Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69085 | Target Info | |||
| Target Name | Transcription factor AP-1 (JUN) | ||||
| Synonyms |
V-jun avian sarcoma virus 17 oncogene homolog; Proto-oncogene c-jun; P39; C-jun proto-oncogene; Activator protein-1; Activator protein 1; AP1; AP-1 transcription factor
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| Target Type | Discontinued Target | ||||
| Gene Name | JUN | ||||
| Biochemical Class | Basic leucine zipper bZIP | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[(4R,10S,13S,16S,19S,22S,25S,31R)-31-Acetamido-25-(3-amino-3-oxopropyl)-4-carbamoyl-19-(carboxymethyl)-13-methyl-16,22-bis(2-methylpropyl)-6,9,12,15,18,21,24,27,30-nonaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacont-10-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3222140; BDBM50044554
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| Activity |
IC50 = 64000 nM
|
[1] | |||
| Compound Name |
(Z)-3-[(1S,4As,7S,7aS)-7-hydroxy-4-methoxycarbonyl-5-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,7a-dihydro-1H-cyclopenta[c]pyran-7-carbonyl]oxy-2-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3341961; BDBM50044558
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| Activity |
IC50 = 69600 nM
|
[1] | |||
| Compound Name |
2-Anthracenecarboxylic acid, 9,10-dihydro-3,8-dihydroxy-9,10-dioxo-1-propyl-
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Investigative | Compound Info | ||
| Synonyms |
K-1115A; UNII-5H24KBZ64W; 5H24KBZ64W; CHEMBL3341957; 3,8-dihydroxy-9,10-dioxo-1-propylanthracene-2-carboxylic acid; MEGxm0_000263; SCHEMBL16431884; ACon0_000664; ACon1_001399; BDBM50044555; K-115A; K1115 A; NCGC00180547-01; BRD-K62840109-001-01-7; Q27262173; 1-propyl-2-carboxy-3,8-dihydroxy-9,10-anthracenedione
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(4-Chloro-phenyl)-2-(2-methylamino-4-phenyl-thiazol-5-yl)-3H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242795; SCHEMBL4391595; BDBM50326122; 3-(4-chlorophenyl)-2-[2-(methylamino)-4-phenyl-1,3-thiazol-5-yl]quinazolin-4-one
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| Activity |
IC50 > 500000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem. 2014 Aug 28;57(16):6930-48. | ||||
| REF 2 | Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: inhibitors of multi-pathways involve in cancer. Eur J Med Chem. 2010 Sep;45(9):3558-63. | ||||
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