Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69991 | Target Info | |||
| Target Name | Wee1-like protein kinase (WEE1) | ||||
| Synonyms |
Wee1A kinase; WEE1hu
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| Target Type | Clinical trial Target | ||||
| Gene Name | WEE1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
9-Hydroxy-4-phenyl-1H-furo[3,4-c]carbazole-1,3-(6H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209894; BDBM50192397
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-2,6-dimethyl-4-phenylpyrrolo[3,4-c]carbazole-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378921; BDBM50192391; 2,6-dimethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
8-Methyl-2-phenylamino-6-(2,3,6-trichloro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360225; BDBM50164116
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(2,6-Dichloro-3-methyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360689; BDBM50164157
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
6-(2,6-Dichloro-3-methoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180401; BDBM50164119
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(2,6-Dichloro-3,5-dimethoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361574; BDBM50164133
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(2,6-Dichloro-4-methoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360672; BDBM50164137
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
10-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379264; BDBM50192347
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5,8-Dimethyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL359732; BDBM50164147
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(2-Chloro-6-trifluoromethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360698; BDBM50164118
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1,9-Dihydroxy-4-phenyl-1,6-dihydropyrrolo[3,4-c]carbazol-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL383920; SCHEMBL5828952; BDBM50192421
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-4-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215706; BDBM50192378
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
6-(4-Methoxy-2,6-dimethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180448; BDBM50164127
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[2,4-Dichloro-3-(8-methyl-7-oxo-2-phenylamino-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-phenyl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180740; BDBM50164129
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(2,6-Dimethoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180673; BDBM50164132
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
9-Hydroxy-4-[3-(trifluoromethyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211627; BDBM50192408
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(Biphenyl-4-yl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484985; BDBM50279443
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| Activity |
IC50 = 50118.72 nM
|
[3] | |||
| Compound Name |
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098682; BDBM50242512
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163772; BDBM50395892
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|
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| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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|
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| Activity |
Ki > 1000000 nM
|
[6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modific... J Med Chem. 2006 Aug 10;49(16):4896-911. | ||||
| REF 2 | Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1931-5. | ||||
| REF 3 | Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem. 2009 Apr;44(4):1383-95. | ||||
| REF 4 | Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. | ||||
| REF 5 | Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. | ||||
| REF 6 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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