Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70539 | Target Info | |||
| Target Name | Melanin-concentrating hormone receptor 2 (MCHR2) | ||||
| Synonyms |
SLT; MCHR-2; MCH2R; MCH2 protein; MCH-R2; MCH-2R; MCH(2) receptor; MCH receptor 2; GPRv17; GPR145; G-protein coupled receptor 145; G protein coupled receptor 145
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| Target Type | Literature-reported Target | ||||
| Gene Name | MCHR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(9-Ethylcarbazol-3-yl)spiro[indene-1,4'-piperidine]-1'-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934106; BDBM50360688
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| Activity |
IC50 = 60000 nM
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[1] | |||
| Compound Name |
(9-Ethylcarbazol-3-yl)-spiro[indene-1,4'-piperidine]-1'-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934105; BDBM50360687
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
N-(2-Diethylamino-ethyl)-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184634; SCHEMBL6107273; BDBM50153223; N-[2-(diethylamino)ethyl]-4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182554; SCHEMBL6108873; BDBM50153206; 2-methoxy-4-[(4-phenoxyphenyl)carbamoylamino]-N-(3-piperidin-1-ylpropyl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethyl-phenyl)-ureido]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187854; SCHEMBL6110058; BDBM50153203; N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(trifluoromethyl)phenyl]carbamoylamino]benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365055; SCHEMBL6108985; BDBM50153209; N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Biphenyl-4-carboxylic acid [4-(2-dimethylamino-ethylcarbamoyl)-3-methoxy-phenyl]-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL187288; SCHEMBL6108921; BDBM50153228
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Methoxy-4-[3-(3-phenoxy-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184116; SCHEMBL6109134; BDBM50153232; 2-methoxy-4-[(3-phenoxyphenyl)carbamoylamino]-N-(3-piperidin-1-ylpropyl)benzamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Methoxy-N-(3-morpholin-4-yl-propyl)-4-[3-(3-phenoxy-phenyl)-ureido]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL187093; SCHEMBL6109146; BDBM50153199; 2-methoxy-N-(3-morpholin-4-ylpropyl)-4-[(3-phenoxyphenyl)carbamoylamino]benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Biphenyl-4-carboxylic acid [4-(3-dimethylamino-propylcarbamoyl)-3-methoxy-phenyl]-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184579; SCHEMBL6110566; BDBM50153200
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):363-6. | ||||
| REF 2 | 4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5075-80. | ||||
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