Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69619 | Target Info | |||
| Target Name | Membrane copper amine oxidase (AOC3) | ||||
| Synonyms |
Vascular adhesion protein-1; Vascular adhesion protein 1; VAP1; VAP-1; Semicarbazide-sensitive amine oxidase; SSAO; Membrane primary amine oxidase; HPAO; Copper amine oxidase
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | AOC3 | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 39 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benzimidazole
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
BENZIMIDAZOLE; 51-17-2; 1H-Benzimidazole; 1H-Benzo[d]imidazole; 1,3-Benzodiazole; Benzoimidazole; o-Benzimidazole; 3-Azaindole; Benziminazole; Benzoglyoxaline; Azindole; 1,3-Diazaindene; 1H-Benzoimidazole; N,N'-Methenyl-o-phenylenediamine; NSC 759; Benzimidazol; 1H-1,3-benzodiazole; BZI; UNII-E24GX49LD8; CCRIS 5967; Benzimidazole, 98%; CHEBI:41275; HSDB 2797; EINECS 200-081-4; BRN 0109682; AI3-03737; E24GX49LD8; HYZJCKYKOHLVJF-UHFFFAOYSA-N; DSSTox_CID_4573; DSSTox_RID_77454; DSSTox_GSID_24573; F3366-5347; CAS-51-17-2; bezimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R*,2S*)-2-Hydrazino-1,2-diphenylethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766382; BDBM50341611
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
6-Ethoxy-5-[(E)-hydroxyiminomethyl]-1,3-dimethylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1444067; CHEMBL3679666; BDBM102367
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
3-Cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557160
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
5-[(E)-Hydroxyiminomethyl]-1,3-dimethyl-6-propylsulfanylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2208796; CHEMBL3679670; BDBM102372; US8536210, 21
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[3] | |||
| Compound Name |
1H-Indol-2-amine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-AMINOINDOLE HYDROCHLORIDE; 1H-INDOL-2-AMINE HCL; 1H-indol-2-amine;hydrochloride; CHEMBL2392114; 2-aminoindole HCl; 1H-Indol-2-amine, monohydrochloride; SCHEMBL5435898; DTXSID80958131; BCP27951; ANW-66386; MFCD06798215; AKOS015898503; ACN-052441; SB18479; AC-24549; AS-41181; DB-069463; FT-0611251; X2016; 1H-Indol-2-amine--hydrogen chloride (1/1); 946A700
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[1] | |||
| Compound Name |
3-Cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537628
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[4] | |||
| Compound Name |
(E)-4-Phenoxybut-2-en-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029530; SCHEMBL3983710; BDBM50384092
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[5] | |||
| Compound Name |
(E)-1-[4-(Nitrosomethyl)-1,3-benzodioxol-5-yl]but-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3679663; BDBM102359; US8536210, 8
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[3] | |||
| Compound Name |
5-Methyl-1H-benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Methyl-1H-benzo[d]imidazol-2-amine; 5-Methyl-2-aminobenzimidazole; 1H-Benzimidazol-2-amine, 5-methyl-; 6-methyl-1H-benzimidazol-2-amine; 5-METHYL-1H-BENZO[D]IMIDAZOL-2-AMINE; CHEMBL2392116; 5-Methyl-1H-benzoimidazol-2-ylamine; 5-methyl-1H-1,3-benzodiazol-2-amine; 2-amino-6-methyl-benzimidazole; CCRIS 4356; 2-amino-5-methylbenzimidazole; AI3-60093; NSC10547; UNII-44V7C5WTS8; SCHEMBL129665; 2-amino-5 -methylbenzimidazole; 44V7C5WTS8; 5-methylbenzimidazole-2-ylamine; SCHEMBL19451945; CTK5B6360; DTXSID20212022; ALBB-012403; 1H-Benzimidazol-2-amine,6-methyl-; ANW-56817; BDBM50435708; MFCD01658297; NSC-10547; SBB051992; ZINC63060535; 6-Methyl-1H-Benzoimidazol-2-Ylamine; AKOS005173592; AKOS011972709; AB09657; MCULE-3452309484; 6-methyl-1H-1,3-benzodiazol-2-amine; KS-00001A56; AM804156; SC-51045; TS-01926; DB-058099; BB 0240994; FT-0683580; 5-Methyl-1H-benzimidazol-2-amine, AldrichCPR; Y-7732; 285M683; Z2197092708
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-{4-[2-(4-Aminophenyl)ethyl]thiazol-2-yl}acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326856; N-(4-(2-(4-aminophenyl)ethyl)-1,3-thiazol-2-yl)acetamide; N-(4-[2-(4-Aminophenyl)ethyl]-1,3-thiazol-2-yl)acetamide; N-(4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-2-yl}acetamide; N-[4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-2-yl]acetamide; N-{4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-2-yl)acetamide; N-{4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-2-yl}acetamide; SCHEMBL3934166; BDBM50427027
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-Aminoimidazole sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Imidazol-2-Amine Sulfate; Imidazol-2-ylamine sulphate; 1H-Imidazol-2-amine;sulfuric acid; 1H-Imidazol-2-amine, sulfate (1:1); CHEMBL2392115; EINECS 255-791-7; Bis(2-amino-1H-imidazole) sulphate; 2-aminoimidazolesulfate; Amino imidazole sulfate; ACMC-1AKJK; 2-aminoimidazole sulphate; 2-amino imidazole sulfate; 2-amino-imidazole sulfate; 2-Aminoimidazole monosulfate; SCHEMBL10845; C3H7N3O4S; KSC236I9L; 1H-imidazole-2-amine sulfate; 1H-imidazol-2-amine H2SO4; 1H-Imidazol-2-amine xsulfate; 1H-imidazol-2-ylamine sulfate; CTK1D6495; KS-00000IVW; DTXSID10932469; 2-aminoimidazole hydrogen sulphate; ACT02001; EINECS 215-918-9; ANW-20909; MFCD00050811; NSC101169; AKOS000121163; AKOS032949854; MCULE-4937045321; NSC-101169; SB11997; SB11998; AK-25424; BR-25424; SC-01137; SC-19892; AB0070898; Z4665; M-5120; F0001-0516; Sulfuric acid--1,3-dihydro-2H-imidazol-2-imine (1/1)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Methyl-1H-benzo[d]imidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-methyl-1H-benzimidazol-2-amine; 1H-Benzimidazol-2-amine, 4-methyl- (9CI); 1H-Benzimidazol-2-amine, 4-methyl-; CHEMBL2392117; 1h-benzimidazol-2-amine,4-methyl-; 2-amino-4-methylbenzimidazole; SCHEMBL727228; AMBZ0067; CTK0E4727; DTXSID20565666; KS-00001A5U; 4-Methyl-1H-benzoimidazole-2-amine; 8797AA; ANW-69985; BDBM50435710; MFCD13188622; ZINC34410850; AKOS011973099; AKOS024016072; AB15833; EBD2212058; AM803323; AS-39673; CS-0036161; Y-0799
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-N-[[3-(4-morpholin-4-ylphenyl)phenyl]methyl]-N-propan-2-ylacetamide;(2R,3R)-2,3-dihydroxybutanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943540; BDBM50205272
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDROCHLORIDE; 1H-Benzimidazole-2-methanamine, dihydrochloride; (1H-1,3-benzodiazol-2-yl)methanamine dihydrochloride; 2-aminomethylbenzimidazole dihydrochloride; 2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO-; c-(1h-benzoimidazol-2-yl)-methylamine dihydrochloride; benzimidazol-2-ylmethylamine, chloride, chloride; (1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE 2HCL; 1H-1,3-benzodiazol-2-ylmethanamine dihydrochloride; SCHEMBL244831; CHEMBL3143911; KS-00000MGI; MFCD00012677; SBB003357; AKOS015898452; CS-W005436; MCULE-7619260609; aminomethyl-benzimidazole dihydrochloride; AK-39566; BR-39566; SC-52714; SY018489; TS-03147; 2-aminomethyl-benzimidazole dihydrochloride; AB0025752; DB-072725; 2-(amino methyl)benzimidazole dihydrochloride; 2-(aminomethyl)benzimidazole, dihydrochloride; AM20060685; FT-0608725; ST50307530; W7267; (1H-Benzo[d]imidazol-2-yl)methanamine DiHCl; 1H-Benzimidazole-2-methanamine dihydroChloride; ethyl3-amino-3-[(aminocarbonyl)amino]butyrate; 1-(Benzimidazol-2-yl)methanamine hydrochloride; 1H-benzimidazol-2-ylmethanamine;dihydrochloride; S-3675; 2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO-CHL; 2-(Aminomethyl)benzimidazole dihydrochloride, 98%; 1-(1H-benzimidazol-2-yl)methanamine dihydrochloride; F1994-0021; Z1262246193; (1h-benzo[d]imidazol-2-yl)methanamine dihydrochloride salt
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Aminobenzothiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzo[d]thiazol-2-amine; 2-Benzothiazolamine; 1,3-Benzothiazol-2-amine; Benzothiazol-2-ylamine; Benzothiazole-2-ylamine; 2-Amino-benzothiazole; 2-Aminobenzthiazole; 2-Iminobenzothiazoline; o-Aminobenzothiazole; Benzothiazole, 2-amino-; benzothiazolamine; 2-Benzothiazolylamine; 2(3H)-Benzothiazolimine; USAF XR-27; 2-amino-1,3-benzothiazol; NSC 4670; USAF EK-3941; UNII-08K5TLY3EQ; 2-Amino-1,3-benzothiazole; MFCD00005785; 2-Aminobenzothiazole, 97%; 08K5TLY3EQ; CHEMBL329785; 2-aminobenzothiazol; HSDB 2741; EINECS 205-268-4; AI3-52249; aminobenzothiazole; iminobenzothiazoline; benzothiazolyl-amine; 2-amino benzthiazole; Benzothiazol-2-ylamin; PubChem13382; 2-Aminobenzothiazole, 6; ACMC-1C8TV; DSSTox_CID_4467; 2-amino-1,3-benzthiazole; Cambridge id 5108799; DSSTox_RID_77412; 1,3-benzothiazol-2-ylamine; DSSTox_GSID_24467; SCHEMBL75245; KSC178I9N; MLS002415693; BIDD:GT0339; 1,3-Benzothiazol-2-amine #; SCHEMBL4511001; WLN: T56 BN DSJ CZ; DTXSID1024467; 1,3-benzothiazol-2(3H)-imine; CTK0H8496; NSC4670; HMS1577K04; HMS3039J05; BCP26554; NSC-4670; STR00404; ZINC6476824; Tox21_200818; ANW-20195; BBL009589; BDBM50335100; CL4537; SBB004071; STL139201; STL186134; AKOS000119893; AKOS016368231; CS-W018140; FS-3142; MCULE-2707577485; SB18592; KS-00000A08; NCGC00091895-01; NCGC00091895-02; NCGC00258372-01; AK-41354; BP-21206; BR-41354; SC-64617; SMR001370883; DB-027802; A0277; AM20060503; BB 0240617; ST50308085; Y6822; M-6117; 97305-EP2272832A1; 97305-EP2305688A1; AE-848/01007013; W-108245; W-204451; Q27236407; Z56912586; F1386-0409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-Phenylguanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenylguanidine; N-Phenylguanidine; 2-phenylguanidine; GUANIDINE, PHENYL-; alpha-Phenylguanidine; N-Phenyl-guanidine; 1N-amino(immino)methylaniline; CHEMBL14047; EINECS 217-898-7; phenyl guanidine; Monophenylguanidin; N-phenyl guanidine; N-Phenylguanidine #; Guanidine, N-phenyl-; Phenylguanidine mononitrate; SCHEMBL256023; BDBM93095; DTXSID70173836; ALBB-019781; ZINC4276940; BDBM50053620; MFCD00092876; AKOS000266439; MCULE-1696687582; guanidine, N-phenyl-, carbonate(1:1); AM803464; AS-39432; SC-43561; L-4044; J-007368; Q27464460; F2158-0402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Phenethyl-1H-imidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2392119; 5-Phenethyl-1H-imidazol-2-ylamine; SCHEMBL224617; BDBM50435709; ZINC96271637; 5-(2-phenylethyl)-1H-imidazol-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R,3R)-2,3-Dihydroxybutanedioic acid;2-(dimethylamino)-N-methyl-N-[[3-(4-morpholin-4-ylphenyl)phenyl]methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985575; BDBM50205324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-(Acetylamino)-4-[4-(3,3-dimethylguanidino)phenethyl]thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326863; BDBM50427020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-Methylaminobenzylamine dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-Phenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204384
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R,3R)-2,3-Dihydroxybutanedioic acid;N-methyl-2-(methylamino)-N-[[3-(4-morpholin-4-ylphenyl)phenyl]methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933487; BDBM50205323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-Phenyl-1H-imidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-phenyl-1H-imidazol-2-amine; 2-amino-5-phenylimidazole; CHEMBL1649757; 4-phenylimidazole-2-ylamine; 1H-Imidazol-2-amine, 4-phenyl-; 4-phenyl-2-aminoimidazole; SCHEMBL395101; 4-phenyl-1H-imidazol-2-ylamine; CTK8B6100; 5-Phenyl-1H-imidazol-2-ylamine; DTXSID20508432; ALBB-033735; KS-00000P0X; ANW-52538; BBL022358; BDBM50435705; MFCD03308784; SBB019172; STK695164; ZINC12404725; AKOS005606358; AKOS016000200; AB41897; ACN-001173; CS-W022422; AK-64962; DS-15691; ST096987; 4-phenyl-1H-imidazol-2-amine, AldrichCPR; T9694; 775P402; Z2327226361
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Aminomethyl)-N,N-dicyclopentylpyridin-3-amine;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559376
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
2-Aminoquinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinazolin-2-amine; 2-Quinazolinamine; Quinazolin-2-ylamine; 2-amino quinazoline; Quinazoline, 2-amino-; CHEMBL187951; MFCD00956186; quinazolinimine; aminoquinazoline; iminoquinazoline; amino-quinazoline; Quinazoline-2-ylnitrogen; SCHEMBL41506; 2-amino quinazoline, AldrichCPR; CTK0H3769; DTXSID70333973; KS-00000L0Y; ZINC5519265; ANW-51830; BDBM50154585; AKOS006274005; AB07784; CS-W009159; AK-24681; AM803311; BR-24681; DS-10687; SC-49360; SY109190; AB0022753; FT-0648432; W3677; A-2609; A18289; 180909-EP2269993A1; 197136-EP2272517A1; 687A510
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Z)-4-Phenoxybut-2-en-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029529; BDBM50384091
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(2-Aminoethyl)-N-methyl-3-(4-morpholin-4-ylphenyl)benzamide;(2R,3R)-2,3-dihydroxybutanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925681; BDBM50205329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-[(1-Methylethyl)amino]-4-aminomethylpyridine dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537175
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
2-Ethylaminobenzylamine dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Phenyl-4,5-dihydro-1h-imidazol-2-amine hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543123; Cambridge id 5140737; SCHEMBL4392392; AKOS016374070; MCULE-2949711613; Z56767233; 1-Phenyl-4, 5-dihydro-1H-imidazol-2-amine hydrobromide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-1-methylbenzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-Methyl-1H-benzimidazol-2-amine; 1-methyl-1H-benzo[d]imidazol-2-amine; 1H-Benzimidazol-2-amine, 1-methyl-; 1-methylbenzimidazol-2-amine; 1-METHYL-2-AMINOBENZIMIDAZOLE; 1-methyl-1H-1,3-benzodiazol-2-amine; 1-Methyl-1H-benzoimidazol-2-ylamine; 1H-Benzimidazol-2-amine,1-methyl-; 1-methylbenzimidazole-2-ylamine; 2-Amino-1-methylbenzimidazole, 99+%; CCRIS 4355; BRN 0608298; 2-Amino-1-Methyl-Benzimidazole; MFCD00142855; Oprea1_009900; 1-methyl-2-benzimidazolamine; BIDD:GT0052; SCHEMBL149707; CHEMBL1232570; BDBM14319; CTK4D1161; DTXSID10167330; Benzimidazole, 2-amino-1-methyl-; ZINC163724; 2-amino-1-methyl-1h-benzimidazole; 1-Methyl-2-amino-1H-benzimidazole; ALBB-009345; KS-000019OT; STR05341; 1-Methyl-1H-benzimidazol-2-ylamine; 8227AA; ANW-72215; BBL013458; SBB004092; STK096886; 1-Methyl-1H-benzimidazol-2-amine #; 2-Amino-1-methylbenzimidazole, 95%; 1-methyl-1 h-benzoimidazol-2-ylamine; AKOS000275856; ACN-048949; MCULE-6570566756; VI10098; AM803285; ST079160; AB0073959; DB-043519; BB 0241020; CS-0038976; FT-0633713; W-6539; 1-methyl-1,3-dihydro-benzoimidazol-2-ylideneamine; A810361; J-009915; BRD-K20617646-001-01-0; Q27460053; F0266-0062
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-N,2-dimethyl-N-[[3-(4-morpholin-4-ylphenyl)phenyl]methyl]propanamide;(2R,3R)-2,3-dihydroxybutanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942461; BDBM50205334
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-(Aminomethyl)-N-cyclopropylpyridin-3-amine;hydrate;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537174
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Methoxy-2-methyl-3-(nitrosomethyl)benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3679660; BDBM102352; US8536210, 1
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[3] | |||
| Compound Name |
5-[(E)-Hydroxyiminomethyl]-1,3-dimethyl-6-phenylsulfanylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2209686; CHEMBL3679673; BDBM102375
Click to Show/Hide
|
||||
| Activity |
IC50 = 106000 nM
|
[3] | |||
| Compound Name |
6-Ethylsulfanyl-5-[(E)-hydroxyiminomethyl]-1,3-dimethylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2210488; CHEMBL3679672; BDBM102374; US8536210, 23
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[3] | |||
| Compound Name |
6-Ethylsulfanyl-5-[(E)-methoxyiminomethyl]-1,3-dimethylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2213797; CHEMBL3679674; BDBM102376; US8536210, 25
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[3] | |||
| Compound Name |
4-(Nitrosomethyl)-5-[2-(nitrosomethyl)phenyl]-1,3-benzodioxole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3679665; BDBM102363; US8536210, 12
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[(E)-Hydroxyiminomethyl]-2-methyl-5-piperidin-1-ylpyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2188990; CHEMBL3679676; BDBM102380; US8536210, 29
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[3] | |||
| Compound Name |
4-[(E)-Hydroxyiminomethyl]-2-[(4-methoxyphenyl)methyl]-5-morpholin-4-ylpyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2186059; SCHEMBL2551079; CHEMBL3679677; BDBM102383; US8536210, 32
Click to Show/Hide
|
||||
| Activity |
IC50 = 263000 nM
|
[3] | |||
| Compound Name |
4-(Aminomethyl)-3-N-methyl-3-N,5-N-dipropylpyridine-3,5-diamine;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537406
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment. Bioorg Med Chem. 2013 Jul 1;21(13):3873-81. | ||||
| REF 2 | Novel hydrazine molecules as tools to understand the flexibility of vascular adhesion protein-1 ligand-binding site: toward more selective inhibitors. J Med Chem. 2011 Apr 14;54(7):2143-54. | ||||
| REF 3 | US patent application no. 8536210B2, Compounds for inhibiting semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) and uses thereof for treatment and prevention of diseases | ||||
| REF 4 | Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases. J Med Chem. 2005 Feb 10;48(3):664-70. | ||||
| REF 5 | The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3935-40. | ||||
| REF 6 | Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema. Bioorg Med Chem. 2013 Mar 1;21(5):1219-33. | ||||
| REF 7 | Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors. Bioorg Med Chem. 2017 Jan 1;25(1):187-201. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.