Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T73475 | Target Info | |||
| Target Name | Matrix metalloproteinase-7 (MMP-7) | ||||
| Synonyms |
Uterine metalloproteinase; Pump-1 protease; PUMP1; Matrin; Matrilysin; MPSL1
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| Target Type | Successful Target | ||||
| Gene Name | MMP7 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 53 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1607004-34-1
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|
Patented | Compound Info | ||
| Synonyms |
ADAMTS Inhibitor C7; SCHEMBL15692551; CHEMBL3980860; BDBM194644; 1607004-34-1; US9206139, 3
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
US9206139, 4
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Patented | Compound Info | ||
| Synonyms |
CHEMBL3955404; SCHEMBL15692527; BDBM194645; US9206139, 4
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
US9206139, 5
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL15692518; CHEMBL3972836; BDBM194646; US9206139, 5
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176517; 219311-20-3; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(4-phenoxyphenyl)-; SCHEMBL6380971; CTK0J6997; DTXSID60470422; NNRYJLARUIVRRO-UHFFFAOYSA-N; 5-(4'-phenoxyphenyl)barbituric acid; 5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Methyl-5-phenyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
Heptobarbital; Mephebarbital; Eudan; Phenylmethylbarbituric acid; Rutonal; Methylphenylbarbital; 5-Methyl-5-phenylbarbituric acid; 5-Methyl-5-phenylbarbityric acid; 76-94-8; 5-Phenyl-5-methylbarbituric acid; NSC 80543; Barbituric acid, 5-methyl-5-phenyl-; UNII-GFR227X6YY; 5-Methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; EINECS 200-994-8; BRN 0201825; GFR227X6YY; CHEMBL329617; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-methyl-5-phenyl-; 5-methyl-5-phenyl-barbituric acid; C11H10N2O3; 5-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
5-Hexyl-5-phenylbarbituric acid; BRN 0297956; BARBITURIC ACID, 5-HEXYL-5-PHENYL-; 67051-21-2; CHEMBL173075; AC1L2LKK; 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione; 4-24-00-02103 (Beilstein Handbook Reference); CTK8J9653; DTXSID20217355; 5-hexyl-5-phenyl barbituric acid; BDBM50099125; LS-24512
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
ARP100
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Investigative | Compound Info | ||
| Synonyms |
ARP 100; ARP-100
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175282; 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione; BDBM50099116
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL367524; 94209-48-0; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[1,1'-biphenyl]-4-yl-5-ethyl-; ACMC-20lyhc; AC1M3WRE; Oprea1_691960; MLS001000776; 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione; NIOSH/CQ0532020; CTK3G9325; DTXSID20367041; MolPort-002-095-507; HMS2827O03; BDBM50099119; ZINC96299878; STK760260; AKOS005616072; MCULE-2406616532; Acido 5-etil 5-(p-difenilil)barbiturici; NCGC00245692-01; 5-(4-Biphenylyl)-5-ethylbarbituric acid; SMR000498104; LS-23825; M.G. 3419; CQ05320200; Barbituric acid, 5-(4-biphenylyl)-5-ethyl-
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572982; (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid; SCHEMBL5613354; ILGSIIFHQGOKKV-UHFFFAOYSA-N; BDBM50300465; 5-biphenyl-4-yl-3-hydroxy-pentanoic acid; 5-(biphenyl-4-yl)-3-hydroxypentanoic acid
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| Activity |
IC50 ~ 98000 nM
|
[4] | |||
| Compound Name |
N1,N3-bis(3-methoxybenzyl)isophthalamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605201; N1,N3-bis(3-methoxybenzyl)isophthalamide; SCHEMBL5332068
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Methotrexate gamma-hydroxamic acid
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Investigative | Compound Info | ||
| Synonyms |
methotrexate gamma-hydroxamic acid; CHEMBL244883
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
Bb-3497
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Investigative | Compound Info | ||
| Synonyms |
BB-3497; CHEMBL431210; BB 3497; 235784-88-0; 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC ACID (1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE; (2r)-n-[(2s)-1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-{[formyl(hydroxy)amino]methyl}hexanamide; BB1; 1g27; (2R)-N-[(2S)-1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide; AC1L4M3L; AC1Q5HZ8; SCHEMBL13754309; DTXSID80178216; BDBM50104501; BB3497; DB04368; (R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Thioxo-5-hexyl-5-(4-biphenylyl)hexahydropyrimidine-4,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176876; BDBM50099122; 5-Biphenyl-4-yl-5-hexyl-2-thioxo-dihydro-pyrimidine-4,6-dione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Benzyloxymethyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177740; SCHEMBL6814140; BDBM50099121; 5-(4-phenoxyphenyl)-5-(phenylmethoxymethyl)-1,3-diazinane-2,4,6-trione; 5-(Benzyloxymethyl)-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Hexyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176832; SCHEMBL6813840; 5-hexyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione; BDBM50099123; 5-Hexyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione; 5-n-hexyl-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-(2-Hydroxyethyl)-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL174641; SCHEMBL6810540; 5-(2-hydroxyethyl)-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione; BDBM50099120; 5-(2-Hydroxy-ethyl)-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2R,3R)-4-(2-(3-Chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxo-N-(2-(thiophen-2-yl)ethyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590343; SCHEMBL8217068; BDBM50309147
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
1,5-Dimethyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL366956; SCHEMBL6810545; BDBM50099124; 1,5-Dimethyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione; 1,5-dimethyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Methyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione
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|
Investigative | Compound Info | ||
| Synonyms |
5-methyl-5-(4-phenoxyphenyl)barbituric acid; CHEMBL176467; 5-methyl-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-methyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione; SCHEMBL4321603; CTK0J1794; DTXSID10274336; BDBM50099118; DB03368; Q27094311; 5-Methyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-methyl-5-(4-phenoxyphenyl)-
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[(1S,2S)-2-Sulfanylcyclopentyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380393; BDBM50433874
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| Activity |
Ki ~ 50000 nM
|
[9] | |||
| Compound Name |
[(R)-2-Methyl-1-(4-phenethyl-benzenesulfonylamino)-propyl]-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227553; BDBM50198032; ZINC28640034
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
(2R,3R)-N-(Benzofuran-2-ylmethyl)-2,3-dihydroxy-4-oxo-4-(2-phenylpyrrolidin-1-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591774; SCHEMBL8219481; BDBM50309153
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
5-Methyl-5-(4-octyloxy-benzyl)-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177077; BDBM50099117; 5-Methyl-5-[4-(octyloxy)benzyl]hexahydropyrimidine-2,4,6-trione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-3-Methyl-2-(8-(thiazol-2-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1935291; SCHEMBL3081114; BDBM50360969; (2S)-3-methyl-2-[[8-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid
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| Activity |
IC50 = 57700 nM
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[11] | |||
| Compound Name |
(2r,3r)-4-[4-(2-Chlorophenyl)piperazin-1-Yl]-2,3-Dihydroxy-4-Oxo-N-(2-Thiophen-2-Ylethyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605764; SCHEMBL8216976; BDBM50309132; Q27454292
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| Activity |
Ki ~ 60000 nM
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[8] | |||
| Compound Name |
Biphenylsulfonamide carboxylate, 9
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43147; BDBM24032; N-(biphenyl-4-ylsulfonyl)-l-valine; ZINC13803822; N-(1,1'-Biphenyl-4-ylsulfonyl)valine; (2S)-3-methyl-2-[(4-phenylbenzene)sulfonamido]butanoic acid
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| Activity |
IC50 = 71000 nM
|
[12] | |||
| Compound Name |
4''-Methylepigallocatechin gallate
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Investigative | Compound Info | ||
| Synonyms |
UNII-CUX41G3911; CHEMBL559294; (-)-Epigallocatechin 3-(4-methyl-gallate); CUX41G3911; Egcg4''me; NSC714028; Epigallocatechin-3-O-(4-O-methyl)gallate; 4''-O-methyl-EGCG; (-)-Epigallocatechin 3-(4''-O-methyl) gallate; 4''-O-Methyl-(-)-epigallocatechin-3-o-gallate; (-)-EPIGALLOCATECHIN 3-(4''-O-METHYL)GALLATE; SCHEMBL16887923; CTK6J4412; 4-O-Methylgalloyl epigallocatechin; BDBM50296235; Epigallocatechin 3-(4-methylgallate); NSC-714028; Epigallocatechin 3-O-(4-methylgallate); 3-O-(4-O-Methylgalloyl)epigallocatechin; NCI60_039612; 4'-Methyl-(-)-epigallocatechin 3-gallate; 4''-O-Methylepigallocatechin 3-O-gallate; (-)-Epigallocatechin-3-(4''''-O-methyl)gallate; Q27275816
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| Activity |
IC50 = 72000 nM
|
[13] | |||
| Compound Name |
2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]acetic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44898; SCHEMBL7870635; BDBM50084304; ZINC13803841; (4''-Bromo-biphenyl-4-sulfonylamino)-acetic acid
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| Activity |
IC50 = 77000 nM
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[12] | |||
| Compound Name |
alpha-Arylsulfonylamino hydroxamate 3S
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43644; BDBM12077; (2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-hydroxy-3-methylbutanamide; (S)-N-Hydroxy-3-methyl-2-[[(4'-bromo-1,1'-biphenyl-4-yl)sulfonyl]amino]butanamide
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| Activity |
IC50 = 78000 nM
|
[12] | |||
| Compound Name |
2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane
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Investigative | Compound Info | ||
| Synonyms |
SB-3CT; 2-((4-phenoxyphenylsulfonyl)methyl)thiirane; SB3CT; SB 3CT; CHEMBL483857; 2-(((4-Phenoxyphenyl)sulfonyl)methyl)thiirane; Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-; 2-[(4-PHENOXYBENZENESULFONYL)METHYL]THIIRANE; MMP-2/MMP-9 Inhibitor IV; 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane; 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-Thiirane; Thiirane, 1; (4-phenoxyphenylsulfonyl)methylthiirane; MLS006010722; Thiirane (deuterium), 1-d2; GTPL9509; SCHEMBL2684163; CTK8F0499; KS-00001CWI; AOB6468; DTXSID70432359; EX-A687; C15H14O3S2; HMS3653B03; BCP10428; 2705AH; BDBM50264809; MFCD09836266; s7430; AKOS026750307; CCG-267539; CS-3445; inhibitor 1 (Brown et al., 2000); SB-3CT, >=98% (HPLC), powder; NCGC00346932-01; 2-(4-phenoxyphenylsulfonylmethyl)thiirane; AC-32656; AK270339; AS-67674; HY-12354; SMR004701685; DS-015900; FT-0700278; SW219838-1; 2-[[4-(phenoxy)phenyl]sulfonylmethyl]thiirane; J-017452; Q27165480
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| Activity |
Ki = 96000 nM
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[14] | |||
| Compound Name |
N-[(2S)-1-(Dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL84969; BB-3554; SCHEMBL4956500; BDBM50104500; 2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072836; SCHEMBL15692522; BDBM194639; US9206139, 2
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Epicatechin 3-O-(4-O-methylgallate)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL159433; (-)-ECG-4''-O-ME; CTK6J4413; 3-O-(4-Methylgalloyl)epicatechin; Epicatechin 3-O-(4-methylgallate); BDBM50296237; LMPK12020094
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(4-cyclohexylbutyl)thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437163; BDBM50441574
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| Activity |
IC50 ~ 100000 nM
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[15] | |||
| Compound Name |
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066965; SCHEMBL15692521; BDBM194638; US9206139, 1
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-Phenoxy-N-[(1S,2R)-2-sulfanylcyclopentyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380392; BDBM50433875
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(4S)-5-[[(2S)-1-Amino-3-carboxy-1-oxopropan-2-yl]amino]-5-oxo-4-[3-[4-(4-phenylthiophen-2-yl)phenyl]propanoylamino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6868749; CHEMBL3675599; BDBM120252; US8691753, 101
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| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4-dihydroxy-5-methoxybenzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL556277; BDBM50296240
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Epicatechin 3-O-(3-O-methylgallate)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158521; (-)-ECG-3''-O-ME; (-)-Epicatechin-3-(3''-O-methyl) gallate; CTK6J6178; 3-O-(3-Methylgalloyl)epicatechin; Epicatechin 3-(3-O-methylgallate); BDBM50296236; epicatechin 3-(3'-O-methylgallate); LMPK12020093; ZINC14642643; epicatechin 3-O-(3'-O-methylgallate); (-)-epicatechin 3-(3'-O-methylgallate); (-)-epicatechin 3-O-(3'-O-methylgallate)
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,5-dihydroxy-4-methoxybenzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL556692; BDBM50296241
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(3''-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43206; SCHEMBL7409278; BDBM50084299; (S)-2-(3''-bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(3-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
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| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
(2S)-2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43276; SCHEMBL4422490; BDBM50084284; 2-(4''-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-propionic acid
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||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
PD-503; CHEMBL409536; SCHEMBL5957461; PD503; BDBM50234334; ZINC29133346; DB08561; Q27097766
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380404
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||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(2beta-Mercaptocyclopentane-1alpha-yl)-4-phenoxybenzenesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380395; BDBM50433872
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||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Hydroxamate deriv., 78
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|
Investigative | Compound Info | ||
| Synonyms |
BMCL1954 Compound 3; CHEMBL269834; SCHEMBL8357412; BDBM23487
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|
||||
| Activity |
Ki = 110000 nM
|
[19] | |||
| Compound Name |
2-Amino-5-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834423; SCHEMBL2369869; BDBM50354625; 2-amino-5-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenol
Click to Show/Hide
|
||||
| Activity |
Ki = 116000 nM
|
[20] | |||
| Compound Name |
4-(Thiiran-2-ylmethylsulfonyl)phenyl propane-2-sulfonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651849; BDBM50335502
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|
||||
| Activity |
Ki = 120000 nM
|
[14] | |||
| Compound Name |
(1R,2S)-1-({3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461220; SCHEMBL13648029; BDBM26524; hydroxamate-cyclopropyl compound, 1
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|
||||
| Activity |
Ki = 128000 nM
|
[19] | |||
| Compound Name |
((R)-1-{4-[2-(4-Methoxy-phenyl)-ethyl]-benzenesulfonylamino}-2-methyl-propyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228141; BDBM50198036
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[10] | |||
| Compound Name |
(2S)-2-Amino-5-(diaminomethylideneamino)-N-[4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834420; BDBM50354627
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|
||||
| Activity |
Ki = 160000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Phenoxy-N-[(1R,2S)-2-sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380391; BDBM50433876
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[9] | |||
| Compound Name |
(3S,4S)-3-(4-Phenoxybenzenesulfonamido)-4-mercaptopyrrolidine Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380399; SCHEMBL1973277
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|
||||
| Activity |
Ki > 200000 nM
|
[9] | |||
| Compound Name |
N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380397; BDBM50433870
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[9] | |||
| Compound Name |
MMP-2/MMP-9 Inhibitor V
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445971; N-[4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanesulfonamide; SB-3CT, pMS; N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)methanesulfonamide; SCHEMBL315716; CTK8G1146; (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane; BDBM50264810
Click to Show/Hide
|
||||
| Activity |
Ki = 295000 nM
|
[3] | |||
| Compound Name |
L-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445994; h-leu-phe-nhme, AldrichCPR; SCHEMBL7330972; ZINC2386645; BDBM50245250; MFCD01862383; L-leucyl-L-phenylalanine N-methylamide; (2S)-2-AMINO-4-METHYL-N-[(1S)-1-(METHYLCARBAMOYL)-2-PHENYLETHYL]PENTANAMIDE; (2S)-2-amino-4-methyl-N-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]pentanamide
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|
||||
| Activity |
IC50 > 300000 nM
|
[21] | |||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452082; BDBM50245247
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|
||||
| Activity |
IC50 > 300000 nM
|
[21] | |||
| Compound Name |
D-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510082; BDBM50245251
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[21] | |||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-L-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501715; BDBM50272134
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|
||||
| Activity |
IC50 > 300000 nM
|
[21] | |||
| Compound Name |
Z-L-Leu-L-Phe-OMe
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452584; SCHEMBL7326037; BDBM50245249; N-benzyloxycarbonyl-L-leucyl-L-phenylalanine methyl ester; N-(Benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester; methyl (2S)-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[21] | |||
| Compound Name |
(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-methylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497810; SCHEMBL13648009; BDBM50292684
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|
||||
| Activity |
Ki = 1500000 nM
|
[19] | |||
| Compound Name |
(1R,2S)-1-(3-Fluoro-4-((2-phenylquinolin-4-yl)methoxy)benzyl)-N2-hydroxy-N1,N1-dimethylcyclopropane-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496309; SCHEMBL13648378; BDBM50292682
Click to Show/Hide
|
||||
| Activity |
Ki = 4617000 nM
|
[19] | |||
| Compound Name |
(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL495555; SCHEMBL13648000; BDBM50292683
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|
||||
| Activity |
Ki > 10000000 nM
|
[19] | |||
| Compound Name |
(1S,2R)-2-Cyano-N-hydroxy-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497769; BDBM50292680
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|
||||
| Activity |
Ki > 10000000 nM
|
[19] | |||
| Compound Name |
(1S,2R)-N-Hydroxy-2-((S)-2-(hydroxymethyl)pyrrolidine-1-carbonyl)-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL506057; SCHEMBL13648344; BDBM50292681
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[19] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9206139B2, Aggrecanase inhibitors | ||||
| REF 2 | Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. | ||||
| REF 3 | Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. | ||||
| REF 4 | The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. | ||||
| REF 5 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment ... Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. | ||||
| REF 6 | Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. | ||||
| REF 7 | Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2585-8. | ||||
| REF 8 | The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1189-93 | ||||
| REF 9 | Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13;56(11):4357-73. | ||||
| REF 10 | alpha-Biphenylsulfonylamino 2-methylpropyl phosphonates: enantioselective synthesis and selective inhibition of MMPs. Bioorg Med Chem. 2007 Jan 15;15(2):791-9. | ||||
| REF 11 | Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43. | ||||
| REF 12 | Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem. 2000 Jan 27;43(2):156-66. | ||||
| REF 13 | Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4. | ||||
| REF 14 | Sulfonate-containing thiiranes as selective gelatinase inhibitors. ACS Med Chem Lett. 2010 Dec 13;2(2):177-81. | ||||
| REF 15 | Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group. Eur J Med Chem. 2013 Nov;69:244-61. | ||||
| REF 16 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 17 | US patent application no. 8691753B2, Pseudodipeptides as MMP inhibitors | ||||
| REF 18 | Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. J Med Chem. 2008 Feb 28;51(4):835-41. | ||||
| REF 19 | Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5809-14. | ||||
| REF 20 | Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem. 2011 Oct 13;54(19):6676-90. | ||||
| REF 21 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. Eur J Med Chem. 2008 May;43(5):1008-14. | ||||
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