Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67103 | Target Info | |||
| Target Name | Integrin alpha-V (ITGAV) | ||||
| Synonyms |
Vitronectin receptor subunit alpha; Vitronectin receptor alpha subunit; Vitronectin receptor; VTNR; VNRA; MSK8; CD51 antigen; CD51
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | ITGAV | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 13 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(R)-3-(2-Phenylacetamido)-2-(2,4,6-trimethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559677; BDBM50296622
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Amino-2-(2,4,6-trimethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553901; BDBM50296628
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Acetamido-2-benzamidopropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557519; BDBM50296617
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Acetamido-2-(phenoxycarbonylamino)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557520; BDBM50296615
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Acetamido-2-(phenylmethylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540219; BDBM50296618
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-(Tert-butoxycarbonylamino)-2-(2,4,6-trimethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551266; BDBM50296626
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Acetamido-2-(2,6-dichlorobenzamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557449; BDBM50296616
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-(Benzylamino)-2-(2,4,6-trimethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551468; BDBM50296621
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Acetamido-2-(tert-butoxycarbonylamino)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549990; SCHEMBL22637154; BDBM50296614
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-(Methylsulfonamido)-2-(2,4,6-trimethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562271; BDBM50296624
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-Acetamido-2-(N,2,4,6-tetramethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549991; BDBM50296613
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-3-(Methoxycarbonylamino)-2-(2,4,6-trimethylphenylsulfonamido)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561994; BDBM50296625
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[(2S,5R,8S,11S)-5-Benzyl-11-[3-(diaminomethylideneamino)propyl]-8-[[4-[[[4-[2-[(E)-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylideneamino]oxyethylamino]-4-oxobutanoyl]amino]methyl]phenyl]methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590715; BDBM50308725
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel inhibitors of the alphavbeta3 integrin--lead identification strategy. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4832-5. | ||||
| REF 2 | Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation. Bioorg Med Chem. 2010 Jan 1;18(1):64-72. | ||||
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