Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T69506 | Target Info | |||
| Target Name | Orphan nuclear receptor NR1I3 (NR1I3) | ||||
| Synonyms |
Orphan nuclear receptor MB67; Orphan nuclear receptor CAR; Nuclear receptor subfamily 1 group I member 3; Nuclear receptor CAR; Constitutive androstane receptor; Constitutive active response; Constitutive activator of retinoid response; CAR
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| Target Type | Successful Target | ||||
| Gene Name | NR1I3 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(5-{3-[4-(2-Hydroxyethyl)piperazinyl]propanoyl}(10H,11H-dibenzo[b,f]azepin-3-yl))(methylethoxy)carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1625328; ChemDiv1_024290; Oprea1_792951; Oprea1_840768; SCHEMBL19225041; HMS656A02; BDBM50146366; STL320871; ZINC19369681; AKOS000548650; ST50258383; AB00638866-06
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| Activity |
IC50 ~ 70000 nM
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[1] | |||
| Compound Name |
Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1497437; 3-Carbethoxyamino-5-aminoacetyl-10,11-dihydro-5H-dibenz(b,f)azepine; ChemDiv1_024422; Ethyl (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)carbamate; MLS001206543; SCHEMBL9732095; HMS656G02; DTXSID40157845; HMS2836K12; ZINC303643; BDBM50146372; AKOS000548785; ethyl N-[11-(2-aminoacetyl)-5,6-dihydrobenzo[b][1]benzazepin-2-yl]carbamate; MCULE-3799987588; NCGC00245320-01; SMR000517203; ST50258388; N-[5-(2-aminoacetyl)(10H,11H-dibenzo[b,f]azepin-3-yl)]ethoxycarboxamide
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| Activity |
IC50 ~ 70000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor. Eur J Med Chem. 2016 Jan 27;108:505-528. | ||||
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