Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59604 | Target Info | |||
| Target Name | Growth hormone secretagogue receptor 1 (GHSR) | ||||
| Synonyms |
Growth hormone secretagogue receptor; Ghrelin receptor; GHSR; GHS-R; GHRP; GH-releasing peptide receptor
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| Target Type | Successful Target | ||||
| Gene Name | GHSR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R)-2-[[(2S)-2-[[(2S)-2-[[[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]amino]-benzylcarbamoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-amino-1-oxopropan-2-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163439; SCHEMBL13222067; BDBM50395029
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[(2S)-2-(2-Aminoacetamido)-3-hydroxypropanamido]-2-{[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}ethyl heptanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL447282; BDBM50267266
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[[[(2R)-2-[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-(2-methylpropyl)carbamoyl]amino]-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163468; BDBM50394981
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| Activity |
IC50 = 85600 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[(2S)-2-(2-Aminoacetamido)-3-hydroxypropanamido]-2-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}ethyl heptanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476471; BDBM50267267
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| Activity |
IC50 = 889000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a. J Med Chem. 2012 Jul 26;55(14):6502-11. | ||||
| REF 2 | Fluorine and rhenium substituted ghrelin analogues as potential imaging probes for the growth hormone secretagogue receptor. J Med Chem. 2009 Apr 23;52(8):2196-203. | ||||
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