Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57560 | Target Info | |||
| Target Name | Bacterial Penicillin binding protein 1 (Bact pbp) | ||||
| Synonyms |
Penicillin-binding protein 1; PBP1; PBP-1; Bact pon
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| Target Type | Clinical trial Target | ||||
| Gene Name | Bact mrcA; Bact mrcB; Bact pbpC | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sodium;(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(Z)-2-(1,3-thiazol-5-yl)ethenyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL332565
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| Activity | Bacterial Penicillin binding protein 1B |
IC50 > 10000000 nM
|
[1] | ||
| Compound Name |
(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-5-yl-vinyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL333330; BDBM50053175
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| Activity | Bacterial Penicillin binding protein 1B |
IC50 > 10000000 nM
|
[1] | ||
| Compound Name |
Sodium;(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(Z)-2-pyridin-2-ylethenyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121924
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| Activity | Bacterial Penicillin binding protein 1B |
IC50 > 10000000 nM
|
[1] | ||
| Compound Name |
(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[(E)-3-pyridin-1-ium-1-ylprop-1-enyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trifluoromethanesulfonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123481
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| Activity | Bacterial Penicillin binding protein 1B |
IC50 > 10000000 nM
|
[1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases. J Med Chem. 1996 Sep 13;39(19):3712-22. | ||||
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