Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71230 | Target Info | |||
| Target Name | Atrial natriuretic peptide receptor A (NPR1) | ||||
| Synonyms |
NPR1; NPR-A; GC-A; Atrial natriuretic peptide A-type receptor; ANPRA; ANP-A
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| Target Type | Successful Target | ||||
| Gene Name | NPR1 | ||||
| Biochemical Class | Phosphorus-oxygen lyase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[3-[[[6-Phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083566; BDBM50262483
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Methyl-N-[4-[[2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]piperidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062309; BDBM50262484
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[4-Anilino-6-[2-imino-5-(2-methylpropyl)-4-oxoimidazolidin-1-yl]-1,3,5-triazin-2-yl]-1,2,3,3-tetramethylguanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071293; BDBM50230987
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| Activity |
EC50 = 64000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4904-4907. | ||||
| REF 2 | Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists. Bioorg Med Chem. 2017 Mar 15;25(6):1762-1769. | ||||
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