Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65879 | Target Info | |||
| Target Name | Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | ||||
| Synonyms |
Transcription factor 16; TCF16; TCF-16; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IkappaB kinase A; IkBKA; IKK1; IKK-alpha; IKK-A; I-kappa-B kinase alpha; I-kappa-B kinase 1; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CHUK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 78 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
IMD-0354
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
IMD-2560; IMD-2560); I-kappaB kinase beta inhibitor (dermatological, atopic dermatitis/acne), Institute of Medicinal MolecularDesign; I-kappaB kinase beta inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD; IKK-beta inhibitor (dermatological, atopic dermatitis/acne), IMMD; IL-6 release inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
PMID19364658C33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL8163; BDBM50259563
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
PMID23374866C31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4idv; GTPL8174; BDBM50429614; 13V
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-{[2-(3-Thienyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL481248; BDBM50259638
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(5-Fluoro-6-Iodo-1-Methyl-1h-Indol-3-Yl)-4-(7-Methoxy-1-Benzofuran-3-Yl)-1h-Pyrrole-2,5-Dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523435; SCHEMBL3142971; BDBM50267521; Q27466736; 3-(5-Fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxybenzofuran-3-yl)pyrrole-2,5-dione; 3-(5-fluoro-6-iodo-1-methylindol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)pyrrole-2,5-dione; 3-(5-Fluoro-6-iodo-1-methyl-1H-indol-3-yl )-4-(7-methoxy benzofuran-3-yl)-pyrrole-2,5-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466496; SCHEMBL4365652; BDBM50259376; DB07234; Q27096459; 3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281957; SCHEMBL6621670; BDBM50126732
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-(7-(4-((1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087650; SCHEMBL1015620; BDBM50311985
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468125; 3-{[2-(2-Fluorophenyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione; SCHEMBL4371574; BDBM50259601
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-{[2-(2-Furyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519113; SCHEMBL4366875; BDBM50259637; 3-[[2-(furan-2-yl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-Tert-Butyl-N-[2-Methyl-3-(6-{[4-(Morpholin-4-Ylcarbonyl)phenyl]amino}-7h-Purin-2-Yl)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263640; BDBM50012060; Q27453164; 4-t-butyl-N-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide; 4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl]amino}-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467079; SCHEMBL4379540; BDBM50259532; 2-[[3,4-dioxo-2-(pyridin-4-ylamino)cyclobuten-1-yl]amino]-2-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-(4-Bromophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(4-bromophenyl)-5-methyl-1H-pyrazol-3-amine; 5-Amino-4-(4-bromophenyl)-3-methylpyrazole; 4-(4-bromophenyl)-5-methyl-2H-pyrazol-3-amine; CHEMBL4294454; SCHEMBL13310491; CTK5I7189; CTK8F6718; DTXSID80589429; ZINC8701292; KM3347; AKOS009142305; AS-65477; CS-0119878; V9624; 4-(4-bromophenyl)-5-methyl-2h-pyrazol-3-ylamine; 5-Amino-4-(4-bromophenyl)-3-methylpyrazole, 96%; Z274574824
Click to Show/Hide
|
||||
| Activity |
IC50 = 89700 nM
|
[3] | |||
| Compound Name |
Chembl4286561
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(3-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(3-Chlorophenyl)-5-methyl-1H-pyrazol-3-amine; 1H-Pyrazol-3-amine, 4-(3-chlorophenyl)-5-methyl-; 4-(3-chlorophenyl)-3-methylpyrazole-5-ylamine; 3-Amino-4-(3-chlorophenyl)-5-methyl pyrazole; CHEMBL4292952; CTK2B7901; DTXSID20490520; ALBB-032828; ZINC8701428; MFCD09438994; SBB082624; AKOS000302222; AKOS008124417; AKOS022304209; MCULE-3974962278; BB 0260654; ST50532394; EN300-88760; Y-5281; Z1262237268; 4-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-amine(SALTDATA; 4-(3-CHLOROPHENYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4281464
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280454
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AKOS012196576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4292701
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4284888
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4281692; CTK6C0953; CTK8F5130; ALBB-006919; MFCD12027287; STK504195; ZINC32919530; AKOS000264664; 3-Methyl-4-(m-tolyl)-1H-pyrazol-5-amine; 5-methyl-4-(3-methylphenyl)-1H-pyrazol-3-amine; Z2680629344
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283909
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL15742048; ZINC41286240; AKOS011268000; 4-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-Methoxy-12-methyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
imidazothienopyrazine, 18; CHEMBL249516; SCHEMBL14431814; BDBM25945
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(diethylamino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223204; BDBM50325370; 4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(diethylamino)ethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4284120
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4294749
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4279494
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4288356
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4288275
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280373
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 3-Methyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine; SCHEMBL7888487; CHEMBL4293369; CTK6C3912; CTK8F5132; KS-00001RBI; DTXSID00382373; ZINC3883286; 0710AF; KM2296; MFCD03791147; SBB099416; AKOS005069280; MCULE-7916739921; 10T-0382; 3-methyl-4-[3-(trifluoromethyl)phenyl]pyrazole-5-ylamine; 3-Methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-(1-(4-Chlorobenzyl)piperidin-3-yl)-2-ureido-5,7-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681984; BDBM50338236
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Chembl4284415
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223203; BDBM50325369; 4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(dimethylamino)ethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4286012
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4284828
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-phenyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Methyl-4-phenyl-2H-pyrazol-3-ylamine; 5-amino-3-methyl-4-phenylpyrazole; 5-methyl-4-phenyl-1H-pyrazol-3-amine; 3-Amino-5-Methyl-4-Phenylpyrazole; 5-methyl-4-phenyl-2H-pyrazol-3-amine; UNII-OC0W48DG01; OC0W48DG01; 1H-Pyrazol-3-amine,5-methyl-4-phenyl-; 1H-Pyrazol-5-amine,3-methyl-4-phenyl-; 3-methyl-4-phenylpyrazole-5-ylamine; Pyrazole, 5-amino-3-methyl-4-phenyl-; 1H-Pyrazol-3-amine, 5-methyl-4-phenyl-; Maybridge3_005336; Oprea1_166909; MLS000718547; SCHEMBL544723; Pyrazole, 3(OR 5)-amino-5(OR 3)-methyl-4-phenyl-; CHEMBL1609052; CTK4G7923; CTK5B1468; DTXSID80975823; HMS1446C12; HMS2678A07; ALBB-006621; KS-00003KC6; ZINC8743937; BBL007578; CCG-48710; KM0404; MFCD00831955; SBB010561; STK161389; AKOS000265012; AKOS015898914; FS-1252; MCULE-5899288516; SB21940; IDI1_016723; 3-Amino-5-methyl-4-phenyl-1H-pyrazole; 3-Methyl-4-phenyl-1H-pyrazole-5-amine; 5-Methyl-4-phenyl-1H-pyrazol-3-ylamine; SMR000290815; ST037469; AB0131798; DB-053614; A5753; BB 0219097; FT-0640686; V6864; EN300-41461; AB00583018-02; SR-01000530901; 5-Methyl-4-phenyl-1,2-dihydro-3H-pyrazol-3-imine; SR-01000530901-1; SR-01000530901-2; 5-Methyl-4-phenyl-2H-pyrazol-3-ylamine, AldrichCPR; Q27285561; F0912-0735
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4292088
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4294725
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4287493
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-(1-(2-Fluoro-4-methoxybenzyl)piperidin-3-yl)-2-ureido-5,7-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681990; BDBM50338240
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372345; BDBM50175691; 2-([4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino)benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4295066
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4290916
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4291313
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280665
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4284710
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL21586252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-(1-(2,4-Difluorobenzyl)piperidin-3-yl)-2-ureido-5,7-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681986; BDBM50338238
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(4-Chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamine; 4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-amine; 4-(4-chlorophenyl)-3-methylpyrazole-5-ylamine; Cambridge id 5679811; Oprea1_349134; MLS000719160; SCHEMBL1248139; CHEMBL1885200; CTK6G9598; CTK8F5367; DTXSID10341799; HMS2712J14; HMS3535D16; ALBB-007578; ZINC4660540; 7274AD; BBL012526; MFCD00737209; SBB011182; STK234817; AKOS000270520; AKOS022304211; CCG-200054; MCULE-2044086228; SMR000291428; ST064643; VS-03371; AB0169146; BB 0219143; Y-7651; AB00093218-01; Pyrazol-5-amine, 4-(4-chlorophenyl)-3-methyl-; 3-Methyl-4-(4-chlorophenyl)-1H-pyrazol-5-amine; 4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-ylamine; 4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-ylamine #; F2130-0219; 4-(4-Chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4290266
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4288230
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(3-Bromophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(3-bromophenyl)-5-methyl-1H-pyrazol-3-amine; CHEMBL4285123; ZINC37504468; AKOS009590873; AKOS022316431; MCULE-7105794193; NE43735; Y2624; EN300-75549; Z1255523429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4291690
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280067
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-(1-Benzylpiperidin-3-yl)-2-(carbamoylamino)-4,5-dihydrothieno[2,3-e]indazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681981; BDBM50338235; (+/-)-7-(1-benzylpiperidin-3-yl)-2-ureido-5,7-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Chembl4286341
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4291646
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AKOS011267413
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-methyl-4-(4-methylphenyl)pyrazole-5-ylamine; SCHEMBL842957; CHEMBL4286140; SBB079697; ZINC12880096; AKOS000687244; MCULE-6721632026; 3-Methyl-4-p-tolyl-1H-pyrazol-5-amine; BB 0219346; ST50530128; J3.614.174C; 5-methyl-4-(4-methylphenyl)-1H-pyrazol-3-amine; 3-Methyl-4-(4-methylphenyl)-1H-pyrazol-5-a mine; 4-(4-Methylphenyl)-3-methyl-1H-pyrazole-5-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2H-1,3-Benzodioxol-5-yl)-5-methyl-1H-pyrazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4289568; SCHEMBL15020886; ZINC36936208; AKOS022774009; MCULE-8451113259; NE45413; 4-(1,3-benzodioxol-5-yl)-5-methyl-1H-pyrazol-3-amine; Z1278581691; 3-Methyl-4-(3,4-methylenedioxyphenyl)-1H-pyrazol-5-amine; 4-(2H-1,3-benzodioxol-5-yl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4278086
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283501
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4287264
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283080
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[1-(dimethylamino)propan-2-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223207; BDBM50325371; 4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(1-(dimethylamino)propan-2-yl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4287399
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283832
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4279585
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4277586
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4287256
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4282760
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4281003
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4293673
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4177097
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50277996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4283047
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 4-Hydroxy- N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-B cascade. Medchemcomm. 2017 Aug 25;8(9):1850-1855. | ||||
| REF 2 | Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. | ||||
| REF 3 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 4 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 5 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 6 | From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem. 2009 Apr 9;52(7):1853-63. | ||||
| REF 7 | Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. J Med Chem. 2003 Apr 10;46(8):1337-49. | ||||
| REF 8 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 9 | Discovery of highly potent and selective type I B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6571-4. | ||||
| REF 10 | Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases. Bioorg Med Chem Lett. 2014 May 1;24(9):2206-11. | ||||
| REF 11 | Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4284-9. | ||||
| REF 12 | Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5113-8 | ||||
| REF 13 | Novel dihydrothieno[2,3-e]indazole derivatives as I B kinase inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1758-62 | ||||
| REF 14 | Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.