Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76396 | Target Info | |||
| Target Name | Geranylgeranyl transferase I (GGTase-I) | ||||
| Synonyms |
Type I protein geranyl-geranyltransferase subunit beta; Type I protein geranyl-geranyltransferase beta subunit of Saccharomyces cerevisiae; RAS proteins geranylgeranyltransferase beta subunit; PGGT; Geranylgeranyl transferase type-1 subunit beta; Geranylgeranyl transferase type I subunit beta; GGTase-I-beta of Saccharomyces cerevisiae; GGTase-I-beta; CDC43
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| Target Type | Clinical trial Target | ||||
| Gene Name | PGGT1B | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(5-{[1-(2-Mercapto-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL430478; BDBM50103364
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
4-(5-{[1-(2-Methyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL317129; BDBM50103324
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-4-((5-(((1-Benzyl-2-oxopyrrolidin-3-yl)(pyridin-3-ylmethyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327946; BDBM50103335
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[5-[[3-Aminopropyl[(3S)-1-(3-chlorobenzyl)-2-oxo-3-pyrrolidinyl]amino]methyl]-1H-imidazole-1-ylmethyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98147; BDBM50103336
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[5-[[2-Piperazinoethyl[(3S)-1-(3-chlorobenzyl)-2-oxo-3-pyrrolidinyl]amino]methyl]-1H-imidazole-1-ylmethyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101788; BDBM50103346
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(5-{[1-(2-Amino-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99323; BDBM50103355
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
4-[5-[[3-Aminopropyl[(3S)-1-benzyl-2-oxo-3-pyrrolidinyl]amino]methyl]-1H-imidazole-1-ylmethyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322007; BDBM50103350
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(5-{[1-(2-Hydroxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101509; BDBM50103345
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(5-{[1-(2-Methoxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101106; BDBM50103344
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(5-{[1-(Pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99650; BDBM50103359
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(8-Quinolinyl)-4-[1-hydroxy-1-(1-methyl-1H-imidazole-5-yl)-3-(4-cyanophenyl)-2-propynyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL24159; BDBM50126025
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| Activity |
IC50 = 83000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. J Med Chem. 2001 Aug 30;44(18):2933-49. | ||||
| REF 2 | Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1293-6. | ||||
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