Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77181 | Target Info | |||
| Target Name | Ubiquitin thioesterase L3 (UCHL3) | ||||
| Synonyms |
Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | UCHL3 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Menadione
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
menadione; 58-27-5; Vitamin K3; 2-Methyl-1,4-naphthoquinone; Menaphthone; 2-methylnaphthalene-1,4-dione; 2-Methylnaphthoquinone; Thyloquinone; Panosine; Klottone; Kayquinone; Kappaxin; Kayklot; Kolklot; 2-Methyl-1,4-naphthalenedione; Menaphthon; Menadion; Kipca; Kanone; Mitenone; Kativ-G; Kaergona; Aquinone; Prokayvit; Mitenon; Koaxin; Kaykot; Kareon; Hemodal; Aquakay; Synkay; Karcon; K-Thrombyl; K-Vitan; Kipca-Oil Soluble; Juva-K; Vitamin K2(0); Vitamin K0; Menaquinone 0; Vitamin K 3; Menaphtone; Menadionum; 2-Methyl-1,4-naphthochinon; Usaf; Aquakay; Klottone;Koaxin; Memodol; Methylnaphthoquinone; Vicasol; Menadione semiquinone; M0373; VK3; Kappaxan (VAN); Kappaxin (TN); Kipca, oil soluble; Menadione (K3); Menadione (USP); Menadione [USAN:BAN]; Usaf ek-5185; Vitamin-K3; Methyl-1,4-naphthalenedione; Methyl-1,4-naphthoquinone; Vitamin K3 : 2-Methyl-1,4-naphthoquinone; 1,4-Naphthalenedione, 2-methyl-,radical ion(1-); 2-Methyl-1,4-naftochinon; 2-Methyl-1,4-naftochinon [Czech]; 2-Methyl-1,4-naphthochinon [German]; 2-methyl-1,4-naphthoquinone, 5; 3-Methyl-1,4-naphthoquinone; Ascorbic acid/menadione; Triglycyl-lysine-vasopressin
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[1] | |||
| Compound Name |
LDN-91946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 7
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
1-Benzyl-3-hydroxy-4-(5-methyl-2-furoyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000072982; MLS000062361; MLS002541686; CHEMBL392515; HMS2441G05; STK817365; AKOS000527541; AKOS016059778; MCULE-2236832028; ST50097039
Click to Show/Hide
|
||||
| Activity |
IC50 = 103000 nM
|
[2] | |||
| Compound Name |
(4E)-5-(4-Fluorophenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
R140309; Oprea1_165422; CHEMBL391878; SCHEMBL20007526; STK702569; STK854993; AKOS000528139; AKOS005631273; AKOS016290984; MCULE-7189315442; AB00118738-01; SR-01000487384; SR-01000487384-1; Z56864021
Click to Show/Hide
|
||||
| Activity |
IC50 = 123000 nM
|
[2] | |||
| Compound Name |
3-Hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000107617; CBMicro_002545; Cambridge id 6237842; Oprea1_183242; MLS000111695; MLS002540460; CHEMBL391877; HMS2394F11; SMSF0018305; STK866353; AKOS000569043; AKOS002558721; AKOS016318112; CB04120; CCG-107091; MCULE-2915677534; BIM-0002440.P001; AB00439791-05; SR-01000438248; SR-01000438248-1; Z57087794; F1065-0075
Click to Show/Hide
|
||||
| Activity |
IC50 = 154000 nM
|
[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4129140
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3709928; BDBM50271098; 3-acetyl-2-(4-bromophenyl)-1-[2-(3,4-dichlorophenyl)ethyl]-4-hydroxy-2H-pyrrol-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol. 2007 Nov;3(11):697-705. | ||||
| REF 2 | Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg Med Chem. 2007 Nov 1;15(21):6810-8. | ||||
| REF 3 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2018 Jan 25;61(2):422-443. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.