Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69128 | Target Info | |||
| Target Name | Proto-oncogene c-Ros (ROS1) | ||||
| Synonyms |
c-Ros receptor tyrosine kinase; Receptor tyrosine kinase c-ros oncogene 1; ROS; Proto-oncogene tyrosine-protein kinase ROS; Proto-oncogene c-Ros-1; MCF3
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| Target Type | Successful Target | ||||
| Gene Name | ROS1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[4-[6-(3-Hydroxypropylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)pyrazol-1-yl]acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397285; BDBM50062382
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| Activity |
IC50 = 50900 nM
|
[1] | |||
| Compound Name |
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(3-morpholin-4-ylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397293; BDBM50062370
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| Activity |
IC50 = 55500 nM
|
[1] | |||
| Compound Name |
2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(2-morpholin-4-ylethylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397287; BDBM50062369
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| Activity |
IC50 = 57600 nM
|
[1] | |||
| Compound Name |
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(3-hydroxypropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397290; BDBM50062365
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| Activity |
IC50 = 73400 nM
|
[1] | |||
| Compound Name |
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(2-morpholin-4-ylethylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397292; BDBM50062371
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| Activity |
IC50 = 90900 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors. Eur J Med Chem. 2015 Jan 27;90:195-208. | ||||
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