Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58298 | Target Info | |||
| Target Name | Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) | ||||
| Synonyms |
NTPDase1; NTPDase 1; Lymphoid cell activation antigen; Ecto-nucleotidase CD-39; Ecto-apyrase; Ecto-ATPase 1; Ecto-ATPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATP diphosphohydrolase; CD39 antigen; ATPDase
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| Target Type | Clinical trial Target | ||||
| Gene Name | ENTPD1 | ||||
| Biochemical Class | Acid anhydride hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S,3S,4R,5R)-N-[3-[4-(Diethoxyphosphorylmethyl)anilino]-3-oxopropyl]-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolane-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL511933; SCHEMBL13210974; BDBM50262250
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| Activity |
Ki = 55200 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-N-[3-[4-(diethoxyphosphorylmethyl)anilino]-3-oxopropyl]-3,4-dihydroxyoxolane-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517017; SCHEMBL13210999; BDBM50262372
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| Activity |
Ki = 154000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-N-[4-[4-(diethoxyphosphorylmethyl)anilino]-4-oxobutyl]-3,4-dihydroxyoxolane-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464548; SCHEMBL13211002; BDBM50262373
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| Activity |
Ki = 161000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5R)-N-[4-[4-(Diethoxyphosphorylmethyl)anilino]-4-oxobutyl]-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolane-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL463519; SCHEMBL13210975; BDBM50262251
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| Activity |
Ki = 182000 nM
|
[1] | |||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4164185
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276785
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4165654
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276782
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4172790
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276786
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4172933
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276780
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4174849
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276790
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4159530
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276784
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4175913
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276789
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4161473
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276794
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4173693
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276787
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4159729
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276781
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|
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4162261
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276788
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4164891
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276791
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4169839
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276783
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|
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
(2S,3S,4R,5R)-N-[2-(Diethoxyphosphorylmethylamino)-2-oxoethyl]-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolane-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468354; SCHEMBL13210978; BDBM50262252
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|
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| Activity |
Ki = 786000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem. 2008 Aug 14;51(15):4518-28. | ||||
| REF 2 | Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors. Eur J Med Chem. 2017 Sep 29;138:816-829. | ||||
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