Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61657 | Target Info | |||
| Target Name | Retinoic acid receptor beta (RARB) | ||||
| Synonyms |
RAR-epsilon; RAR-beta; Nuclear receptor subfamily 1 group B member 2; NR1B2; HBV-activated protein; HAP
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| Target Type | Successful Target | ||||
| Gene Name | RARB | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-((+/-)-(1H-imidazol-1-yl)-(E)-retinoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57765; 4-((+/-)-(1H-imidazol-1-yl)-(E)-retinoic acid; SCHEMBL1234027; 4-(1-Imidazolyl)retinoic acid; BDBM50091698; (2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid
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| Activity |
IC50 = 175000 nM
|
[1] | |||
| Compound Name |
N-(1H-1,2,4-Triazol-1-yl)-(E)-retinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388283; SCHEMBL3706627; BDBM50158413
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| Activity |
IC50 = 90000 nM
|
[1] | |||
| Compound Name |
(E)-3-[4-(4-Hydroxyphenyl)phenyl]prop-2-enoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL187836; SCHEMBL3293830; SCHEMBL3293835; BDBM50170869; ZINC13648522; (E)-3-(4''-Hydroxy-biphenyl-4-yl)-acrylic acid
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-3-[4-(4-Hydroxy-3-phenylphenyl)phenyl]prop-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL189565; BDBM50170868; (E)-3-(4''-Hydroxy-[1,1'';3'',1'''']terphenyl-4-yl)-acrylic acid
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-((+/-)-(1H-Imidazol-1-yl)-(13Z)-retinoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL387639; SCHEMBL17769833; BDBM50158416
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| Activity |
IC50 = 175000 nM
|
[1] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-3-[1,2,4]triazol-4-yl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL53449; SCHEMBL1232072; BDBM50091699; 4-((+/-)-(1H-1,2,4-triazol-4-yl)-(E)-retinoic acid
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| Activity |
IC50 = 250000 nM
|
[1] | |||
| Compound Name |
N-(1H-Imidazole-1-yl)-(E)-retinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388064; SCHEMBL3698734; BDBM50158412
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| Activity |
IC50 = 500000 nM
|
[1] | |||
| Compound Name |
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-3-[1,2,4]triazol-1-yl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417769; SCHEMBL1233540; BDBM50091700; 4-((+/-)-(1H-1,2,4-triazol-1-yl)-(E)-retinoic acid
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| Activity |
IC50 = 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and pros... J Med Chem. 2004 Dec 30;47(27):6716-29. | ||||
| REF 2 | Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. J Med Chem. 2005 Jul 28;48(15):4931-46. | ||||
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