Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71390 | Target Info | |||
| Target Name | Steroid 5-alpha-reductase 2 (SRD5A2) | ||||
| Synonyms |
Type 2 steroid 5alpha-reductase (5alpha-R); SRD5A2; SR type 2; 5-alpha reductase 2; 5 alpha-SR2
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| Target Type | Successful Target | ||||
| Gene Name | SRD5A2 | ||||
| Biochemical Class | CH-CH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R,3As,5aS,11aS)-3a,5a,6-trimethyl-7-oxo-N,N-di(propan-2-yl)-2,3,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-indeno[5,4-f]quinoline-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL166881; BDBM50284140
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[2-[5-(Benzhydrylcarbamoyl)benzofuran-2-yl]phenoxy]butanoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL155568; BDBM50069236; 4-{2-[5-(Benzhydryl-carbamoyl)-benzofuran-2-yl]-phenoxy}-butyric acid
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
[(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-[2-(1,2,4-triazol-1-yl)acetyl]-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735230; BDBM50135093
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
19-Nor-10-aza-5alpha-androstane-3,17-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL14575; BDBM50057289; (5aS,7aS,10aS,10bS,12aS)-7a-Methyl-tetradecahydro-indeno[4,5-c]quinolizine-2,8-dione
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-[2-(1,2,4-triazol-1-yl)acetyl]-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] cyclopropanecarboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735597
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| Activity |
IC50 = 118000 nM
|
[3] | |||
| Compound Name |
3beta-Hydroxy-21-(1H-imidazole-1-yl)pregna-5,16-diene-20-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090405; BDBM50234468; J3.584.043E
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| Activity |
IC50 = 118800 nM
|
[5] | |||
| Compound Name |
[(3S,8R,9S,10R,13S,14S)-17-(2-Imidazol-1-ylacetyl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069370; BDBM50234467
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| Activity |
IC50 = 122000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(1-Benzyl-1H-indole-5-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40831; BDBM50078267; 4-(1-Benzyl-1H-indol-5-yl)-benzoic acid
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| Activity |
IC50 = 6200000 nM
|
[6] | |||
| Compound Name |
[(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-[2-(1,2,4-triazol-1-yl)acetyl]-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] cycloheptanecarboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735695
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| Activity |
IC50 = 98000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of steroid 5alpha-reductase by "inverted", competitive inhibitors. Bioorg Med Chem Lett. 1994 Mar 24;4(6):847-51. | ||||
| REF 2 | Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group. Bioorg Med Chem Lett. 1998 Mar 17;8(6):561-6. | ||||
| REF 3 | Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5alpha-reductase and on cancer cell line SK-LU-1. Bioorg Med Chem. 2015 Dec 15;23(24):7535-42. | ||||
| REF 4 | 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29. | ||||
| REF 5 | Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5alpha-reductase 2 and with cytotoxic activity in cancer cells. Bioorg Med Chem. 2017 Mar 1;25(5):1600-1607. | ||||
| REF 6 | N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1601-6. | ||||
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