Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76910 | Target Info | |||
| Target Name | Glycogen synthase kinase-3 alpha (GSK-3A) | ||||
| Synonyms |
Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
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| Target Type | Successful Target | ||||
| Gene Name | GSK3A | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 45 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
I-5
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|
Investigative | Compound Info | ||
| Synonyms |
SB-409513; 2-CHLORO-5-[4-(3-CHLORO-PHENYL)-2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-3-YLAMINO]-BENZOIC ACID; I-5; 2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid; AC1L9LHU; 4-arylmaleimide deriv. 6-z; CHEMBL156987; BDBM8269; SCHEMBL10059345; HMS3303B04; HMS3305M22; DB01793; NCGC00241937-01; AB01092116-01; 2-(3-Carboxy-4-chlorophenylamino)-3-(3-chlorophenyl)maleimide; 2-chloro-5-[[4-(3-chlorophenyl)-2,5-dioxopyrrol-3-yl]amino]benzoic acid
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| Activity |
IC50 = 76000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-i
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158885; BDBM8252; BDBM50373088; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(2-nitrophenyl)maleimide; 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-j
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Investigative | Compound Info | ||
| Synonyms |
BDBM8253; CHEMBL422714; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(3-chlorophenyl)maleimide; 3-(3-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-d
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL345348; BDBM8247; BDBM50373081; 2-(3-Chloro-4-hydroxyphenylamino)-3-(3-nitrophenyl)maleimide; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 59000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6l
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL345801; BDBM8229; BDBM50373084; 2-(3-Chlorophenylamino)-3-(3-nitrophenyl)maleimide; 3-[(3-chlorophenyl)amino]-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-o
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL347681; BDBM8258; BDBM50373077; 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 71000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-x
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Investigative | Compound Info | ||
| Synonyms |
BDBM8267; CHEMBL345212; 2-(3-Carboxy-4-chlorophenylamino)-3-(2-chlorophenyl)maleimide; 2-chloro-5-{[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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| Activity |
IC50 = 74000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-t
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL159149; BDBM8263; BDBM50373080; 2-(3-Carboxyphenylamino)-3-(3-nitrophenyl)maleimide; 3-{[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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|
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| Activity |
IC50 = 79000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-h
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Investigative | Compound Info | ||
| Synonyms |
BDBM8251; CHEMBL345800; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(2-methoxyphenyl)maleimide; 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 82000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-n
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Investigative | Compound Info | ||
| Synonyms |
BDBM8257; CHEMBL346721; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(4-methoxyphenyl)maleimide; 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 83000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6aa
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Investigative | Compound Info | ||
| Synonyms |
BDBM8270; CHEMBL349810; 2-(3-Carboxy-4-chlorophenylamino)-3-(3-methoxyphenyl)maleimide; 2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-m
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8256; CHEMBL347134; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 91000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-g
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Investigative | Compound Info | ||
| Synonyms |
SB-390523; BDBM8250; CHEMBL157258; HMS3303N04; HMS3305A17; NCGC00241949-01; AB01092114-01; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(2-chlorophenyl)maleimide; 3-(2-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 93000 nM
|
[1] | |||
| Compound Name |
3-[(3-Chloro-4-Hydroxyphenyl)amino]-4-(3-Chlorophenyl)-1h-Pyrrole-2,5-Dione
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Investigative | Compound Info | ||
| Synonyms |
SB-409514; 4-arylmaleimide deriv. 6-c; BDBM8246; CHEMBL160333; HMS3303K03; HMS3306K01; NCGC00241930-01; AB01092117-01; Q27453208; 2-(3-Chloro-4-hydroxyphenylamino)-3-(3-chlorophenyl)maleimide
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|
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| Activity |
IC50 = 94000 nM
|
[1] | |||
| Compound Name |
3,6-Diamino-2-(3-chlorobenzoyl)-4-(2-iodophenyl)thieno[2,3-b]pyridine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2313844; SCHEMBL1539816; BDBM50424225
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(4S,6E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668419; BDBM50336461
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Cyclapolin 9
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Investigative | Compound Info | ||
| Synonyms |
Cyclapolin-9; CHEMBL476124; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide; 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide; SCHEMBL5055142; CTK8I6133; AOB5979; ZINC2577648; BDBM50263697; AKOS024457436; HY-15159; CS-0003792; 7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide; 2-(aminocarbonyl)-7-nitro-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-3-olate
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3,6-Diamino-2-(3-chlorobenzoyl)-4-(2-chlorophenyl)thieno[2,3-b]pyridine-5-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2313853; SCHEMBL1539791; BDBM50424223
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3,6-Diamino-2-(4-chlorobenzoyl)-4-(2-iodophenyl)thieno[2,3-b]pyridine-5-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2313821; Oprea1_107850; Oprea1_804702; SCHEMBL1539850; BDBM50424221; STK725766; ZINC33355350; AKOS005524273; MCULE-7383740589; EU-0051729; AE-848/31937053; SR-01000519087; SR-01000519087-1
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide
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Investigative | Compound Info | ||
| Synonyms |
Cyclapolin 1; 2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-3-oxide; SCHEMBL5062617; CHEMBL1222044; CTK2H1083; DTXSID10429521; 7-nitro-3-oxido-5-(trifluoromethylsulfanyl)-1,3-benzothiazol-3-ium-2-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3,6-Diamino-2-benzoyl-4-(2-methoxyphenyl)thieno[2,3-b]pyridine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314102; SCHEMBL1539786; BDBM50424226
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(4S,6E,12E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668418; BDBM50336459
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3,6-Diamino-4-(2-bromophenyl)-2-(3-chlorobenzoyl)thieno[2,3-b]pyridine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2313850; SCHEMBL1539807; BDBM50424224
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Arylmaleimide deriv. 6j
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346066; BDBM8227; BDBM50373089; 2-(3-Chlorophenylamino)-3-(2-nitrophenyl)maleimide; 3-[(3-chlorophenyl)amino]-4-(2-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 104000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6cc
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|
Investigative | Compound Info | ||
| Synonyms |
SB-360741; BDBM8272; CHEMBL160876; HMS3303D02; HMS3305J07; NCGC00241908-01; AB01092111-01; 2-(3-Carboxy-4-chlorophenylamino)-3-(4-chlorophenyl)maleimide; 2-chloro-5-{[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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|
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| Activity |
IC50 = 109000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6ff
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8275; CHEMBL349540; 2-[4-(Methylthio)phenylamino]-3-(2-methoxyphenyl)maleimide; 3-(2-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 110000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6i
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8226; CHEMBL156277; 2-(3-Chlorophenylamino)-3-(2-methoxyphenyl)maleimide; 3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 114000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6x
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155680; BDBM8241; BDBM50373082; 2-(4-Hydroxyphenylamino)-3-(3-nitrophenyl)maleimide; 3-[(4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 123000 nM
|
[1] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824332; BDBM50352494
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|
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| Activity |
IC50 = 130000 nM
|
[5] | |||
| Compound Name |
4-Arylmaleimide deriv. 8c
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158719; BDBM8288; SCHEMBL6586836; BDBM50373074; 2-(Indoline-1-yl)-3-(2-nitrophenyl)maleimide; 3-(2,3-dihydro-1H-indol-1-yl)-4-(2-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 131000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-r
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8261; CHEMBL345364; 2-(3-Carboxyphenylamino)-3-(3-chlorophenyl)maleimide; 3-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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|
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| Activity |
IC50 = 134000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-q
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8260; CHEMBL350702; 2-(3-Carboxyphenylamino)-3-(2-chlorophenyl)maleimide; 3-{[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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|
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| Activity |
IC50 = 136000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-a
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8244; CHEMBL157089; 2-(3-Chloro-4-hydroxyphenylamino)-3-(2-methoxyphenyl)maleimide; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 139000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6d
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL346371; BDBM8221; BDBM50373085; 2-(Phenylamino)-3-(3-nitrophenyl)maleimide; 3-(3-nitrophenyl)-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 141000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-k
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8254; CHEMBL157348; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-(3-methoxyphenyl)maleimide; 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 142000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-w
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8266; CHEMBL160251; 2-(3-Carboxy-4-chlorophenylamino)-3-phenylmaleimide; 2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid
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|
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| Activity |
IC50 = 143000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-f
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8249; CHEMBL347857; 2-(3,5-Dichloro-4-hydroxyphenylamino)-3-phenylmaleimide; 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 149000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6II
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346996; BDBM8278; BDBM50373078; 2-[4-(Methylthio)phenylamino]-3-(3-nitrophenyl)maleimide; 3-{[4-(methylsulfanyl)phenyl]amino}-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 152000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6z
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8243; CHEMBL157141; 2-(3-Chloro-4-hydroxyphenylamino)-3-(2-chlorophenyl)maleimide; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-chlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 152000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6ee
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8274; CHEMBL156563; 2-[4-(Methylthio)phenylamino]-3-(2-chlorophenyl)maleimide; 3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 161000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 8e
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156153; BDBM8290; BDBM50373073; 2-(Indoline-1-yl)-3-(3-nitrophenyl)maleimide; 3-(2,3-dihydro-1H-indol-1-yl)-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 161000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-e
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8248; CHEMBL156684; 2-(3-Chloro-4-hydroxyphenylamino)-3-(4-chlorophenyl)maleimide; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(4-chlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 173000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-u
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8264; CHEMBL347632; 2-(3-Carboxyphenylamino)-3-(4-chlorophenyl)maleimide; 3-{[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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|
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| Activity |
IC50 = 186000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6h
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8225; CHEMBL156506; 2-(3-Chlorophenylamino)-3-(2-chlorophenyl)maleimide; 3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
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|
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| Activity |
IC50 = 195000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-s
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8262; CHEMBL346493; 2-(3-Carboxyphenylamino)-3-(3-methoxyphenyl)maleimide; 3-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
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|
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| Activity |
IC50 = 195000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 37 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
SKF-62604; 4-arylmaleimide deriv. 6a; phenyl anilino-maleimide; AC1O6ZNQ; BDBM8218; SCHEMBL5682682; CHEMBL346551; HMS3303J01; HMS3305A03; 2-(Phenylamino)-3-phenylmaleimide; 3-anilino-4-phenylpyrrole-2,5-dione; NCGC00241898-01; AB01092118-01
Click to Show/Hide
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| Activity |
IC50 = 529000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6hh
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Investigative | Compound Info | ||
| Synonyms |
BDBM8277; CHEMBL158526; 2-[4-(Methylthio)phenylamino]-3-(3-methoxyphenyl)maleimide; 3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione
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||||
| Activity |
IC50 = 203000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-v
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Investigative | Compound Info | ||
| Synonyms |
BDBM8265; CHEMBL156218; 2-(3-Carboxyphenylamino)-3-(4-methoxyphenyl)maleimide; 3-{[4-(4-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 214000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6b
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Investigative | Compound Info | ||
| Synonyms |
BDBM8219; CHEMBL347647; 2-(Phenylamino)-3-(2-chlorophenyl)maleimide; 3-(2-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
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||||
| Activity |
IC50 = 216000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6c
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Investigative | Compound Info | ||
| Synonyms |
SB-376719; BDBM8220; CHEMBL156263; HMS3303A03; HMS3305K17; NCGC00241921-01; 2-(Phenylamino)-3-(2-methoxyphenyl)maleimide; AB01092113-01; 3-(2-methoxyphenyl)-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 216000 nM
|
[1] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824540; BDBM50352492
Click to Show/Hide
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||||
| Activity |
IC50 = 220000 nM
|
[5] | |||
| Compound Name |
4-Arylmaleimide deriv. 6u
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158559; BDBM8238; BDBM50373083; 2-(3-Hydroxyphenylamino)-3-(3-nitrophenyl)maleimide; 3-[(3-hydroxyphenyl)amino]-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 236000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6kk
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM8280; CHEMBL160598; 2-[4-(Methylthio)phenylamino]-3-(4-methoxyphenyl)maleimide; 3-(4-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 243000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6r
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL155931; BDBM8235; BDBM50373087; 2-(3-Hydroxyphenylamino)-3-(2-nitrophenyl)maleimide; 3-[(3-hydroxyphenyl)amino]-4-(2-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 251000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6k
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Investigative | Compound Info | ||
| Synonyms |
BDBM8228; CHEMBL346829; 2-(3-Chlorophenylamino)-3-(3-methoxyphenyl)maleimide; 3-[(3-chlorophenyl)amino]-4-(3-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 257000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6q
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Investigative | Compound Info | ||
| Synonyms |
BDBM8234; CHEMBL160231; 2-(3-Hydroxyphenylamino)-3-(2-methoxyphenyl)maleimide; 3-[(3-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 259000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6-p
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Investigative | Compound Info | ||
| Synonyms |
BDBM8259; CHEMBL348505; 2-(3-Carboxyphenylamino)-3-phenylmaleimide; 3-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 291000 nM
|
[1] | |||
| Compound Name |
3-(3-Chloroanilino)-4-phenylpyrrole-2,5-dione
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Investigative | Compound Info | ||
| Synonyms |
4-arylmaleimide deriv. 6g; BDBM8224; CHEMBL351356; SCHEMBL2835418; 2-(3-Chlorophenylamino)-3-phenylmaleimide; 3-(3-Chlorophenylamino)-4-phenylpyrrole-2,5-dione; 3-[(3-chlorophenyl)amino]-4-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 301000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6y
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM8242; CHEMBL156808; 2-(4-Hydroxyphenylamino)-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-[(4-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 317000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 8a
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM8286; CHEMBL155967; 2-(Indoline-1-yl)-3-(2-chlorophenyl)maleimide; 3-(2-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 337000 nM
|
[1] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824334; BDBM50352493
Click to Show/Hide
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||||
| Activity |
IC50 = 370000 nM
|
[5] | |||
| Compound Name |
4-Arylmaleimide deriv. 6p
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SB-390527; BDBM8233; CHEMBL160937; HMS3303F04; HMS3305O05; NCGC00241941-01; AB01092115-01; 2-(3-Hydroxyphenylamino)-3-(2-chlorophenyl)maleimide; 3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 374000 nM
|
[1] | |||
| Compound Name |
1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(phenylamino)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
4-arylmaleimide deriv. 6f; BDBM8223; CHEMBL156807; SCHEMBL7781089; CTK0I6155; DTXSID70424890; 2-(Phenylamino)-3-(4-methoxyphenyl)maleimide; 3-(4-methoxyphenyl)-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 390000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6ll
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158835; BDBM8281; BDBM50373076; 3-{[4-(methylsulfanyl)phenyl]amino}-4-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 392000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6dd
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Investigative | Compound Info | ||
| Synonyms |
BDBM8273; CHEMBL434484; 2-[4-(Methylthio)phenylamino]-3-phenylmaleimide; 3-{[4-(methylsulfanyl)phenyl]amino}-4-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 404000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6v
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Investigative | Compound Info | ||
| Synonyms |
BDBM8239; CHEMBL347419; 2-(3-Hydroxyphenylamino)-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 407000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6m
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Investigative | Compound Info | ||
| Synonyms |
BDBM8230; CHEMBL160938; 2-(3-Chlorophenylamino)-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 447000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 8d
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Investigative | Compound Info | ||
| Synonyms |
BDBM8289; CHEMBL346107; 2-(Indoline-1-yl)-3-(3-chlorophenyl)maleimide; 3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 460000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6t
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Investigative | Compound Info | ||
| Synonyms |
BDBM8237; CHEMBL160373; 2-(3-Hydroxyphenylamino)-3-(3-methoxyphenyl)maleimide; 3-[(3-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 472000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6w
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Investigative | Compound Info | ||
| Synonyms |
BDBM8240; CHEMBL160829; 2-(3-Hydroxyphenylamino)-3-(4-methoxyphenyl)maleimide; 3-[(3-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 481000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6e
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Investigative | Compound Info | ||
| Synonyms |
BDBM8222; CHEMBL160968; 2-(Phenylamino)-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 514000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6jj
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Investigative | Compound Info | ||
| Synonyms |
BDBM8279; CHEMBL351342; 2-[4-(Methylthio)phenylamino]-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 529000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6gg
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Investigative | Compound Info | ||
| Synonyms |
BDBM8276; CHEMBL160743; 2-[4-(Methylthio)phenylamino]-3-(3-chlorophenyl)maleimide; 3-(3-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 532000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 8g
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Investigative | Compound Info | ||
| Synonyms |
SB-361058; BDBM8292; CHEMBL347580; HMS3303L17; HMS3305C16; NCGC00242135-01; AB01092112-01; 2-(Indoline-1-yl)-3-(4-methoxyphenyl)maleimide; 3-(2,3-dihydro-1H-indol-1-yl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 694000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6o
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Investigative | Compound Info | ||
| Synonyms |
BDBM8232; CHEMBL350435; 2-(3-Hydroxyphenylamino)-3-phenylmaleimide; 3-[(3-hydroxyphenyl)amino]-4-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 704000 nM
|
[1] | |||
| Compound Name |
1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824539; BDBM50352491
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||||
| Activity |
IC50 = 1120000 nM
|
[5] | |||
| Compound Name |
4-Arylmaleimide deriv. 7c
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL156801; BDBM8284; BDBM50373075; 2-(Methylphenylamino)-3-(3-nitrophenyl)maleimide; 3-[methyl(phenyl)amino]-4-(3-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 1398000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 8f
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SB-333612; BDBM8291; CHEMBL156524; HMS3303P10; HMS3305F16; NCGC00242029-01; 2-(Indoline-1-yl)-3-(4-chlorophenyl)maleimide; AB01092109-01; 3-(4-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 1412000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 6s
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8236; CHEMBL351801; 2-(3-Hydroxyphenylamino)-3-(3-chlorophenyl)maleimide; 3-(3-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 1478000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 7d
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM8285; CHEMBL435045; 2-(Methylphenylamino)-3-(4-chlorophenyl)maleimide; 3-(4-chlorophenyl)-4-[methyl(phenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 2285000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 7a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8282; CHEMBL351334; 2-(Methylphenylamino)-3-phenylmaleimide; 3-[methyl(phenyl)amino]-4-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 2613000 nM
|
[1] | |||
| Compound Name |
4-Arylmaleimide deriv. 7b
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8283; CHEMBL155904; 2-(Methylphenylamino)-3-(3-methoxyphenyl)maleimide; 3-(3-methoxyphenyl)-4-[methyl(phenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 4500000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg Med Chem Lett. 2001 Mar 12;11(5):635-9. | ||||
| REF 2 | 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. J Med Chem. 2013 Jan 10;56(1):264-75. | ||||
| REF 3 | Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1167-70. | ||||
| REF 4 | Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. | ||||
| REF 5 | Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5610-5. | ||||
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