Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63083 | Target Info | |||
| Target Name | DNA repair protein RAD51 homolog 1 (RAD51) | ||||
| Synonyms |
hRAD51; RECA; RAD51A; RAD51 homolog A; HsRAD51
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| Target Type | Clinical trial Target | ||||
| Gene Name | RAD51 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 30 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(4-Aminophenyl)-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316730; SCHEMBL17202955; BDBM50424493; 3-(4-Aminophenyl)-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(3,4-Dichlorophenyl)-3-(4-(dimethylamino)phenyl)-4-morpholino-1H-pyrrole-2,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316728; SCHEMBL17201949; BDBM50424494; 1-(3,4-dichlorophenyl)-3-[4-(dimethylamino)phenyl]-4-morpholin-4-ylpyrrole-2,5-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Schembl20816315
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824216; BDBM50184341
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| Activity |
IC50 = 57800 nM
|
[2] | |||
| Compound Name |
Schembl20816312
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823341; BDBM50184375
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| Activity |
IC50 = 64900 nM
|
[2] | |||
| Compound Name |
4-Pyridin-3-ylpyrrolo[1,2-a]quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823966; BDBM50184333; NSC753553; NSC-753553
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| Activity |
IC50 = 71700 nM
|
[2] | |||
| Compound Name |
4-Pyridin-4-ylpyrrolo[1,2-a]quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822942; SCHEMBL20816323; BDBM50184334; NSC753554; NSC-753554
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| Activity |
IC50 = 79400 nM
|
[2] | |||
| Compound Name |
Schembl20816302
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823899; BDBM50184344
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| Activity |
IC50 = 81500 nM
|
[2] | |||
| Compound Name |
Schembl20816333
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824220; BDBM50184407
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| Activity |
IC50 = 91100 nM
|
[2] | |||
| Compound Name |
Schembl20816317
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823002; BDBM50184342
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| Activity |
IC50 = 96900 nM
|
[2] | |||
| Compound Name |
Schembl20816334
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824268; BDBM50184336
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816308
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822556; BDBM50184340
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(7-Methoxy-4,5-dihydropyrrolo[1,2-a]quinoxalin-4-yl)-N,N-dimethylaniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1547184; Maybridge2_000129; Oprea1_261606; MLS000860659; SCHEMBL20816309; HMS1303F19; HMS2812D24; BDBM50184397; CCG-237386; MCULE-4702598844; IDI1_001169; SMR000458743; J3.600.956J; 4,5-Dihydro-4-[4-(dimethylamino)phenyl]-7-methoxypyrrolo[1,2-a]quinoxaline
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816342
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823737; BDBM50184316
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215812; BDBM50416563
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Schembl20816307
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823654; BDBM50184378
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(Cyclohexen-1-yl)pyrrolo[1,2-a]quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL224458; SCHEMBL20816321; BDBM50184335
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816330
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822575; BDBM50184322
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816301
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824107; BDBM50184339
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816320
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822905; BDBM50184317
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816322
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823373; BDBM50184337
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816310
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823677; BDBM50184406
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816303
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824080; BDBM50184319
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816332
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822797; BDBM50184345
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816298
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823629; BDBM50184321
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816314
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824180; BDBM50184338
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816324
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823840; BDBM50184373
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816328
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823248; BDBM50184374
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823105; SCHEMBL20816311; BDBM50184320; ZINC585091605
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(4-Nitrophenyl)pyrrolo[1,2-a]quinoxaline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823934; SCHEMBL20816329; BDBM50184318; J3.526.701H
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl20816300
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823795; BDBM50184372
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem. 2013 Jan 10;56(1):254-63. | ||||
| REF 2 | Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25. | ||||
| REF 3 | Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide. J Med Chem. 2010 Aug 12;53(15):5782-91. | ||||
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