy)ethanimidamide; SCHEMBL7782156; 2-(3-Chlorophenoxy)acetamidine; CTK4D3691; 2-(3-chlorophenoxy)acetimidamide; DTXSID30574204; BDBM50465587; MFCD09055319; ZINC16625746; AKOS000182098; MCULE-8347879586; DB-011941; FT-0731477; Y-5142
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| Activity |
Ki = 651000 nM
|
[2] | |||
| Compound Name |
[1,1'-Biphenyl]-4-carboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
BIPHENYL-4-CARBOXAMIDINE; 4-phenylbenzenecarboximidamide; CHEMBL4285882; 4-phenylbenzene-1-carboximidamide; Benzenylphenylamidin; 4-Phenylbenzamidine; ACMC-1C47E; SCHEMBL4021876; CTK0H4032; DTXSID20391301; ZINC1437952; 3861AJ; BDBM50465595; MFCD05662850; AKOS009311892; MCULE-5842249880; NE63962; SB32294; SC-40713; DB-062412; FT-0737364
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| Activity |
Ki = 843000 nM
|
[2] | |||
| Compound Name |
4-(2,3-Dihydro-imidazo[2,1-b]thiazol-6-yl)-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1502560; SMR000125083; Enamine_001433; Oprea1_068935; Oprea1_773195; MLS000067686; ZINC81023; 4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)phenol; HMS1398B03; HMS2170D23; HMS3353I21; BDBM50465562; NSC732196; STK723342; AKOS000623711; MCULE-1376019138; NSC-732196; ST081844; 4-(2H,3H-imidazo[2,1-b]1,3-thiazolidin-6-yl)phenol; 4-{2H,3H-IMIDAZO[2,1-B][1,3]THIAZOL-6-YL}PHENOL
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| Activity |
Ki > 1000000 nM
|
[2] | |||
| Compound Name |
2-(4-Ethoxyphenyl)imidazo[1,2-a]pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1602085; 2-(4-Ethoxy-phenyl)-imidazo[1,2-a]pyridine; Oprea1_121236; Oprea1_365163; MLS000689049; SCHEMBL13325732; HMS2713A03; ZINC122026; BBL020214; BDBM50465563; CCG-19769; MFCD00197518; STK830480; AKOS000547557; MCULE-6154439202; SMR000283173; K-5912; AB00100816-01; Z56754395
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|
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| Activity |
Ki > 1000000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. J Med Chem. 2010 Jul 22;53(14):5179-85. | ||||
| REF 2 | Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J Med Chem. 2018 Jul 12;61(13):5623-5642. | ||||
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