Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60897 | Target Info | |||
| Target Name | Protein tyrosine phosphatase IVA 2 (PRL-2) | ||||
| Synonyms |
Protein-tyrosine phosphatase of regenerating liver 2; Protein-tyrosine phosphatase 4a2; Protein tyrosine phosphatase type IVA 2; PTPCAAX2; PTP(CAAXII); PRL2; OV-1; HU-PP-1; BM-008
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| Target Type | Literature-reported Target | ||||
| Gene Name | PTP4A2 | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Propan-2-yl (E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoprop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393149; ZINC5118815; BDBM50059141
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| Activity |
IC50 = 69400 nM
|
[1] | |||
| Compound Name |
7-Amino-2-phenylthieno[3,2-c]pyridin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393171; SCHEMBL18323039; BDBM50059084; HY-128153; CS-0095376; J3.515.308J; 7-amino-2-phenyl-5H-thieno[3,2-c]pyridin-4-one; 2-Phenyl-7-amino-4,5-dihydrothieno[3,2-c]pyridine-4-one
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| Activity |
IC50 = 104000 nM
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[1] | |||
| Compound Name |
Prop-2-enyl (E)-3-(3-bromo-4-hydroxyphenyl)-2-cyanoprop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393146; ZINC6947664; BDBM50059086; AKOS001276092
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| Activity |
IC50 = 104000 nM
|
[1] | |||
| Compound Name |
Ethyl (2E)-2-cyano-3-(3,5-dibromo-4-hydroxyphenyl)prop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393150; BBL019231; BDBM50059142; MFCD06210268; STL199340; ZINC72334076; AKOS017082913; VS-06890
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| Activity |
IC50 = 109200 nM
|
[1] | |||
| Compound Name |
Propan-2-yl (2Z)-3-(3-bromo-4-hydroxyphenyl)-2-cyanoprop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393151; BDBM50059143; CAK109693; NCGC00333225-01; AB01328271-02
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| Activity |
IC50 = 149800 nM
|
[1] | |||
| Compound Name |
8-Carboxy-2-phenyl[1,3]thiazolo[3,2-a]pyridin-4-ium-3-olate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393147; BDBM50059139; STK922327; AKOS002312449; MCULE-7085291378; ST50758455; VU0608624-1; F3281-0063; 8-carboxy-2-phenylthiazolo[3,2-a]pyridin-4-ium-3-olate; 3-hydroxy-2-phenyl-1,3-thiazolo[3,2-a]pyridine-8-carboxylic acid
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| Activity |
IC50 = 188000 nM
|
[1] | |||
| Compound Name |
2-{5-[(E)-(4-Oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CK2/PIM1-IN-1; CHEMBL398538; SCHEMBL3424039; 2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid; ZINC970452; BDBM50237949; STK156908; STL559196; AKOS000323731; HY-135816; CS-0114271; ST51012004; 2-[5-[[(5E)-2-Thioxo-4-oxothiazolidine-5-ylidene]methyl]-2-furyl]benzoic acid; 2-{5-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid
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| Activity |
IC50 = 188000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
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| REF 1 | Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver. Eur J Med Chem. 2014 Dec 17;88:89-100. | ||||
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