Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76522 | Target Info | |||
| Target Name | Pyridoxal kinase (PDXK) | ||||
| Synonyms |
Pyridoxine kinase; PDXK
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| Target Type | Literature-reported Target | ||||
| Gene Name | PDXK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Pyridinemethanol, 6-ethenyl-5-hydroxy-4-methyl-, hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3244690; CTK2F0719; DTXSID10822179; BDBM50009721; 2-Ethenyl-5-(hydroxymethyl)-4-methylpyridin-3-ol--hydrogen chloride (1/1)
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| Activity |
Ki = 68100 nM
|
[1] | |||
| Compound Name |
2-Ethynyl-4,5-bis(hydroxymethyl)pyridin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3245268; BDBM50009724
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| Activity |
Ki = 105000 nM
|
[2] | |||
| Compound Name |
4-Ethynyl-5-(hydroxymethyl)-2-methylpyridin-3-OL
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3275146; BDBM50016820; AKOS006237865
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| Activity |
Ki = 125000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Antagonists of vitamin B6. Simultaneous and stepwise modification of the 2 and 4 positions. J Med Chem. 1977 Jan;20(1):1-5. | ||||
| REF 2 | Vitamin B6 antagonists obtained by replacing or modifying the 2-methyl group. J Med Chem. 1977 Jun;20(6):745-9. | ||||
| REF 3 | 4-Halovinyl- and 4-ethynyl-4-deformylpyridoxal derivatives and related analogues as potentially irreversible antagonists of vitamin B6. J Med Chem. 1977 Apr;20(4):567-72. | ||||
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