Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64205 | Target Info | |||
| Target Name | Signal transducer and activator of transcription 1 (STAT1) | ||||
| Synonyms |
Transcription factor ISGF-3 components p91/p84; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; STAT-1; P91
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|
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| Target Type | Patented-recorded Target | ||||
| Gene Name | STAT1 | ||||
| Biochemical Class | Transcription factor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 35 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID26394986-Compound-13
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|
Patented | Compound Info | ||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
6-Methyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1417722; MLS000083003; HMS2291O08; ZINC4038513; BDBM50189944; STL580382; AKOS032392945; MCULE-5790325702; SMR000046666
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(1,4,5,6-Tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828447; BDBM50189935
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(7-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1439622; MLS000061769; 2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-6-methylpyrimidin-4-ol; CBKinase1_001260; CBKinase1_013660; Cambridge id 5804772; Oprea1_009722; Oprea1_473001; BDBM91739; CS115; BDBM50103637; STK071741; ZINC18142679; AKOS001671536; CCG-203361; MCULE-2120371735; NCGC00054258-02; NCGC00054258-03; SMR000070238; EU-0011601; AB00097580-01; AB00097580-04; AB00097580-06; SR-01000493502; SR-01000493502-1; BRD-K54666543-001-01-0; 2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-6-methylpyrimidin-4(3H)-one; 2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-6-methyl-1H-pyrimidin-4-one; 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-6-methyl-4-pyrimidinol
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-(3,4-Dichlorophenyl)-7-(2-methylpropyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827334; BDBM50190101
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Pyridin-4-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828577; BDBM50189931
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(3,4-Dichlorophenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827273; BDBM50189986
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Cyclohexyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828502; BDBM50189945
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(5-Chlorothiophen-2-yl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828691; BDBM50189934
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
7-Benzyl-6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827967; BDBM50190103
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(4-Methoxyphenyl)-7-(2-methylpropyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828107; BDBM50190102
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(4-Methoxyphenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827821; SCHEMBL17934695; BDBM50189953
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(3,4-Dichlorophenyl)-7,7-dimethyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827607; BDBM50190106
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-(2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1342513; SMR000046525; MLS000083018; MLS002583898; SCHEMBL17934714; HMS2273G23; ZINC4038546; BDBM50189924; STK566965; AKOS005492633; AKOS032392600; CCG-275086; MCULE-3068522115
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1432718; MLS000083005; HMS2329L20; BDBM50189943; SMR000047092
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Ethoxy-4-methyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1319541; HMS2353O20; ZINC5593104; BDBM50103643; STL485055; AKOS037484064
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Phenyl-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1425853; SMR000046708; MLS000082997; MLS002583894; SCHEMBL10016545; HMS2306H09; ZINC4038543; BDBM50189928; STL055977; AKOS005708754; AKOS032393079; MCULE-4126279843
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Schembl20866490
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827123; BDBM50190100
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(3,4-Dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000083032; CHEMBL1527817; SMR000047142; MLS002583900; cid_665910; REGID_for_CID_665910; SCHEMBL17927738; BDBM42473; HMS2384F15; ZINC5075220; BDBM50189922; STL041638; AKOS005695188; AKOS032394257; CCG-275088; MCULE-4208521268
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4,6-Dimethyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3337603; BDBM50103640
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000558549; SMR000149065; CHEMBL1344250; SCHEMBL20866520; BDBM79531; cid_1400670; HMS2446H15; ZINC5460698; STL051781; AKOS005704660; AKOS032393880; MCULE-4027782697
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(3-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828538; BDBM50189925
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5,6-Dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1652424; Oprea1_482207; Oprea1_668777; SCHEMBL15840657; BDBM50103829; BDBM50335548; CCG-20804; STK009843; STK846294; ZINC18190126; AKOS002223018; AKOS002529544; AKOS005627021; MCULE-3421208496; EU-0045759; ST50104991; AB00117160-01; SR-01000498951; SR-01000498951-1; 5,6-Dimethyl-2-(4,6,8-trimethylquinazolin-2-ylamino)-1H-pyrimidin-4-one; 5,6-dimethyl-2-(4,6,8-trimethylquinazolin-2-ylamino)pyrimidin-4-ol; 5,6-dimethyl-2-[(4,6,8-trimethyl-2-quinazolinyl)amino]-4(1H)-pyrimidinone; 5,6-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]hydropyrimidin-4-one
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-(5-Chlorothiophen-2-yl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828202; BDBM50189933
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(3-Phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827729; BDBM50189936
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(3,4-Dichlorophenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827948; SCHEMBL17927734; BDBM50189952
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(3,4-Dichlorophenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828058; C19H12Cl2N6S; ZINC9360650; BDBM50189923; STL049278; AKOS005702594; AKOS032393260; MCULE-5589996498
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Phenyl-3-(2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1564640; MLS000082998; HMS2308B14; BDBM50189927; STL056101; AKOS005709115; SMR000046750
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(4-Methoxyphenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828475; ZINC6786180; BDBM50189930; STL052693; AKOS005705767; AKOS032394061; MCULE-4861402064
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(1S,3R,4S,5R,6R,8R,9S,12R,13R)-13-Ethenyl-5-hydroxy-4,9,12-trimethyl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecan-11-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938768; BDBM50207366
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(7-Ethoxy-4-methylquinazolin-2-yl)(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1528359; DNDI1417388; MLS000027423; ZINC28976; HMS2333B17; BDBM50103749; STK098795; STK558875; AKOS001744895; AKOS005484485; MCULE-5149087781; NCGC00018972-01; SMR000034333; ST041681; EU-0008545; ST50750005; SR-01000465654; SR-01000465654-1
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(3-Phenyl-1H-pyrazol-5-yl)-6-pyridin-4-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827646; BDBM50189932
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Cyclohexyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827868; BDBM50189946
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[(5R,5As,9R,9aR,9bR)-9,9b-dihydroxy-6,6,9a-trimethyl-1-oxo-3,5,5a,7,8,9-hexahydrobenzo[e][2]benzofuran-5-yl] hexanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261196; BDBM50016099
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|
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| Activity |
IC50 = 50700 nM
|
[5] | |||
| Compound Name |
STAT5 Inhibitor
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|
Investigative | Compound Info | ||
| Synonyms |
STAT5-IN-1; STAT5; N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide; N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide; N-[(E)-(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide; SCHEMBL2563928; CHEMBL1241908; CCG-1475; EX-A2552; MFCD00124694; CS-6859; BS-16416; HY-101853; S6784; STAT5 Inhibitor 1 [285986-31-4]; EC-000.2533; J-017149; SR-01000638229-1; (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
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||||
| Activity |
IC50 = 130000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-1-[(3-hydroxypropyl)carbamoyl]-3-methylbutyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234466; ISS835; BDBM20275
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|
||||
| Activity |
IC50 = 210000 nM
|
[7] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-3-methyl-1-[(2-methylpropyl)carbamoyl]butyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234465; ISS841; BDBM20280
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|
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| Activity |
IC50 = 250000 nM
|
[7] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-3-methyl-1-(phenylcarbamoyl)butyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438852; ISS838; BDBM20277
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|
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| Activity |
IC50 = 380000 nM
|
[7] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-3-methyl-1-[(pyridin-4-ylmethyl)carbamoyl]butyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234817; ISS843; BDBM20281
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|
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| Activity |
IC50 = 402000 nM
|
[7] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-1-[(3-methoxyphenyl)carbamoyl]-3-methylbutyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412549; ISS840; BDBM20279
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|
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| Activity |
IC50 = 560000 nM
|
[7] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-1-(cyclohexylcarbamoyl)-3-methylbutyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393817; ISS836; BDBM20276
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|
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| Activity |
IC50 = 605000 nM
|
[7] | |||
| Compound Name |
4-[(2S)-2-{[(1S)-1-(Benzylcarbamoyl)-3-methylbutyl]carbamoyl}-2-[(4-cyanophenyl)formamido]ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398067; ISS839; BDBM20278
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|
||||
| Activity |
IC50 = 760000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem. 2012 Aug 9;55(15):6645-68. | ||||
| REF 2 | Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3581-5. | ||||
| REF 3 | 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5081-5. | ||||
| REF 4 | Anti-inflammatory tetraquinane diterpenoids from a Crinipellis species. Bioorg Med Chem. 2017 Jan 15;25(2):514-522. | ||||
| REF 5 | Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species. Bioorg Med Chem. 2014 Jun 1;22(11):2912-8. | ||||
| REF 6 | Inhibitors of Stat5 protein signalling. Medchemcomm. 2012;3:22-7. | ||||
| REF 7 | Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. | ||||
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