Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70071 | Target Info | |||
| Target Name | Endothelin-converting enzyme (ECE) | ||||
| Synonyms |
Endothelin converting enzyme
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| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Benzenesulfonyl-heptanoic acid hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263501; 3-Benzenesulfonyl-heptanoic acid hydroxyamide; BDBM50089196
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77258; 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 78000 nM
|
[1] | ||
| Compound Name |
3-Benzenesulfinyl-heptanoic acid hydroxyamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL75433; 3-Benzenesulfinyl-heptanoic acid hydroxyamide; BDBM50089197
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
4,5-Dimethoxy-6-thiophen-3-yl-pyridine-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67142; BDBM50071307
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
4,5-Dimethoxy-6-(1-methyl-1H-pyrrol-2-yl)-pyridine-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302985; BDBM50071301
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
6-Furan-3-yl-4,5-dimethoxy-pyridine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67678; BDBM50071314
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
3-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25341; BDBM50287141
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 50000 nM
|
[3] | ||
| Compound Name |
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-methyl-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL24923; BDBM50287135
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 60000 nM
|
[3] | ||
| Compound Name |
6-Amino-2-{2-benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-hexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27111; BDBM50287143
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 60000 nM
|
[3] | ||
| Compound Name |
N-(Benzylphosphonyl)-L-Leu-L-Trp-OH
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160186
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 61000 nM
|
[4] | ||
| Compound Name |
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-methyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27273; BDBM50287131
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 80000 nM
|
[3] | ||
| Compound Name |
{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282158; BDBM50287147
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 80000 nM
|
[3] | ||
| Compound Name |
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-phenyl-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282118; BDBM50287145
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-5-guanidino-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28215; BDBM50287146
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
(S)-3-(1H-Indol-3-yl)-2-((S)-2-mercapto-4-methyl-pentanoylamino)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58812; BDBM50280863
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 100000 nM
|
[5] | ||
| Compound Name |
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-4-carbamoyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27868; BDBM50287133
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
(2R,3S)-2-[[2-Benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-hydroxybutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1794047; BDBM50366431
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28153; BDBM50287149
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235416; SCHEMBL12198648; BDBM50005641; Q27463133
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
(3S)-3-(Benzenesulfonyl)-N-hydroxyheptanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092878; BDBM50408913; ZINC13546035
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(S)-3-(1H-Indol-3-yl)-2-((R)-2-mercapto-4-methyl-pentanoylamino)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58516; BDBM50280858
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 100000 nM
|
[5] | ||
| Compound Name |
Thiorphan
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|
Investigative | Compound Info | ||
| Synonyms |
dl-thiorphan; 2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid; DL-3-Mercapto-2-benzylpropanoylglycine; CHEMBL10247; (DL-3-Mercapto-2-benzylpropanoyl)-Gly-OH; 2-(2-Benzyl-3-mercaptopropanamido)acetic acid; Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-; MFCD00058435; SR-01000076164; n-(2-benzyl-3-sulfanylpropanoyl)glycine; Prestwick_694; (+/-)-Thiorphan; ACMC-20eo1l; Prestwick0_000633; Prestwick1_000633; Prestwick2_000633; Prestwick3_000633; N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine; Lopac0_001139; BSPBio_000626; BSPBio_001543; KBioGR_000263; KBioSS_000263; MLS002153923; SCHEMBL401174; SPBio_002845; BPBio1_000690; BDBM21641; KBio2_000263; KBio2_002831; KBio2_005399; KBio3_000525; KBio3_000526; DTXSID70868412; Bio2_000263; Bio2_000743; DL-Thiorphan, >=98% (TLC); ES 52; ES-52; HMS1361N05; HMS1569P08; HMS1791N05; HMS1989N05; HMS2096P08; HMS2230G03; HMS3263D19; HMS3373F16; HMS3402N05; HMS3713P08; Tox21_501139; NSC727676; AKOS024257670; CCG-205213; LP01139; NSC-727676; SDCCGSBI-0051106.P003; IDI1_034013; SMP2_000064; DL-Thiorphan - CAS 76721-89-6; N-(2-Benzyl-3-mercaptopropanoyl)glycine; NCGC00016033-02; NCGC00016033-03; NCGC00016033-04; NCGC00016033-05; NCGC00016033-06; NCGC00016033-11; NCGC00094405-01; NCGC00094405-02; NCGC00094405-03; NCGC00094405-04; NCGC00261824-01; SMR001233267; (DL-3-Mercapto-2-benzylpropionyl)-Gly-OH; EU-0101139; FT-0675192; 2-(2-benzyl-3-sulfanylpropanamido)acetic acid; C01619; T 6031; (+/-)-N-(3-Mercapto-2-benzylpropionyl)glycine; N-alpha-[(})-3-Thio-2-benzylpropanoyl]glycine; Q7784695; SR-01000076164-1; SR-01000076164-5; 2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid; BRD-A56012032-001-06-4; Racecadotril active metabolite; Acetorphan active metabolite
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
(3R)-3-(Benzenesulfonyl)-N-hydroxyheptanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1788203; BDBM50369525; ZINC13546036
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[[Ethoxy(hydroxy)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160202
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 109000 nM
|
[4] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417224
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[Ethoxy(hydroxy)phosphoryl]oxy-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160196
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
2-[[(1S)-1-Carboxy-2-(1H-indol-3-yl)ethyl]carbamoyl]-4-methylpentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61085
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(2S)-2-[[2-(Hydroxymethyl)-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL294571
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[Hydroxy(propyl)phosphoryl]oxy-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160176
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[[Hydroxy(propyl)phosphoryl]methyl]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160194
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[[Ethoxy(hydroxy)phosphoryl]methyl]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160190
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
(2S)-3-(1H-Indol-3-yl)-2-[[4-methyl-2-(2-sulfanylethyl)pentanoyl]amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58064
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
3-(Naphthalene-2-sulfonyl)-heptanoic acid hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78001; BDBM50089199
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|
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| Activity | Endothelin-converting enzyme 1 |
IC50 = 450000 nM
|
[1] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. | ||||
| REF 2 | Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1). Bioorg Med Chem Lett. 1998 Aug 18;8(16):2117-22. | ||||
| REF 3 | Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitors. Bioorg Med Chem Lett. 1996 Jun 18;6(12):1323-6. | ||||
| REF 4 | Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potency. J Med Chem. 1993 Jan 8;36(1):173-6. | ||||
| REF 5 | Thiol and hydroxamic acid containing inhibitors of endothelin converting enzyme. Bioorg Med Chem Lett. 1993 Oct;3(10):1953-8. | ||||
| REF 6 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis. Eur J Med Chem. 2014 May 22;79:184-93. | ||||
| REF 7 | Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11. Bioorg Med Chem Lett. 1997 Apr 22;7(8):1059-64. | ||||
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