Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T58454 | Target Info | |||
Target Name | Fibroblast growth factor receptor 2 (FGFR2) | ||||
Synonyms |
Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; KSAM; KGFR; K-sam; FGFR-2; FGF-2 receptor; CD332; BEK
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Target Type | Successful Target | ||||
Gene Name | FGFR2 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
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Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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Activity |
IC50 ~ 50000 nM
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[1] | |||
Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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Activity |
IC50 ~ 50000 nM
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[2] | |||
Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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Activity |
IC50 ~ 50000 nM
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[3] | |||
Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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Activity |
IC50 ~ 50000 nM
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[2] | |||
Compound Name |
CID 49806721
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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Activity |
IC50 ~ 50000 nM
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[4] | |||
Compound Name |
Chembl4173432
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Investigative | Compound Info | ||
Synonyms |
BDBM50280107
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Activity |
IC50 = 52000 nM
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[5] | |||
Click to Show/Hide the Information of All Poor Binders |
References | Top | ||||
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REF 1 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
REF 2 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
REF 3 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
REF 4 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
REF 5 | Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ACS Med Chem Lett. 2017 Nov 11;8(12):1264-1268. |
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