Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76846 | Target Info | |||
| Target Name | Melanocortin receptor 3 (MC3R) | ||||
| Synonyms |
MC3-R
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | MC3R | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 77 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MK-51
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|
Phase 1 | Compound Info | ||
| Synonyms |
MK-52; MK-52); Moderately potent glucocorticoid (topical (SILEC), skin disease), MIKA; Potent glucocorticoid (topical (SILEC), skin disease), MIKA
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|
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| Activity |
Ki = 68000 nM
|
[1] | |||
| Compound Name |
N-((1r,4r)-4-Aminocyclohexyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238367; BDBM50217641
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|
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| Activity |
Ki = 50000 nM
|
[2] | |||
| Compound Name |
N-(4-Guanidino-butyl)-3-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235802; SCHEMBL7866114; BDBM50217754; N-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
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| Activity |
Ki = 50000 nM
|
[2] | |||
| Compound Name |
N-Benzhydryl-N-{[carbamoylmethyl-((R)-1-phenyl-ethyl)-carbamoyl]-methyl}-2-(3-guanidino-propylamino)-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417853; BDBM50126393
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(5-Aminopentyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236842; BDBM50217792
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|
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| Activity |
Ki = 50000 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-N-[3-cyclohexyl-4-(1,2,4-triazol-1-yl)butyl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403722; BDBM50372552
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|
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(3-Amino-propyl)-3-[(1H-indol-3-ylmethyl)-amino]-2-[(naphthalen-2-ylmethyl)-amino]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269776; BDBM50111156; N-(3-Aminopropyl)-Nalpha-(2-naphthylmethyl)-3-[(1H-indole-3-ylmethyl)amino]-L-alaninamide
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|
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| Activity |
Ki = 50118.72 nM
|
[5] | |||
| Compound Name |
N-(2-Aminoethyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237719; BDBM50217725
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|
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| Activity |
Ki = 51000 nM
|
[2] | |||
| Compound Name |
N-(4-Hydroxy-2-methoxycinnamyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238345; BDBM50217681
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|
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| Activity |
Ki = 51000 nM
|
[2] | |||
| Compound Name |
N-(2,6-Difluorobenzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235359; BDBM50217653
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|
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| Activity |
Ki = 52000 nM
|
[2] | |||
| Compound Name |
N-(3-(4-(3-Aminopropyl)piperazin-1-yl)propyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398980; BDBM50217679
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|
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| Activity |
Ki = 52000 nM
|
[2] | |||
| Compound Name |
N-(1H-Indole-3-ylmethyl)-N-(1-naphthylmethyl)-L-argininamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113280; BDBM50451493
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|
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| Activity |
Ki = 52000 nM
|
[6] | |||
| Compound Name |
(R)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9138; MK-14; BDBM50111193; Nalpha-(2-Naphthylmethyl)-D-tryptophanamide
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|
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
N-(3-Guanidino-propyl)-3-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235798; SCHEMBL7866512; BDBM50217737; N-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
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| Activity |
Ki = 53000 nM
|
[2] | |||
| Compound Name |
2-[(1R,4S,7S,13S,16S,19R,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-14-methyl-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099889; BDBM50263842
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|
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| Activity |
Ki = 53703.18 nM
|
[7] | |||
| Compound Name |
N-(2-Fluorobenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394394; BDBM50217744
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|
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| Activity |
Ki = 55000 nM
|
[2] | |||
| Compound Name |
(2R,5R)-5-Acetamido-N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]-2-[(4-fluorophenyl)methyl]-6-phenylhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203252; BDBM50179461
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|
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| Activity |
Ki = 55474 nM
|
[8] | |||
| Compound Name |
(S)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9274; BDBM50111202; Nalpha-(2-Naphthylmethyl)-L-tryptophanamide
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|
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| Activity |
Ki = 56000 nM
|
[1] | |||
| Compound Name |
N-(2-Guanidino-ethyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238353; BDBM50217672; N-[2-(diaminomethylideneamino)ethyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
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| Activity |
Ki = 57000 nM
|
[2] | |||
| Compound Name |
1-(3-Aminocyclohexyl)-3-(3-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235162; BDBM50217685
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|
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| Activity |
Ki = 57000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-2-naphthalenemethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8201; BDBM50111154; N*1*-Naphthalen-2-ylmethyl-propane-1,3-diamine
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|
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| Activity |
Ki = 57000 nM
|
[6] | |||
| Compound Name |
N-(5-Aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393359; BDBM50217651
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|
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| Activity |
Ki = 58000 nM
|
[2] | |||
| Compound Name |
N-(2-Amino-ethyl)-2,3-bis-[(naphthalen-2-ylmethyl)-amino]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266305; BDBM50111165; N-(2-Aminoethyl)-Nalpha-(2-naphthylmethyl)-3-[(2-naphthylmethyl)amino]-L-alaninamide
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|
||||
| Activity |
Ki = 58000 nM
|
[6] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-(naphthalen-2-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8045; SCHEMBL7866517; ZINC2470883; BDBM50111160; CCG-21696; STK145901; AKOS001663451; MCULE-4974518103; NCGC00312134-01; EU-0046826; N-(2-Naphthylmethyl)-1H-indole-3-ethanamine; AB01159365-02; [2-(1H-indol-3-yl)ethyl](2-naphthylmethyl)amine; [2-(1H-Indol-3-yl)-ethyl]-naphthalen-2-ylmethyl-amine; Z323162460; [2-(1H-indol-3-yl)ethyl][(naphthalen-2-yl)methyl]amine
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|
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| Activity |
Ki = 59000 nM
|
[6] | |||
| Compound Name |
1-((1r,4r)-4-Aminocyclohexyl)-3-(3-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238369; BDBM50217636
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|
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| Activity |
Ki = 59000 nM
|
[2] | |||
| Compound Name |
N-(5-Aminopentyl)-4-(1H-indol-3-yl)-N-(3-phenylpropyl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393557; BDBM50217699
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|
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| Activity |
Ki = 61000 nM
|
[2] | |||
| Compound Name |
N-((1R,2R)-2-Aminocyclohexyl)-N-cinnamyl-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268395; BDBM50217701
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|
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| Activity |
Ki = 62000 nM
|
[2] | |||
| Compound Name |
(Z)-N-(4-((4-Aminocyclohexyl)methyl)cyclohexyl)-N-(2-chloro-3-phenylallyl)-2-(naphthalen-2-yloxy)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237702; BDBM50217634
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|
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| Activity |
Ki = 62000 nM
|
[2] | |||
| Compound Name |
(E)-N-(3-Aminopropyl)-N-(2-methyl-3-phenylallyl)-4-(thiophen-2-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394647; BDBM50217694
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|
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| Activity |
Ki = 63000 nM
|
[2] | |||
| Compound Name |
N-(4-Aminobutyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237687; BDBM50217767
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|
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| Activity |
Ki = 63000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237314; SCHEMBL7864860; BDBM50217643
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|
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| Activity |
Ki = 63000 nM
|
[2] | |||
| Compound Name |
(Z)-N-(4-((4-Amino-3-methylcyclohexyl)methyl)-2-methylcyclohexyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238153; BDBM50217671
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|
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| Activity |
Ki = 64000 nM
|
[2] | |||
| Compound Name |
N-(2-Carbamimidamidoethyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235147; BDBM50217751; N-[2-(diaminomethylideneamino)ethyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
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| Activity |
Ki = 65000 nM
|
[2] | |||
| Compound Name |
(Z)-N-(2-Aminoethyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428022; BDBM50217673
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|
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| Activity |
Ki = 65000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393918; BDBM50217661
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|
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| Activity |
Ki = 65000 nM
|
[2] | |||
| Compound Name |
N-(2,6-Difluorobenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394073; BDBM50217775
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|
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| Activity |
Ki = 65000 nM
|
[2] | |||
| Compound Name |
N-(4-Aminobutyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392096; BDBM50217689
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|
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| Activity |
Ki = 67000 nM
|
[2] | |||
| Compound Name |
N-(2-Aminoethyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236447; SCHEMBL7864880; BDBM50217747
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|
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| Activity |
Ki = 68000 nM
|
[2] | |||
| Compound Name |
N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-{2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl}-N-[(3-methylphenyl)methyl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394646; BDBM50217769
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|
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| Activity |
Ki = 78000 nM
|
[2] | |||
| Compound Name |
(Z)-N-(3-(4-(3-Aminopropyl)piperazin-1-yl)propyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398777; BDBM50217703
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|
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| Activity |
Ki = 78000 nM
|
[2] | |||
| Compound Name |
N-(2-Bromobenzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237714; BDBM50217741
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|
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| Activity |
Ki = 80000 nM
|
[2] | |||
| Compound Name |
N-(3-Guanidinopropyl)-1-(2-naphthylmethyl)-4alpha-hydroxy-L-prolinamide
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|
Investigative | Compound Info | ||
| Synonyms |
MK-70; CHEMBL1159700
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|
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| Activity |
Ki = 82000 nM
|
[1] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-(1H-indol-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269653; Cambridge id 5569632; SCHEMBL798249; ZINC2738721; BDBM50111161; STK090651; AKOS003260951; MCULE-6799391488; (2-indol-3-ylethyl)(indol-3-ylmethyl)amine; ST45146358; AB00089669-01; N-(1H-Indole-3-ylmethyl)-1H-indole-3-ethanamine; [2-(1H-Indol-3-yl)-ethyl]-(1H-indol-3-ylmethyl)-amine
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|
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| Activity |
Ki = 86000 nM
|
[6] | |||
| Compound Name |
N-(2-Bromo-4,5-dimethoxycinnamyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236002; BDBM50217735
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|
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| Activity |
Ki = 94000 nM
|
[2] | |||
| Compound Name |
1-((1r,4R)-4-Aminocyclohexyl)-3-((1r,4R)-4-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429269; BDBM50217665
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|
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| Activity |
Ki = 99000 nM
|
[2] | |||
| Compound Name |
CID 137639140
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072638; BDBM50263393
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083048; BDBM50263851
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429742; BDBM50372556
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2R)-2-Amino-N-[(2R)-5-(diaminomethylideneamino)-1-phenylpentan-2-yl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258295; BDBM50372554
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|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[(1R,4S,7S,13S,16S,19R,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-14,17-dimethyl-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102353; BDBM50263839
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256630; BDBM50372553
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|
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
CID 137659949
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097903; BDBM50263381
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
CID 137651025
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079142; BDBM50263383
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(3-Aminopropyl)-N-(1-(benzo[b]thiophen-3-yl)ethyl)-4-(1H-indol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394149; BDBM50217639
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||||
| Activity |
Ki = 104000 nM
|
[2] | |||
| Compound Name |
N-(1H-Indole-3-ylmethyl)-1-(1-naphthylmethyl)-D-prolinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093089; BDBM50451495
Click to Show/Hide
|
||||
| Activity |
Ki = 104000 nM
|
[1] | |||
| Compound Name |
(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(1H-indol-3-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235355; BDBM50217758
Click to Show/Hide
|
||||
| Activity |
Ki = 106000 nM
|
[2] | |||
| Compound Name |
2-(4-Hydroxybenzyl)-N-(4-aminobutyl)-N-isopropyl-1H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236629; BDBM50217752
Click to Show/Hide
|
||||
| Activity |
Ki = 106000 nM
|
[2] | |||
| Compound Name |
Nalpha-(2-Naphthylmethyl)-L-Arg-L-Trp-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8720; MK-29A; BDBM50111180
Click to Show/Hide
|
||||
| Activity |
Ki = 107000 nM
|
[1] | |||
| Compound Name |
N-(4-Aminobutyl)-N-isopropyl-1H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396179; BDBM50217668
Click to Show/Hide
|
||||
| Activity |
Ki = 112000 nM
|
[2] | |||
| Compound Name |
N-[(2R)-3-(4-Chlorophenyl)-1-(4-cyclohexyl-4-oxidopiperazin-4-ium-1-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363757; BDBM50151508
Click to Show/Hide
|
||||
| Activity |
Ki = 114000 nM
|
[10] | |||
| Compound Name |
N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-(1H-indol-3-yl)-N-[(2-methylphenyl)methyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391944; BDBM50217638
Click to Show/Hide
|
||||
| Activity |
Ki = 121000 nM
|
[2] | |||
| Compound Name |
N-(2-Aminoethyl)-3-(1H-indol-3-yl)-N-(3-phenylpropyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396655; BDBM50217790
Click to Show/Hide
|
||||
| Activity |
Ki = 127000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238180; BDBM50217768
Click to Show/Hide
|
||||
| Activity |
Ki = 131000 nM
|
[2] | |||
| Compound Name |
N-(3-Bromo-4-methoxybenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237688; BDBM50217687
Click to Show/Hide
|
||||
| Activity |
Ki = 132000 nM
|
[2] | |||
| Compound Name |
N-(2-Aminoethyl)-N-(naphthalen-2-ylmethyl)-1H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235797; BDBM50217716
Click to Show/Hide
|
||||
| Activity |
Ki = 134000 nM
|
[2] | |||
| Compound Name |
N-(4-Guanidino-butyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236022; SCHEMBL7858101; BDBM50217732; N-[4-(diaminomethylideneamino)butyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
Click to Show/Hide
|
||||
| Activity |
Ki = 134000 nM
|
[2] | |||
| Compound Name |
N-(4-Guanidino-butyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393532; SCHEMBL7864892; BDBM50217723; N-[4-(diaminomethylideneamino)butyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
Click to Show/Hide
|
||||
| Activity |
Ki = 137000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-1H-indole-3-methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8552; BDBM50111164; AKOS011608229; N*1*-(1H-Indol-3-ylmethyl)-propane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
Ki = 145000 nM
|
[6] | |||
| Compound Name |
N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-{2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl}-N-[(4-methylphenyl)methyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394667; BDBM50217779
Click to Show/Hide
|
||||
| Activity |
Ki = 147000 nM
|
[2] | |||
| Compound Name |
Nalpha-(2-Naphthylmethyl)-D-Arg-L-Trp-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447178; MK-30A; BDBM50111179
Click to Show/Hide
|
||||
| Activity |
Ki = 147000 nM
|
[1] | |||
| Compound Name |
(S)-5-Guanidino-2-[(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amino]-pentanoic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8676; MK-28; BDBM50111185
Click to Show/Hide
|
||||
| Activity |
Ki = 155000 nM
|
[1] | |||
| Compound Name |
N2-(2-Naphthylmethyl)-L-ornithine allyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MK-42; CHEMBL1159703
Click to Show/Hide
|
||||
| Activity |
Ki = 161000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-4-Hydroxy-N-[2-(1H-imidazol-5-yl)ethyl]-1-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9048; MK-69; BDBM50111189; N-[2-(1H-Imidazole-4-yl)ethyl]-1-(2-naphthylmethyl)-4alpha-hydroxy-L-prolinamide
Click to Show/Hide
|
||||
| Activity |
Ki = 161000 nM
|
[1] | |||
| Compound Name |
(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(4-nitrophenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393382; BDBM50217755
Click to Show/Hide
|
||||
| Activity |
Ki = 162000 nM
|
[2] | |||
| Compound Name |
N-(4-Aminobutyl)-N2-(2-naphthylmethyl)-N6-(1H-indole-3-ylmethyl)-L-lysinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8418; BDBM50111172
Click to Show/Hide
|
||||
| Activity |
Ki = 167000 nM
|
[6] | |||
| Compound Name |
N-(4-((4-Aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)-N-(pyridin-4-ylmethyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235139; BDBM50217680
Click to Show/Hide
|
||||
| Activity |
Ki = 172000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-N-cinnamyl-1H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237957; BDBM50217718
Click to Show/Hide
|
||||
| Activity |
Ki = 172000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 22 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(4-(Methylthio)benzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394645; BDBM50217630
Click to Show/Hide
|
||||
| Activity |
Ki = 201000 nM
|
[2] | |||
| Compound Name |
N-(2-Guanidino-ethyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235590; SCHEMBL7866522; BDBM50217664; N-[2-(diaminomethylideneamino)ethyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
Click to Show/Hide
|
||||
| Activity |
Ki = 204000 nM
|
[2] | |||
| Compound Name |
(1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8208; BDBM50111162; N-(1-Naphthylmethyl)-1H-indole-3-methanamine
Click to Show/Hide
|
||||
| Activity |
Ki = 214000 nM
|
[6] | |||
| Compound Name |
N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-(1H-indol-3-yl)-N-[(4-methylphenyl)methyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237504; BDBM50217659
Click to Show/Hide
|
||||
| Activity |
Ki = 220000 nM
|
[2] | |||
| Compound Name |
N-(3-Guanidino-propyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235592; SCHEMBL7869175; BDBM50217675; N-[3-(diaminomethylideneamino)propyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
Click to Show/Hide
|
||||
| Activity |
Ki = 228000 nM
|
[2] | |||
| Compound Name |
N-(4-(Methylthio)benzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237290; BDBM50217756
Click to Show/Hide
|
||||
| Activity |
Ki = 249000 nM
|
[2] | |||
| Compound Name |
N-(4-((4-Aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393568; BDBM50217714
Click to Show/Hide
|
||||
| Activity |
Ki = 278000 nM
|
[2] | |||
| Compound Name |
N-(4-(Diethylamino)benzyl)-4-(1H-indol-3-yl)-N-pentylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237478; BDBM50217774
Click to Show/Hide
|
||||
| Activity |
Ki = 289000 nM
|
[2] | |||
| Compound Name |
(R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-carbamoyl)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8287; BDBM50111157
Click to Show/Hide
|
||||
| Activity |
Ki = 294000 nM
|
[6] | |||
| Compound Name |
N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-{2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl}-N-[(2-methylphenyl)methyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236639; BDBM50217742
Click to Show/Hide
|
||||
| Activity |
Ki = 349000 nM
|
[2] | |||
| Compound Name |
N-(3-Aminopropyl)-5-(benzyloxy)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237479; BDBM50217635
Click to Show/Hide
|
||||
| Activity |
Ki = 542000 nM
|
[2] | |||
| Compound Name |
(2R)-1-[2-(1H-Indol-3-yl)ethyl]-N-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113644; MK-50; BDBM50451496; N-(2-Naphthylmethyl)-1-[2-(1H-indole-3-yl)ethyl]-D-prolinamide
Click to Show/Hide
|
||||
| Activity |
Ki = 752000 nM
|
[1] | |||
| Compound Name |
(1R,4S,6R)-N-[(2R)-1-[4-(Tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-7-methyl-7-azabicyclo[2.2.2]octane-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RY764; RY-764; CHEMBL364346; GTPL1337; SCHEMBL14040521; BDBM50169442; RY 764; Q27088656
Click to Show/Hide
|
||||
| Activity |
IC50 = 942000 nM
|
[11] | |||
| Compound Name |
4-(2-Naphthylmethyl)-1-piperazinecarboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8561; BDBM50111168; 4-Naphthalen-2-ylmethyl-piperazine-1-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[6] | |||
| Compound Name |
(R)-2-[(1H-Indol-3-ylmethyl)-amino]-3-naphthalen-2-yl-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9219; MK-15; BDBM50111188; Nalpha-(1H-Indole-3-ylmethyl)-3-(2-naphthyl)-D-alaninamide
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
(S)-2-[(1H-Indol-3-ylmethyl)-amino]-3-naphthalen-2-yl-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428480; MK-16; BDBM50111197; Nalpha-(1H-Indole-3-ylmethyl)-3-(2-naphthyl)-L-alaninamide
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
3-(Piperazin-1-ylmethyl)-1H-indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Piperazin-1-ylmethyl-1H-indole; CHEMBL276397; 1H-Indole,3-(1-piperazinylmethyl)-; ACMC-1C6NR; SCHEMBL948663; CTK4A8882; ALBB-009662; 1-(1H-Indole-3-ylmethyl)piperazine; BDBM50111159; STK505991; ZINC22924625; AKOS005172105; QC-9778; AC-26732; AB0097921; FT-0723189; 746P666; 1H-indole, 3-(1-piperazinylmethyl)-, hydrochloride
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[6] | |||
| Compound Name |
4-(1H-Indole-3-ylmethyl)-1-piperazinecarboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8598; BDBM50111171; 4-(1H-Indol-3-ylmethyl)-piperazine-1-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[6] | |||
| Compound Name |
(R)-5-Guanidino-2-[(naphthalen-2-ylmethyl)-amino]-pentanoic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266055; MK-20; BDBM50111196; Nalpha-(2-Naphthylmethyl)-D-argininamide
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
N-(1-Naphthylmethyl)-N-(2-naphthylmethyl)amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8129; Oprea1_758708; MLS000859006; HMS2798P17; ZINC4343360; BDBM50111163; MCULE-1376042569; SMR000459185; N-(2-Naphthylmethyl)-1-naphthalenemethanamine; Naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-amine
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[6] | |||
| Compound Name |
Nalpha-(1H-Indole-3-ylmethyl)-L-Arg-L-Trp-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267007; MK-29B; BDBM50111190
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
1-(Naphthalen-2-ylmethyl)piperazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8756; 1-Naphthalen-2-ylmethyl-piperazine; Oprea1_775617; SCHEMBL593143; 1-(2-naphthylmethyl)-piperazine; 1-(beta-napthylmethyl)piperazine; CTK2E5435; DTXSID20358696; BDBM50111166; STL321465; ZINC20790799; AKOS009158679; 1-(2-NAPHTHYLMETHYL)PIPERAZINE; 1-[(naphthalen-2-yl)methyl]piperazine; MCULE-4088318939; NE51610; Piperazine, 1-(2-naphthalenylmethyl)-; DB-110844; BB 0249443; EN300-81737; Z1250089962
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N-alkylaminoacids and their derivatives interact with melanocortin receptors. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1039-42. | ||||
| REF 2 | Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem. 2007 Sep 1;15(17):5787-810. | ||||
| REF 3 | Peptoid mimics of agouti related protein. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1409-13. | ||||
| REF 4 | Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1223-8. | ||||
| REF 5 | QSAR and proteo-chemometric analysis of the interaction of a series of organic compounds with melanocortin receptor subtypes. J Med Chem. 2003 Jun 19;46(13):2572-9. | ||||
| REF 6 | Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1035-8. | ||||
| REF 7 | Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. J Med Chem. 2018 Apr 26;61(8):3674-3684. | ||||
| REF 8 | Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. | ||||
| REF 9 | Human -Defensin 1 and -Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors. J Med Chem. 2018 Apr 26;61(8):3738-3744. | ||||
| REF 10 | New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J Med Chem. 2004 Aug 26;47(18):4613-26. | ||||
| REF 11 | Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxo... Bioorg Med Chem Lett. 2005 Aug 1;15(15):3501-5. | ||||
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