Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77350 | Target Info | |||
| Target Name | Proteasome beta-8 (PS beta-8) | ||||
| Synonyms |
Y2; Really interesting new gene 10 protein; RING10; Proteasome subunit beta-5i; Proteasome subunit beta type-8; Proteasome component C13; PSMB5i; Multicatalytic endopeptidase complex subunit C13; Macropain subunit C13; Low molecular mass protein 7; LMP7
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| Target Type | Clinical trial Target | ||||
| Gene Name | PSMB8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-N-[(2S)-3-(1-Adamantyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319477; BDBM50099658
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Chembl4128074
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274034
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Chembl4127967
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274041
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Chembl4129702
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273999
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| Activity |
IC50 = 136500 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based design of 1i or 5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209. | ||||
| REF 2 | Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides. J Med Chem. 2018 Jun 28;61(12):5395-5411. | ||||
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