Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71192 | Target Info | |||
| Target Name | Leukotriene CysLT1 receptor (CYSLTR1) | ||||
| Synonyms |
Leukotriene D4-receptor; LTD4 receptor; HMTMF81; HG55; G-protein coupled receptor HG55; Cysteinyl leukotriene receptor 1; Cysteinyl leukotriene D4 receptor; CysLTR1; CYSLT1
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| Target Type | Successful Target | ||||
| Gene Name | CYSLTR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Oxo-2-(4-phenoxyphenyl)-4H-chromene-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213844; BDBM50323889
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-(4-cyanobutoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810333; BDBM50172352
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-oxo-3-phenoxyprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809809; BDBM50172332
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-cyclohexyloxy-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808815; BDBM50172356
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-(cyclohexylmethoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809862; BDBM50172355
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-oxo-3-pentoxyprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809152; BDBM50172354
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-oxo-3-(3-phenylpropoxy)prop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810209; BDBM50172359
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-(4-methylpentoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809106; BDBM50172353
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-oxo-3-phenylmethoxyprop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810094; BDBM50172331
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-oxo-3-(4-phenylbutoxy)prop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808722; BDBM50172357
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4,6-Dichloro-3-[(E)-3-oxo-3-(2-phenylethoxy)prop-1-enyl]-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810389; BDBM50172360
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorg Med Chem. 2010 Aug 1;18(15):5519-27. | ||||
| REF 2 | Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists. ACS Med Chem Lett. 2016 Jan 22;7(3):335-9. | ||||
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