Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67730 | Target Info | |||
| Target Name | Delta-tryptase (TPSD1) | ||||
| Synonyms |
TPSD1; Mast cell mMCP-7-like; HmMCP-3-like tryptase III; Delta tryptase
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TPSD1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[5-[4-[2-[4-[2-[4-[5-(Diaminomethylideneamino)pentanoyl]piperazin-1-yl]-2-oxoethoxy]phenoxy]acetyl]piperazin-1-yl]-5-oxopentyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109660; BDBM50217311
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[1] | |||
| Compound Name |
1beta,5beta-Bis[4-(benzylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43463; BDBM50093140
Click to Show/Hide
|
||||
| Activity |
Ki = 101000 nM
|
[2] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1beta,5beta-Bis[4-[2-[1-(1-iminoethyl)-4-piperidinyl]ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77326; BDBM50093201
Click to Show/Hide
|
||||
| Activity |
Ki = 255000 nM
|
[2] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-imidazol-1-ylbutanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76967; BDBM50093150
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[2] | |||
| Compound Name |
1beta,5beta-Bis[4-[1-(1-iminoethyl)-4-piperidinylmethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309395; BDBM50093174
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3285-90. | ||||
| REF 2 | Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2361-6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.