Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T72168 | Target Info | |||
Target Name | Mineralocorticoid receptor (MR) | ||||
Synonyms |
Nuclear receptor subfamily 3 group C member 2; Mineralocorticoid receptor; MLR; MCR; Inner ear mineralocorticoid receptor; Delta
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Target Type | Successful Target | ||||
Gene Name | NR3C2 | ||||
Biochemical Class | Nuclear hormone receptor | ||||
UniProt ID |
Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
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Compound Name |
Lecanindole D
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Investigative | Compound Info | ||
Synonyms |
Lecanindole D; CHEMBL1076438
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Activity |
IC50 > 3000000 nM
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[1] | |||
Compound Name |
(3R)-3-[1-(4-Fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2426663; BDBM50440242
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Activity |
EC50 > 5000000 nM
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[2] | |||
Compound Name |
(3S)-3-[1-(4-Fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2426662; BDBM50440243
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Activity |
EC50 > 5000000 nM
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[2] | |||
Compound Name |
Lecanindole B
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1087512; BDBM50312005
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Activity |
IC50 > 10000000 nM
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[1] |
References | Top | ||||
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REF 1 | The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. J Nat Prod. 2009 Nov;72(11):1944-8. | ||||
REF 2 | Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5442-7. |
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