Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T74607 | Target Info | |||
Target Name | Rap guanine nucleotide exchange factor 4 (EPAC2) | ||||
Synonyms |
cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFII; Exchange protein directly activated by cAMP 2; Exchange factor directly activated by cAMP 2; EPAC2; EPAC 2; CGEF2
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Target Type | Literature-reported Target | ||||
Gene Name | RAPGEF4 | ||||
UniProt ID |
Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
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Compound Name |
2-(2,5-Dimethyl-Benzylsulfanyl)-4-(1-Methyl-Piperidin-4-Yl)-6-Oxo-1,6-Dihydro-Pyrimidine-5-Carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030614; SCHEMBL15188825; BDBM50384275
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Activity |
IC50 = 127000 nM
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[1] |
Non Binders of This Target (in total, 19 non binders) | Download | Top | |||
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Compound Name |
2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2,4,6-trimethylphenyl)acetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030620; SCHEMBL15174498; BDBM50384279
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
2-(4-Cyclohexyloxyphenyl)sulfonyl-1,3,5-trimethylbenzene
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313661; SCHEMBL15175326; BDBM50425547; 2-(4-Cyclohexyloxy-Benzenesulfonyl)-1,3,5-Trimethyl-Benzene
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
(4,5-Dimethyl-Thiazol-2-Yl)-(2,4,6-Trimethyl-Phenyl)-Amine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313638; SCHEMBL15188851; BDBM50425540; 4,5-dimethyl-N-(2,4,6-trimethylphenyl)-1,3-thiazol-2-amine
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
4-[4-(2,4,6-Trimethylphenyl)sulfonylphenoxy]piperidine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313633; SCHEMBL15174484; BDBM50425545
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-phenylacetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030619; SCHEMBL15188826; BDBM50384281
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
2-[4-(2,4,6-Trimethylphenyl)sulfonylphenoxy]ethanamine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313634; SCHEMBL15174333; BDBM50425544; 2-[4-(2,4,6-Trimethyl-Benzenesulfonyl)-Phenoxy]-Ethylamine
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
Tert-butyl 4-[4-(2,4,6-trimethylphenyl)sulfonylphenoxy]piperidine-1-carboxylate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313662; SCHEMBL15188814; BDBM50425546; 4-[4-(2,4,6-Trimethyl-Benzenesulfonyl)-Phenoxy]-Piperidine-1-Carboxylic Acid Tert-Butyl Ester
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
2-Fluoro-5-[4-(2,4,6-trimethylphenyl)sulfonylphenyl]pyridine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313659; SCHEMBL15174028; BDBM50425549; 2-Fluoro-5-[4-(2,4,6-Trimethyl-Benzenesulfonyl)-Phenyl]-Pyridine
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
2-(4-Cyclohexylphenyl)sulfonyl-1,3,5-trimethylbenzene
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313656; SCHEMBL15188839; BDBM50425552; 2-(4-Cyclohexyl-Benzenesulfonyl)-1,3,5-Trimethyl-Benzene
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030618; SCHEMBL15174245; BDBM50384263
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
Methyl 1-(2,4,6-trimethylphenyl)sulfonylindole-5-carboxylate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313647; SCHEMBL15188844; BDBM50425530; 1-(2,4,6-Trimethyl-Benzenesulfonyl)-1H-Indole-5-Carboxylic Acid Methyl Ester
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
2-Ethyl-1-[4-(trifluoromethyl)phenyl]sulfonylpyrrole
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313642; SCHEMBL15173806; BDBM50425535; 2-Ethyl-1-(4-Trifluoromethyl-Benzenesulfonyl)-1H-Pyrrole
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Activity |
IC50 > 300000 nM
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[2] | |||
Compound Name |
2-Anilino-6-cyclohexyl-4-oxo-1H-pyrimidine-5-carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030616; SCHEMBL15174766; BDBM50384277; 4-Cyclohexyl-6-Oxo-2-Phenylamino-1,6-Dihydro-Pyrimidine-5-Carbonitrile
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
2-(4-Chloroanilino)-6-cyclohexyl-4-oxo-1H-pyrimidine-5-carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030617; SCHEMBL15174524; BDBM50384278; 2-(4-Chloro-Phenylamino)-4-Cyclohexyl-6-Oxo-1,6-Dihydro-Pyrimidine-5-Carbonitrile
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
2,4,6-Trimethyl-N-[3-[2-(2,4,6-trimethylphenyl)ethynyl]phenyl]aniline
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3809981; BDBM50175144
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Activity |
IC50 > 300000 nM
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[3] | |||
Compound Name |
2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030621; SCHEMBL15174335; BDBM50384280
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
5-Cyano-6-cyclohexyl-2-thiouracil
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Investigative | Compound Info | ||
Synonyms |
4-CYCLOHEXYL-2-MERCAPTO-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE; 6-cyclohexyl-4-oxo-2-sulfanylidene-1H-pyrimidine-5-carbonitrile; CHEMBL2030605; 6-cyclohexyl-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile; 6-Cyclohexyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile; Maybridge1_006482; SCHEMBL15188821; SCHEMBL17550133; CTK4G2607; CTK7C6119; HMS559O14; DTXSID70370984; ZINC2555819; BDBM50384266; CCG-40640; MFCD01312949; AS-9165; MCULE-8195078067; VZ30272; DB-047507; FT-0618315; A819725; SR-01000630768-1; BRD-K26471830-001-01-2; 4-Cyclohexyl-2-Mercapto-6-Oxo-1,6-Dihydro-Pyrimidine-5-Carbonitrile; 6-cyclohexyl-4-oxidanylidene-2-sulfanylidene-1H-pyrimidine-5-carbonitrile
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
2-(2,5-Dimethylbenzylsulfanyl)-6-Oxo-4-Piperidin-4-Yl-1,6-Dihydro-Pyrimidine-5-Carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2030615; SCHEMBL15173944; BDBM50384276; 2-[(2,5-dimethylphenyl)methylsulfanyl]-4-oxo-6-piperidin-4-yl-1H-pyrimidine-5-carbonitrile
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Activity |
IC50 > 300000 nM
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[1] | |||
Compound Name |
1,3,5-Trimethyl-2-(4-pentylphenyl)sulfonylbenzene
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313655; SCHEMBL16652571; BDBM50425553; 1,3,5-Trimethyl-2-(4-Pentyl-Benzenesulfonyl)-Benzene
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Activity |
IC50 > 300000 nM
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[2] | |||
Click to Show/Hide the Information of All Non Binders |
References | Top | ||||
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REF 1 | 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. | ||||
REF 2 | Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62. | ||||
REF 3 | Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors. ACS Med Chem Lett. 2016 Mar 28;7(5):460-4. |
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