Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62553 | Target Info | |||
| Target Name | Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) | ||||
| Synonyms |
HSV Ribonucleotide reductase; HSV Ribonucleoside diphosphate reductase; HSV RIR1
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|
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| Target Type | Discontinued Target | ||||
| Gene Name | HSV RIR1 | ||||
| Biochemical Class | CH/CH(2) oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 34 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
D-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162068; BDBM50013356
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Thr-Asp-Phe-Phe-Glu-Cys-Arg-Ser-Thr-Ser-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371374; BDBM50013353
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
(2S,3S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-3-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL163585; BDBM50013375; Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Ile; Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Phe
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
Lys-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL387234; BDBM50013351
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
Phe-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434294; BDBM50013378
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
His-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL350125; BDBM50013373
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Val
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349654; BDBM50013380
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
Leu-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349664; BDBM50013350
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-Lys
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL265148; BDBM50013355
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[3-(4-hydroxyphenyl)propanoylamino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423453; BDBM50013345; desamino-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu; (desamino-Tyr)-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Tyr(OMe)-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162403; BDBM50013348
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-amino-4-oxo-butanoyl]amino]-4-[[(1S)-1-carbamoyl-3-methyl-butyl]amino]-4-oxo-butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434089; BDBM50013349; Ac-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-NH2; Ac-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-NH2
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-amino-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434474; BDBM50013371; Ac-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-OH; Ac-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Glu-Cys-Arg-Ser-Thr-Ser-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371380; BDBM50013364
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Tyr-Ala-Gly-Ala-Val-Ala-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164048; BDBM50013360
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Ac-Tyr(OMe)-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162176; BDBM50013362
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Tyr-gly-ala-val-val-asn-asp-leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162321; BDBM50013367
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Ser-Thr-Ser-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412159; BDBM50013357
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Ac-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL351157; BDBM50013359
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162919; Tyr-Ala-Val-Val-Asn-Asp-Leu; BDBM50013365; NH2-Tyr-Ala-Val-Val-Asn-Asp-Leu-OH
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2079667; Tyr-D-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu; BDBM50406321; Tyr-beta.-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Tyr-beta-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165071; BDBM50013379
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|
||||
| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(3S)-3-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-oxo-butanoyl]amino]-4-[[(1S)-1-carbamoyl-3-methyl-butyl]amino]-4-oxo-butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165060; BDBM50013374; Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-NH2; NH2-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-NH2
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Ala-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162547; BDBM50013368
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Ac-Tyr-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436439; BDBM50013361
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Ac-D-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL351856; BDBM50013369
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790768; BDBM50366468
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-amino-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264705; Ac-Ala-Val-Val-Asn-Asp-Leu-OH; BDBM50013346; Ac-Tyr-Ala-Gly-Val-Val-Asn-Asp-Leu
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-4-amino-4-oxo-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421853; BDBM50013352; Ac-Tyr-D-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Tyr-C8-Val-Val-Asn-Asp-Leu
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL350585; BDBM50013383
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|
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| Activity |
IC50 = 63000 nM
|
[1] | |||
| Compound Name |
(S)-2-{(S)-3-Carboxy-2-[(1-{(S)-2-[3-(1-ethyl-propyl)-ureido]-3,3-dimethyl-butyryl}-pyrrolidine-2-carbonyl)-amino]-propionylamino}-4-methyl-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369480; BDBM50050836
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|
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-propyl)-ureido]-3,3-dimethyl-butyrylamino}-propionylamino)-propionylamino]-4-methyl-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL68193; BDBM50050832
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| Activity |
IC50 = 110000 nM
|
[2] | |||
| Compound Name |
Tyr-Thr-Met-Leu-Val-Val-Asn-Asp-Leu
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371373; BDBM50013372
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|
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| Activity |
IC50 = 110000 nM
|
[1] | |||
| Compound Name |
(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-methyl-butyrylamino]-3-methyl-butyrylamino}-3-carbamoyl-propionylamino)-3-carboxy-propionylamino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318787; Ala-Val-Val-Asn-Asp-Leu; H-Ala-Val-Val-Asn-Asp-Leu-OH; BDBM50013366; L-Leucine, L-alanyl-L-valyl-L-valyl-L-asparaginyl-L-alpha-aspartyl-
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| Activity |
IC50 = 190000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409888; BDBM50013354; H-Gly-Ala-Val-Val-Asn-Asp-Leu-OH
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| Activity |
IC50 = 225000 nM
|
[1] | |||
| Compound Name |
Ala-Gly-Ala-Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103140; BDBM50013381; H-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-OH
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|
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| Activity |
IC50 = 283000 nM
|
[1] | |||
| Compound Name |
(S)-2-{(S)-3-Carboxy-2-[(1-{(S)-2-[3-(1-ethyl-propyl)-ureido]-3,3-dimethyl-butyryl}-piperidine-2-carbonyl)-amino]-propionylamino}-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369481; BDBM50050823
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| Activity |
IC50 = 750000 nM
|
[2] | |||
| Compound Name |
Val-Val-Asn-Asp-Leu
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|
Investigative | Compound Info | ||
| Synonyms |
H-Val-Val-Asn-Asp-Leu-OH; CHEMBL102379; SCHEMBL9848679; BDBM50013358
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| Activity |
IC50 = 760000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and inhibitory potency of peptides corresponding to the subunit 2 C-terminal region of herpes virus ribonucleotide reductases. J Med Chem. 1990 Feb;33(2):723-30. | ||||
| REF 2 | Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation. J Med Chem. 1996 May 24;39(11):2178-87. | ||||
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