Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65019 | Target Info | |||
| Target Name | Matrix metalloproteinase-14 (MMP-14) | ||||
| Synonyms |
Membrane-type-1 matrix metalloproteinase; Membrane-type matrix metalloproteinase 1; MTMMP1; MT1MMP; MT1-MMP; MT-MMP 1; MMP-X1
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MMP14 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 81 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1607004-34-1
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|
Patented | Compound Info | ||
| Synonyms |
ADAMTS Inhibitor C7; SCHEMBL15692551; CHEMBL3980860; BDBM194644; 1607004-34-1; US9206139, 3
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
US9206139, 4
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|
Patented | Compound Info | ||
| Synonyms |
CHEMBL3955404; SCHEMBL15692527; BDBM194645; US9206139, 4
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Methotrexate gamma-L-phenylalaninehydroxamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396296; methotrexate gamma-L-phenylalaninehydroxamic acid
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| Activity |
IC50 = 70000 nM
|
[3] | |||
| Compound Name |
Folate gamma-L-phenylalaninehydroxamic acid
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|
Investigative | Compound Info | ||
| Activity |
IC50 = 80000 nM
|
[3] | |||
| Compound Name |
N1,N3-bis(3-methoxybenzyl)isophthalamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605201; N1,N3-bis(3-methoxybenzyl)isophthalamide; SCHEMBL5332068
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Benzyl N-[(4R)-4-[[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770688
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|
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
2-(4-Chlorophenoxy)-N-{[(4r)-4-Methyl-2,5-Dioxoimidazolidin-4-Yl]methyl}acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358151; 4wk7; BDBM50033809; Q27454023; 3PQ
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenylamino)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269994; SCHEMBL4738506; BDBM50329265; (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-2-(4-Fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760324; SCHEMBL3436885; BDBM50340754; (2S)-2-[(4-fluoro-3,5-dimethylphenyl)methyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012837; BDBM50379534
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2010824; BDBM50379535
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-2-{4'-[(5-Chloro-4-isopropoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194430; SCHEMBL3609695; BDBM50173231
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|
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
(2s)-6-[(4-Fluorobenzyl)amino]-2-[(2r)-2-(4-Fluorophenyl)-2-Methoxyethyl]-N-Hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760318; SCHEMBL639348; BDBM50340758; Q27451207; (s)-6-(4-fluorobenzylamino)-2-((r)-2-(4-fluorophenyl)-2-methoxyethyl)-n-hydroxyhexanamide; (2S)-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(2S)-2-[(2R)-2-(4-Fluorophenyl)-2-methoxyethyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012838; BDBM50379533
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012836; BDBM50379536
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760322; BDBM50340768
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(4-(2-Oxo-2H-chromen-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927183; ZINC2957866; BDBM50359721; AKOS024602290; MCULE-4659831116; F0920-6501
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|
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| Activity |
IC50 = 51000 nM
|
[9] | |||
| Compound Name |
5-Pyridin-3-yl-1H-indole-2-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939869; SCHEMBL15642502; BDBM50361627; DB-124065; ethyl 5-pyridin-3-yl-1H-indole-2-carboxylate; 5-(pyridin-3-yl)-1H-indole-2-carboxylic acid ethyl ester
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| Activity |
IC50 = 51000 nM
|
[10] | |||
| Compound Name |
(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4-dihydroxy-5-methoxybenzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556277; BDBM50296240
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|
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| Activity |
IC50 = 52000 nM
|
[11] | |||
| Compound Name |
(2E)-3-(N-Hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401445; BDBM50213419
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|
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| Activity |
IC50 = 53100 nM
|
[12] | |||
| Compound Name |
3-[({2-[4-({[(4s)-4-Methyl-2,5-Dioxoimidazolidin-4-Yl]methyl}sulfonyl)piperazin-1-Yl]pyrimidin-5-Yl}oxy)methyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409696; 4jpa; AZ6; BDBM50437765; Q27458135
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|
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| Activity |
IC50 = 53584 nM
|
[13] | |||
| Compound Name |
2-[2-[(E)-(5-Oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927185; BDBM50359723
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|
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
(R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-YL)hexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
UK 370106; UK-370106; CHEMBL250266; SCHEMBL6449140; C35H44N2O5; ZINC3916209; 1503AB; BDBM50227718; AKOS016004936; HY-107639; CS-0029038; J-014984
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|
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| Activity |
IC50 = 66900 nM
|
[14] | |||
| Compound Name |
3-{1-[(Methoxy-phenyl-methyl)-carbamoyl]-2,2-dimethyl-propylcarbamoyl}-6-(2-methyl-biphenyl-4-yl)-hexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115460; BDBM50131663
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|
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| Activity |
IC50 = 66900 nM
|
[15] | |||
| Compound Name |
Benzyl N-[(4R)-4-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431027; BDBM50441213
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|
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| Activity |
IC50 = 68000 nM
|
[5] | |||
| Compound Name |
[(Naphthalen-1-ylamino)-phosphonomethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440429; SCHEMBL8333842; BDBM50442507
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| Activity |
IC50 = 69000 nM
|
[16] | |||
| Compound Name |
N-Hydroxy-2-[[4-[(4-phenylphenyl)methoxy]phenyl]sulfonylamino]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431032; BDBM50441225
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| Activity |
IC50 = 72000 nM
|
[17] | |||
| Compound Name |
Cruzain-IN-1
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Investigative | Compound Info | ||
| Synonyms |
ML092; CHEMBL567341; MMV676881; 6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile; 6-(3,5-difluoroanilino)-9-ethylpurine-2-carbonitrile; 6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile; 6-[(3,5-difluorophenyl)amino]-9-ethyl-9H-purine-2-carbonitrile; Cruzain-IN-1ML092; Cruzain-IN-1;ML-092; ML092 Cruzain-IN-1; MLS002471782; HMS2203P24; HMS3332L09; BCP29960; BDBM50303420; NCGC00181918-01; NCGC00181918-02; BS-14613; HY-10836; ML092;ML 092;ML-092; SMR001395197; CS-0002855; S0722; Q27164166
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|
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| Activity |
IC50 = 72443.6 nM
|
[18] | |||
| Compound Name |
[[4-(4-Chlorophenoxy)anilino]-phosphonomethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440431; BDBM50442509
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|
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| Activity |
IC50 = 76000 nM
|
[16] | |||
| Compound Name |
Chembl4160618
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278364
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| Activity |
IC50 = 76300 nM
|
[19] | |||
| Compound Name |
2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL585376; BDBM50299069
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| Activity |
IC50 = 77000 nM
|
[20] | |||
| Compound Name |
N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380404
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| Activity |
Ki = 85000 nM
|
[21] | |||
| Compound Name |
N-[[(4S)-4-(1-Methylimidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-5-(trifluoromethyl)-1-benzofuran-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358158; BDBM50033808
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| Activity |
IC50 = 86000 nM
|
[6] | |||
| Compound Name |
Chembl4164016
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278389
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| Activity |
IC50 = 87100 nM
|
[19] | |||
| Compound Name |
(5S)-5-[[4-[5-[(3-Ethyl-1,2-oxazol-5-yl)methoxy]pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409675; BDBM50437761
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|
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| Activity |
IC50 = 98907 nM
|
[13] | |||
| Compound Name |
(5S)-5-[[4-[5-[(4-Fluorophenyl)methoxy]pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409695; BDBM50437766
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|
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| Activity |
IC50 ~ 99999 nM
|
[13] | |||
| Compound Name |
(5S)-5-Methyl-5-[[4-[5-[(3-methyl-1,2-oxazol-5-yl)methoxy]pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]imidazolidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409674; BDBM50437763
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
[Phosphono-[4-(trifluoromethyl)anilino]methyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440440; BDBM50442517
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(P-Tolylamino)methylenediphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440439; SCHEMBL11570312; BDBM50442518; ZINC96286211; p-tolylaminomethylenedi-phosphonic acid; (4-Methylphenyl)aminomethylenebisphosphonic acid; [(4-methylanilino)-phosphonomethyl]phosphonic acid
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(3R)-6-Cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL226852; SCHEMBL6599390; BDBM50216790
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|
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-Chloro-N-{[(4s)-4-(1-Methyl-1h-Imidazol-2-Yl)-2,5-Dioxoimidazolidin-4-Yl]methyl}-1-Benzofuran-2-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358156; 4wki; BDBM50033806; Q27454018; 3PW
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
[(3-Fluoroanilino)-phosphonomethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440436; BDBM50442513
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
[(2,4-Dichloroanilino)-phosphono-methyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL191613; BDBM50165966; 2,4-Dichloroanilinomethylenebisphosphonic acid; 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID; [(2,4-dichloro-phenyl)aminomethylene]-1,1-bisphosphonate; [(2,4-Dichloro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(2,4-dichlorophenyl)amino]methylene]bis-
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
MLS000755676; SMR000337350; 4-(4-methylphenoxy)-N-[(pyridin-4-yl)methyl]benzamide; 4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide; CHEMBL1427458; BDBM46421; cid_4358655; HMS2618P15; KS-00003O5G; ZINC4054502; AKOS005107358; MCULE-5269053313; MS-1279; 4-(4-methylphenoxy)-N-(4-pyridylmethyl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-butyl-1-[(2S)-1-(4-hydroxyphenyl)-3-[(2S)-2-[[(6R)-6-(naphthalen-2-ylmethyl)-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]piperazine-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593549; BDBM50104623
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
[(4-Cyanoanilino)-phosphonomethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440437; BDBM50442516
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|
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1940296; BDBM50419619
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| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
2-(Benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL234737; BDBM50241254; N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid
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| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]carbonyl}-1,2,4-oxadiazol-5-yl)hexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL439012; SCHEMBL6178395; BDBM50216817
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
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| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Schembl21751149
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235912; BDBM50104619
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-[(4-hydroxyphenyl)methyl]-1-[(2R)-1-[(2S)-2-[[(6R)-6-[(4-hydroxyphenyl)methyl]-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-naphthalen-2-ylpropan-2-yl]piperazine-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593550; BDBM50104622
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(3-Bromophenylamino)Methylenediphosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370662; BDBM50173799; [(3-Bromophenyl)amino]methylenebisphosphonic acid; [(3-bromoanilino)-phosphono-methyl]phosphonic acid; (3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate; [(3-Bromo-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-bromophenyl)amino]methylene]bis-
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-[(2S)-2-[[(6R)-6-benzyl-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-cyclohexylpropan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593552; BDBM50104618
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
[Anilino(phosphono)methyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440580; SCHEMBL7796889; N-phenylaminomethanediphosphonic acid; BDBM50442523; Phenylaminomethylenebisphosphonic acid; (PHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
[(4-Hydroxyanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440438; SCHEMBL4088119; BDBM50442515
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,5-dihydroxy-4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556692; BDBM50296241
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
CID 78426619
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235911; SCHEMBL20271444; BDBM50104621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-cyclohexyl-3-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593551; BDBM50104620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-Chloroanilinomethylenebisphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440579; BDBM50442521; ZINC59245747; N-(p-chlorphenyl)-aminomethanediphosphonic acid; (4-CHLOROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
[(4-Fluoro-3-nitroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440434; BDBM50442511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylidenemethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318252; SCHEMBL3882021; BDBM50146472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(4s)-3-{[4-(4-Cyano-2-Methylphenyl)piperazin-1-Yl]sulfonyl}-N-Hydroxy-1,3-Thiazolidine-4-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770935; Q27462716
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
[(3-Nitroanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450938; SCHEMBL13458525; BDBM50173796; (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID; [(3-Nitro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-nitrophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[[4-[2-(2,5-Dimethylpyridin-4-yl)ethyl]piperidin-1-yl]sulfonylmethyl]oxan-4-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784338; BDBM50345513
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD-503; CHEMBL409536; SCHEMBL5957461; PD503; BDBM50234334; ZINC29133346; DB08561; Q27097766
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
[Phosphono-[3-(trifluoromethyl)anilino]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440435; BDBM50442514
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389020; SCHEMBL5411951; BDBM50216802; (R)-6-cyclohexyl-N-hydroxy-3-(3-(methylsulfonamidomethyl)-1,2,4-oxadiazol-5-yl)hexanamide; (3R)-6-cyclohexyl-N-hydroxy-3-[3-(methanesulfonamidomethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
[(4-Fluoroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440581; BDBM50442522
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]-4-(benzyloxycarbonylamino)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431026; BDBM50441214
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[17] | |||
| Compound Name |
Chembl4163839
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278363
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[19] | |||
| Compound Name |
Chembl4162521
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278366
Click to Show/Hide
|
||||
| Activity |
IC50 = 111350 nM
|
[19] | |||
| Compound Name |
N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431021; BDBM50441215
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[17] | |||
| Compound Name |
N-Hydroxy-2-[4-(8-quinolylmethoxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431019; BDBM50441220
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[17] | |||
| Compound Name |
N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576762; BDBM50299066
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[20] | |||
| Compound Name |
N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonyl(methyl)amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431022; BDBM50441218
Click to Show/Hide
|
||||
| Activity |
IC50 = 123000 nM
|
[17] | |||
| Compound Name |
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567134; MLS002471787; SCHEMBL3353019; HMS2198O14; BDBM50303441; NCGC00182110-01; NCGC00182110-02; SMR001395200; Q27165373; 9-(3,5-difluorophenyl)-6-(ethylamino)purine-2-carbonitrile; 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 134896.29 nM
|
[18] | |||
| Compound Name |
(2Z,NE)-N-benzylidene-4-(3,4-dimethoxyphenyl)-2-(phenylimino)thiazol-3(2H)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927187; BDBM50359725; STL264510; AKOS002238584; ST50113618; F0807-0342; (2Z)-4-(3,4-dimethoxyphenyl)-2-(phenylimino)-N-[(E)-phenylmethylidene]-1,3-thiazol-3(2H)-amine; 4-[3-((1E)-2-phenyl-1-azavinyl)-2-(phenylazamethylene)(1,3-thiazolin-4-yl)]-1, 2-dimethoxybenzene
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[9] | |||
| Compound Name |
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-methoxy-phenylsulfanyl)-propyl]-phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324891; BDBM50138685
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[30] | |||
| Compound Name |
N-Hydroxy-2-[4-[3-bromo-5-(p-anisyl)benzyloxy]phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431024; BDBM50441217
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[17] | |||
| Compound Name |
N-Hydroxy-N''-[(S)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355727; BDBM50112001
Click to Show/Hide
|
||||
| Activity |
Ki = 180000 nM
|
[31] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 29 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380397; BDBM50433870
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[21] | |||
| Compound Name |
5-Pyridin-4-yl-1H-indole-2-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939870; SCHEMBL15642864; BDBM50361628; DB-124067; ethyl 5-pyridin-4-yl-1H-indole-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 225000 nM
|
[10] | |||
| Compound Name |
3,2-Diguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,2'-diguanidinoneamine; CHEMBL215074; BDBM12005; Neamine guanidinylated deriv. 21
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[32] | |||
| Compound Name |
Neamine guanidinylated deriv. 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215715; BDBM12012; 1,3,2,6-Tetraguanidino-5,6,3,4-tetramethoxylneamine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[32] | |||
| Compound Name |
Neamine guanidinylated deriv. 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215269; 1,3,2,6-Tetraguanidinoneamine; BDBM11997; 1,3,2',6'-tetraguanidinoneamine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[32] | |||
| Compound Name |
1,3,2-Triguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3,2'-triguanidinoneamine; CHEMBL438810; BDBM12008; Neamine guanidinylated deriv. 23
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[32] | |||
| Compound Name |
Chembl4170455
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278367
Click to Show/Hide
|
||||
| Activity |
IC50 = 301100 nM
|
[19] | |||
| Compound Name |
Chembl4167291
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278365
Click to Show/Hide
|
||||
| Activity |
IC50 = 309300 nM
|
[19] | |||
| Compound Name |
(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927186; ZINC2698193; BDBM50359724; STK711873; AKOS002386597; ST50326453; AB00674549-01; F1542-0089
Click to Show/Hide
|
||||
| Activity |
IC50 = 310000 nM
|
[9] | |||
| Compound Name |
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 33 [PMID: 19908842]; CHEMBL578159; MLS002471784; GTPL8874; SCHEMBL3346407; HMS2213P07; HMS3348G08; BDBM50303436; NCGC00182115-01; NCGC00182115-02; SMR001395198; Q27076570; 9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 426579.52 nM
|
[18] | |||
| Compound Name |
Chembl4175156
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278390
Click to Show/Hide
|
||||
| Activity |
IC50 = 435800 nM
|
[19] | |||
| Compound Name |
Ethyl 5-{1-methyl-3-[(pyridin-4-ylmethyl)carbamoyl]-1H-pyrazol-5-yl}-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939874; SCHEMBL1313866; BDBM50361632; DB-124923; ethyl 5-[2-methyl-5-(pyridin-4-ylmethylcarbamoyl)pyrazol-3-yl]-1H-indole-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Ethyl 5-(methanesulfonamido)-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939861; SCHEMBL8408444; BDBM50361619
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
2-N-Ethyl-1H-indole-2,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939864; BDBM50361622
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Chembl4171886
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278388
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[19] | |||
| Compound Name |
Ethyl 5-acetamido-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939865; 1H-Indole-2-carboxylic acid, 5-(acetylamino)-, ethyl ester; ACMC-20mdru; Oprea1_783119; SCHEMBL6514040; CTK0G1996; DTXSID50350643; BDBM50361623; Ethyl 5-acetaminoindole-2-carboxylate; ethyl 5-acetylaminoindole-2-carboxylate; SR-01000519056; SR-01000519056-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Ethyl 5-(3-methylpyridin-4-yl)-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939871; BDBM50361629
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Ethyl 5-pyridin-2-yl-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939868; BDBM50361626
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
N-[2-(4,5-Dihydro-1,3-oxazol-2-yl)-1H-indol-5-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939866; BDBM50361624
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
2-Butanoyl-1H-indole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939863; BDBM50361621
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Ethyl 5-phenyl-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939867; 5-phenyl-2-carbethoxyindole; SCHEMBL419130; CTK1H9732; DTXSID30496679; BDBM50361625; 5-Phenyl-1H-indole-2-carboxylic Acid Ethyl Ester; 1H-Indole-2-carboxylic acid, 5-phenyl-, ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Ethyl 5-carbamoyl-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ethyl 5-carbamoylindole-2-carboxylate; CHEMBL1939862; SCHEMBL6517054; BDBM50361620; ZINC45287075; AKOS032960944; 5-Cabamoyl-2-indole carboxylic acid ethyl ester; Q27455014
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Hydroxamate deriv., 78
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BMCL1954 Compound 3; CHEMBL269834; SCHEMBL8357412; BDBM23487
Click to Show/Hide
|
||||
| Activity |
Ki = 2400000 nM
|
[33] | |||
| Compound Name |
(1R,2S)-1-({3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461220; SCHEMBL13648029; BDBM26524; hydroxamate-cyclopropyl compound, 1
Click to Show/Hide
|
||||
| Activity |
Ki = 4072000 nM
|
[33] | |||
| Compound Name |
(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL495555; SCHEMBL13648000; BDBM50292683
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[33] | |||
| Compound Name |
(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-methylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497810; SCHEMBL13648009; BDBM50292684
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[33] | |||
| Compound Name |
(1S,2R)-2-Cyano-N-hydroxy-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497769; BDBM50292680
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[33] | |||
| Compound Name |
(1R,2S)-1-(3-Fluoro-4-((2-phenylquinolin-4-yl)methoxy)benzyl)-N2-hydroxy-N1,N1-dimethylcyclopropane-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496309; SCHEMBL13648378; BDBM50292682
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[33] | |||
| Compound Name |
(1S,2R)-N-Hydroxy-2-((S)-2-(hydroxymethyl)pyrrolidine-1-carbonyl)-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL506057; SCHEMBL13648344; BDBM50292681
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[33] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose. J Med Chem. 2017 Jul 13;60(13):5933-5939. | ||||
| REF 2 | US patent application no. 9206139B2, Aggrecanase inhibitors | ||||
| REF 3 | Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. | ||||
| REF 4 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment ... Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. | ||||
| REF 5 | Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models. Eur J Med Chem. 2016 Mar 23;111:193-201. | ||||
| REF 6 | Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis. J Med Chem. 2014 Dec 26;57(24):10476-85. | ||||
| REF 7 | Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2242-6. | ||||
| REF 8 | Synthesis and SAR of highly selective MMP-13 inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6. | ||||
| REF 9 | Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization. Eur J Med Chem. 2012 Jan;47(1):143-52. | ||||
| REF 10 | Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87. | ||||
| REF 11 | Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4. | ||||
| REF 12 | Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies. Bioorg Med Chem. 2007 Jul 15;15(14):4753-66. | ||||
| REF 13 | Hydantoin based inhibitors of MMP13--discovery of AZD6605. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4705-12 | ||||
| REF 14 | Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. | ||||
| REF 15 | A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. | ||||
| REF 16 | Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors. Bioorg Med Chem. 2013 Nov 1;21(21):6456-65. | ||||
| REF 17 | Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models. J Med Chem. 2013 Oct 24;56(20):8089-103. | ||||
| REF 18 | Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. | ||||
| REF 19 | A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line. Eur J Med Chem. 2017 Dec 1;141:37-50. | ||||
| REF 20 | Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. | ||||
| REF 21 | Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13;56(11):4357-73. | ||||
| REF 22 | Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J Med Chem. 2007 Jul 26;50(15):3442-56. | ||||
| REF 23 | Selective non zinc binding inhibitors of MMP13. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4215-9. | ||||
| REF 24 | SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem. 2015 Aug 13;58(15):5808-24. | ||||
| REF 25 | Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):271-7. | ||||
| REF 26 | Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates. J Med Chem. 2008 Dec 25;51(24):7968-79. | ||||
| REF 27 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 28 | Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. | ||||
| REF 29 | Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. J Med Chem. 2008 Feb 28;51(4):835-41. | ||||
| REF 30 | Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem. 2004 Jan 15;47(2):325-36. | ||||
| REF 31 | Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases. Bioorg Med Chem Lett. 2002 Mar 25;12(6):933-6. | ||||
| REF 32 | Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5183-9. | ||||
| REF 33 | Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5809-14. | ||||
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