Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61518 | Target Info | |||
| Target Name | Tyrosine-protein kinase MELK (MELK) | ||||
| Synonyms |
pEg3 kinase; hPK38; hMELK; MELK
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| Target Type | Clinical trial Target | ||||
| Gene Name | MELK | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4276946
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|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Fluoro-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355053; BDBM50043333; AKOS013216008; Q27464703; QBB
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| Activity |
IC50 = 160000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 2 | Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30. | ||||
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