Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T73696 | Target Info | |||
| Target Name | Relaxin receptor 1 (RXFP1) | ||||
| Synonyms |
Relaxin family peptide receptor 1; RXFP1; Leucine-rich repeat-containing G-protein coupled receptor 7
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| Target Type | Clinical trial Target | ||||
| Gene Name | RXFP1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2-Methoxyethylamino)-N-[3-(trifluoromethyl)phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3715266; SCHEMBL15529123; BDBM50449885; NCGC00244512-01
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| Activity |
EC50 = 59300 nM
|
[1] | |||
| Compound Name |
2-(Cyclohexanecarbonylamino)-N-[4-(trifluoromethyl)phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3717485; SCHEMBL15530329; BDBM50449863; NCGC00189480-01
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| Activity |
EC50 = 94000 nM
|
[1] | |||
| Compound Name |
2-[(Cyclohexylcarbonyl)amino]-N-phenylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1491180; 2-(cyclohexanecarbonylamino)-N-phenylbenzamide; Cambridge id 6953510; Oprea1_371200; Oprea1_860910; MLS000575775; ARONIS001724; SCHEMBL15528295; HMS2325J24; ZINC142523; KS-00003V4F; BDBM50449864; STK058230; AKOS000491383; NCGC00189487-01; SMR000196810; ST039925; [2-(cyclohexylcarbonylamino)phenyl]-N-benzamide; AN-329/40925136
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| Activity |
EC50 = 94000 nM
|
[1] | |||
| Compound Name |
2-(Cyclohexanecarbonylamino)-N-(4-methylphenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3716352; SCHEMBL15528361; BDBM50449866; NCGC00189477-01
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| Activity |
EC50 = 187000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem. 2018 Aug 5;156:79-92. | ||||
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