Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67849 | Target Info | |||
| Target Name | PI3-kinase delta (PIK3CD) | ||||
| Synonyms |
PtdIns-3-kinase subunit p110-delta; PtdIns-3-kinase subunit delta; Phosphoinositide 3-kinase delta; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PI3Kdelta; PI3K-delta; PI3-kinase subunit delta; PI3-kinase p110 subunit delta; P110delta
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| Target Type | Successful Target | ||||
| Gene Name | PIK3CD | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 84 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sorafenib
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Approved | Compound Info | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
PMID28870136-Compound-48
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Patented | Compound Info | ||
| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
PMID28870136-Compound-52
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Patented | Compound Info | ||
| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(R)-2-(3-Benzylmorpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477787; BDBM50262406
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2,11-Dichloro-6,7-dihydrobenzimidazolo[1,2-d][1,4]benzoxazepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401248; BDBM50064855
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
11-Fluoro-2-methyl-6,7-dihydrobenzimidazolo[1,2-d][1,4]benzoxazepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401243; BDBM50064859
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-Acetyl-N-[5-(4-morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)pyrimidin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109136; BDBM50495508
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(S)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL469059; BDBM50262359
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-Bromo-11-fluoro-6,7-dihydrobenzimidazolo[1,2-d][1,4]benzoxazepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401245; BDBM50064856
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[5-[3-(2-Hydroxyethylsulfamoyl)-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785694; BDBM50160073
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
3-[2-(4-Methoxyphenyl)ethynyl]-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322235; SCHEMBL13000215; BDBM50427461
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(R)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512470; BDBM50262358
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(5-Morpholin-4-yl-7-oxothieno[3,2-b]pyran-3-yl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322231; SCHEMBL13000075; BDBM50427465
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[2-(3-Methoxyphenyl)pyrido[3,2-d]pyrimidin-4-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109124; BDBM50495503
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Bromo-11-chloro-6,7-dihydrobenzimidazolo[1,2-d][1,4]benzoxazepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401249; BDBM50064788
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(2-Pyridin-3-ylpyrido[3,2-d]pyrimidin-4-yl)morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109130; BDBM50495496
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Morpholino-3-(pyridin-3-yl)-7H-thieno[3,2-b]pyran-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322240; SCHEMBL2821601; BDBM50427479; 5-morpholin-4-yl-3-pyridin-3-ylthieno[3,2-b]pyran-7-one
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-Methyl-11-(trifluoromethyl)-6,7-dihydrobenzimidazolo[1,2-d][1,4]benzoxazepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401259; BDBM50064861
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(4-Thiomorpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109117; BDBM50495506
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2,11-Dimethyl-6,7-dihydrobenzimidazolo[1,2-d][1,4]benzoxazepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403813; BDBM50064860
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[4-(4,4-Difluoropiperidin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109120; BDBM50495511
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[2-(4-Methoxyphenyl)pyrido[3,2-d]pyrimidin-4-yl]morpholine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109125; BDBM50495493
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[4-(4-Methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109119; BDBM50495515
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[4-(1,1-Dioxo-1,4-thiazinan-4-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109118; BDBM50495513
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Morpholin-4-ylthieno[3,2-b]pyran-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322246; SCHEMBL13000098; BDBM50427490
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(Furan-3-yl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322227; SCHEMBL13000150; BDBM50427468
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
6-Pyrimidin-2-yl-1,3-benzothiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600702; BDBM50106927
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| Activity |
IC50 = 50118.72 nM
|
[8] | |||
| Compound Name |
2-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944796; BDBM50204098
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
11-(4-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589323; BDBM50094954
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| Activity |
IC50 = 56890 nM
|
[10] | |||
| Compound Name |
5-(2-Amino-1,3-benzothiazol-6-yl)-N,N-dimethylpyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600697; BDBM50107271
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| Activity |
IC50 = 63095.73 nM
|
[8] | |||
| Compound Name |
6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600686; BDBM50107262
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| Activity |
IC50 = 63095.73 nM
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[8] | |||
| Compound Name |
6-Oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
UNII-9V1XHG6QRM; 9V1XHG6QRM; 2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile; CHEMBL58782; 1,2-dihydro-2-oxo-5-(4-pyridinyl)-nicotinonitrile; 6-Odbcn; Inamrinone nitrile [USP]; SCHEMBL7281879; DTXSID70159918; (N-(1,6-Dihydro-6-oxo-(3,4'-bipyridine)-5-carbonitrile); ZINC155538; BDBM50024966; Inamrinone related compound C [USP]; AKOS022645570; MCULE-1980235207; 5-cyano[3,4'-bipyridin]-6(1H)-one; Inamrinone related compound C [USP-RS]; 5-cyano-[3,4'-bipyridin]-6(1H)-one; ST50999862; 2-oxo-5-(4-pyridyl)hydropyridine-3-carbonitrile; 1,6-Dihydro-6-oxo-3,4'-bipyridine-5-carbonitrile; 6-Oxo-1,6-dihydro-(3,4'-bipyridine)-5-carbonitrile; 6-Oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile; [3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro-6-oxo-, hydrobromide (1:1)
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| Activity |
IC50 = 65700 nM
|
[11] | |||
| Compound Name |
11-(3-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589322; BDBM50094953
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| Activity |
IC50 = 71350 nM
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[10] | |||
| Compound Name |
3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242665
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| Activity |
IC50 = 72000 nM
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[1] | |||
| Compound Name |
trans-4-[[[6-[1-(Cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-cyclohexanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
AZ044; CHEMBL3600785; BDBM50107257; SB19683
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| Activity |
IC50 ~ 79432.82 nM
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[8] | |||
| Compound Name |
6-Pyridin-2-yl-1,3-benzothiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600700; BDBM50107274
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| Activity |
IC50 = 79432.82 nM
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[8] | |||
| Compound Name |
N-[6-(3-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064480; SCHEMBL3098972; BDBM50389393
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| Activity |
IC50 ~ 79432.82 nM
|
[12] | |||
| Compound Name |
3-(3-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241357; 3-(3-aminophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 82000 nM
|
[1] | |||
| Compound Name |
2-(Pyridin-4-yl)benzo[d]oxazol-5-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645096; BDBM50333212; ZINC16431343; AKOS003232867; 2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-OL
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| Activity |
IC50 ~ 83300 nM
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[11] | |||
| Compound Name |
2-Pyridin-4-yl-benzooxazol-5-ylamine
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Investigative | Compound Info | ||
| Synonyms |
2-(pyridin-4-yl)-1,3-benzoxazol-5-amine; 2-(pyridin-4-yl)benzo[d]oxazol-5-amine; 2-pyridin-4-yl-1,3-benzoxazol-5-amine; CHEMBL1645099; 2-(4-pyridyl)benzoxazole-5-ylamine; Oprea1_262137; CBDivE_012963; SCHEMBL4076162; CTK4H3354; DTXSID90352904; ZINC155043; ALBB-006224; 2-(4-Pyridinyl)-5-benzoxazolamine; 1121AE; BBL012052; BDBM50333214; MFCD00448006; SBB007305; STK026134; 2-Pyridin-4-ylbenzooxazol-5-yl amine; AKOS000108388; CCG-109259; MCULE-8999136327; VS-03182; 5-amino-2-(pyridine-4-yl)benzo[d]oxazole; 5-amino-2-(pyridine-4-yl) benzo[d]oxazole; BB 0245215; EU-0041953; H2652; ST50024827; SR-01000465976; SR-01000465976-1
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| Activity |
IC50 ~ 83300 nM
|
[11] | |||
| Compound Name |
3-(2-Acetamido-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064486; SCHEMBL3101636; BDBM50389398
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| Activity |
IC50 ~ 100000 nM
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[12] | |||
| Compound Name |
8-Chloro-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064569; BDBM50389429
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(6-Isoquinolin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064494; SCHEMBL3104880; BDBM50389404
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N,N-Dimethyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064505; SCHEMBL3091951; BDBM50389388
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1320032; CHEMBL1241358; 3-(4-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1231371; 1-tert-butyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; NA-PP2; SCHEMBL1964558; 1-tert-butyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine; BDBM50345704; NCGC00167637-01; Q27458432; 1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(tert-butyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3)
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(6-Pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064495; SCHEMBL3087621; BDBM50389405
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[6-(1-Methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064497; BDBM50389425
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-((1H-Indazol-3-yl)ethynyl)aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631888; SCHEMBL12269728; BDBM50333031; ZINC66263421
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenol; CHEMBL1241355; J-002258; (6Z)-6-(4-amino-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-ylidene)cyclohexa-2,4-dien-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Methyl-3-(4-phenylmethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL130425; CHEMBL1242206
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600781; BDBM50107248
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
N-[6-[4-(Methylsulfamoyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064488; BDBM50389423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[6-(3-Phenylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064491; BDBM50389424
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(1-Isopropyl-4-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241942
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[6-(2,4-Dimethyl-1,3-thiazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064496; BDBM50389390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-(2-Amino-7-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064572; BDBM50389421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(6-Chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)-N-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL577499; ZINC4487914; BDBM50302393; STK241617; AKOS000458470; MCULE-6231566477; 3-(6-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)-N-phenylpropanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(1,2,3,4-Tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241440; 3-(1,2,3,4-tetrahydronaphthalen-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(6-Pyrimidin-5-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064493; SCHEMBL3081151; BDBM50389403
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-Methyl-N-[6-(3-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064503; BDBM50389410
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-Methyl-3-(3-phenylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242849
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[7-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064566; BDBM50389416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[5-[(3-Methoxyphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methylphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018409; BDBM50381605
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242292; 3-[3-[(2,6-dichlorophenyl)methoxy]phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-[[(5,6-Dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]methyl]-2-furancarboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL579219; MLS000098595; HMS1735N05; HMS2472F22; ZINC3495367; BDBM50302390; AKOS016644433; MCULE-7517981492; SMR000065125; SR-01000074855; SR-01000074855-1; Q27210712; Z20229806
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
8-Methyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-1,3-benzoxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL244672; BDBM50401468
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241863
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242205
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[6-(4-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064487; BDBM50389399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-((1H-Indazol-3-yl)ethynyl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631895; SCHEMBL12269751; BDBM50333024; ZINC66263695
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5065122; CHEMBL1242850; 3-(4-phenylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(5-Methylsulfonylpyridin-3-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064568; BDBM50389418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[6-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064506; BDBM50389411
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[5-[(3-Chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018263; BDBM50381607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
13-Morpholin-4-yl-11-(morpholin-4-ylmethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589373; BDBM50094944
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[10] | |||
| Compound Name |
13-Morpholin-4-yl-11-(1-morpholin-4-ylethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589374; BDBM50094945
Click to Show/Hide
|
||||
| Activity |
IC50 = 154780 nM
|
[10] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600782; BDBM50107254
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[8] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600783; BDBM50107255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[8] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600784; BDBM50107256
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[8] | |||
| Compound Name |
4-(2-Amino-1,3-benzothiazol-6-yl)-1-(2-methoxyethoxy)pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600780; BDBM50107244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[8] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,4a,5,6-hexahydronaphtho[2,1-b][1]benzofuran-8-yl)boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959396; SCHEMBL15278021; BDBM196114; US9206201, AZ
Click to Show/Hide
|
||||
| Activity |
IC50 = 303000 nM
|
[17] | |||
| Compound Name |
5-(2-Amino-5-fluoro-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205763; SCHEMBL3258676; BDBM50401150
Click to Show/Hide
|
||||
| Activity |
IC50 = 7943282.35 nM
|
[18] | |||
| Compound Name |
CID 44621448
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205767; SCHEMBL3222900; BDBM50401153; 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2,2,2-trifluoroethyl)pyridine-3-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 7943282.35 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N,N-diethylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205771; SCHEMBL3226533; BDBM50401144
Click to Show/Hide
|
||||
| Activity |
IC50 = 12589254.12 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-benzylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205770; SCHEMBL3225926; BDBM50401145
Click to Show/Hide
|
||||
| Activity |
IC50 = 19952623.15 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-methylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205774; SCHEMBL3234736; BDBM50401143
Click to Show/Hide
|
||||
| Activity |
IC50 = 25118864.32 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-phenylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205769; SCHEMBL3232284; BDBM50401142
Click to Show/Hide
|
||||
| Activity |
IC50 = 25118864.32 nM
|
[18] | |||
| Compound Name |
7-[5-(2,2-Dimethylazetidin-1-yl)sulfonylpyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205772; BDBM50401146
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205773; SCHEMBL3228404; BDBM50401149
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propan-2-ylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205765; SCHEMBL3226438; BDBM50401148
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
CID 44621449
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205768; SCHEMBL13536557; BDBM50401147
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
7-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203312; SCHEMBL3262808; BDBM50401141
Click to Show/Hide
|
||||
| Activity |
IC50 = 39810717.06 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205766; SCHEMBL3226712; BDBM50401152; ZINC95562659
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118723.36 nM
|
[18] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 2 | Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55. | ||||
| REF 3 | 4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4316-20. | ||||
| REF 4 | 6,7-Dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives as selective inhibitors of PI3Kalpha. Bioorg Med Chem. 2015 Mar 15;23(6):1231-40. | ||||
| REF 5 | Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors. J Med Chem. 2014 Feb 13;57(3):613-31. | ||||
| REF 6 | Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III. J Med Chem. 2016 Mar 10;59(5):1830-9. | ||||
| REF 7 | Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors. J Med Chem. 2013 Mar 14;56(5):1922-39. | ||||
| REF 8 | Discovery of potent, selective small molecule inhibitors of alpha-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIalpha). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93. | ||||
| REF 9 | 6-Aryl substituted 4-(4-cyanomethyl) phenylamino quinazolines as a new class of isoform-selective PI3K-alpha inhibitors. Eur J Med Chem. 2016 Oct 21;122:731-743. | ||||
| REF 10 | Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kalpha inhibitors. Eur J Med Chem. 2015 Jun 24;99:1-13. | ||||
| REF 11 | Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening. Bioorg Med Chem Lett. 2011 Jan 15;21(2):829-35. | ||||
| REF 12 | SAR studies around a series of triazolopyridines as potent and selective PI3K inhibitors. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5257-63. | ||||
| REF 13 | Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway. J Med Chem. 2010 Dec 9;53(23):8368-75. | ||||
| REF 14 | Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. | ||||
| REF 15 | Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents. Bioorg Med Chem. 2012 May 15;20(10):3359-67. | ||||
| REF 16 | Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines. Eur J Med Chem. 2012 Nov;57:85-101. | ||||
| REF 17 | US patent application no. 9206201B2, Boronic acid bearing liphagane compounds as inhibitors of P13K-alpha and/or beta | ||||
| REF 18 | Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4613-8. | ||||
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