Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69485 | Target Info | |||
| Target Name | Orexin receptor type 2 (HCRTR2) | ||||
| Synonyms |
Ox2r; Ox2-R; Ox-2-R; Orexin-2 receptor; Hypocretin receptor type 2; HFGANP
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|
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| Target Type | Successful Target | ||||
| Gene Name | HCRTR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
G-N-H-A-A-G-I-L-T-L
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430345; BDBM50140015
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
S-G-N-H-A-A-G-I-L-T-M
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214619; BDBM50139980
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
N-H-A-A-G-I-L-T-L
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL280472; BDBM50139967
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
R-S-G-P-P-G-L-Q-G-R-L-Q-R-L-L-Q
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL409188; BDBM50139991
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(3S)-4-[[(2R)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-Amino-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2R)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-[[(2S)-1-[(2S)-4-methyl-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370375
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
L-L-H-G-A-G-N-H-A-A-G-I-L-T-L
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439167; BDBM50139987
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
A-G-N-H-A-A-G-I-L-T-L
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384047; BDBM50140007
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
H-A-A-G-I-L-T-L
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429205; BDBM50140000
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
R-S-G-P-P-G-L-Q-G-R-L-Q-R
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412250; BDBM50140027
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(3S)-4-[[(2R)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-Amino-1-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-[[(2S)-1-[(2S)-4-methyl-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370351
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
R-S-G-P-P-G-L-Q-G-R
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386724; BDBM50139963
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
L-L-Q-A-S-G-N-H-A-A-G-I-L-T-M
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384249; BDBM50139978
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity studies of orexin a and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands. J Med Chem. 2004 Feb 26;47(5):1153-60. | ||||
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