Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60514 | Target Info | |||
| Target Name | Platelet glycoprotein VI (GP6) | ||||
| Synonyms |
Glycoprotein 6; GPVI
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| Target Type | Clinical trial Target | ||||
| Gene Name | GP6 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Losartan Carboxaldehyde
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Investigative | Compound Info | ||
| Synonyms |
UNII-KJ52CU0VV6; EXP 3179; KJ52CU0VV6; CHEMBL308493; Losartan Carboxaldehyde;DuP 167; E-3179; losartancarbaldehyde; EXP-3179; Losartan EP Impurity K; Losartan potassium specified impurity K [EP]; SCHEMBL860; Losartan Related Compound C; CTK8E7662; DTXSID80150855; ZINC1552042; Losartan carboxaldehyde [EXP3179]; BDBM50211282; AS-74776; FT-0670857; L001962; J-003136; Q27282284; 2-butyl-4-chloro-5-formyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
2-[4-Methoxybenzenesulfonyl]-1,2,3,4,-tetrahydro-9h-pyrido[3,4-b]indole-3-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959435; SCHEMBL3864446; BDBM50211284
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| Activity |
IC50 = 53500 nM
|
[1] | |||
| Compound Name |
(3R)-2-(4-Methoxyphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2263356; BDBM50211283
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| Activity |
IC50 = 86800 nM
|
[1] | |||
| Compound Name |
(3S)-2-(4-Methoxyphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
S007-1558 (S); CHEMBL2263357; BDBM50211280
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| Activity |
IC50 = 181400 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel Glycoprotein VI Antagonists as Antithrombotics: Synthesis, Biological Evaluation, and Molecular Modeling Studies on 2,3-Disubstituted Tetrahydropyrido(3,4-b)indoles. J Med Chem. 2017 Jan 12;60(1):322-337. | ||||
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