Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57361 | Target Info | |||
| Target Name | Kallikrein-related peptidase (KLK) | ||||
| Synonyms |
Human kallikrein
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|
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 64 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2315239
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|
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| Activity | Kallikrein 1 |
Ki ~ 50000 nM
|
[1] | ||
| Compound Name |
1-Phenyl-2-(5-carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-1,4-dihydropyridine-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093806; BDBM50444295
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| Activity | Kallikrein 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059991; BDBM50256261
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|
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| Activity | Kallikrein 5 |
Ki = 50000 nM
|
[3] | ||
| Kallikrein 1 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 2 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 14 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 6 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 13 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 12 |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
4-[4-(4-Hydroxy-phenyl)-phthalazin-1-ylamino]-N-methyl-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1462676; Cambridge id 7235017; MLS001212820; HMS2833P12; BDBM50444600; STK081312; AKOS000664808; ZINC100627035; MCULE-9143457757; SMR000523125; 4-{[4-(4-hydroxyphenyl)phthalazin-1-yl]amino}-N-methylbenzamide
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| Activity | Kallikrein 7 |
Ki = 50000 nM
|
[4] | ||
| Kallikrein 14 |
IC50 = 96000 nM
|
[4] | |||
| Compound Name |
1-Adamantyl N-[(2R)-1-[[(1S)-2-[[1-[4-(diaminomethylideneamino)phenyl]-4,4,4-trifluoro-3-oxobutan-2-yl]amino]-1-naphthalen-2-yl-2-oxoethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160805
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|
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| Activity | Kallikrein 1 |
Ki ~ 50000 nM
|
[5] | ||
| Compound Name |
(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094403; BDBM50256260
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|
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| Activity | Kallikrein 1 |
Ki ~ 50000 nM
|
[3] | ||
| Kallikrein 14 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 5 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 6 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 13 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 12 |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(Benzothiazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093815; BDBM50444297
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|
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| Activity | Kallikrein 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
2-(5-Carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093814; BDBM50444296
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|
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| Activity | Kallikrein 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,49S)-19-(4-Aminobutyl)-49-(2-amino-2-oxoethyl)-4,28-bis[(2S)-butan-2-yl]-25-[3-(diaminomethylideneamino)propyl]-22-(hydroxymethyl)-34-(1H-indol-3-ylmethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623791; BDBM50125028
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|
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| Activity | Kallikrein 5 |
Ki ~ 50000 nM
|
[6] | ||
| Compound Name |
Chembl4213650
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459528
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| Activity | Kallikrein 6 |
IC50 ~ 50000 nM
|
[7] | ||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070056; BDBM50256262
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|
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| Activity | Kallikrein 1 |
Ki = 50000 nM
|
[3] | ||
| Kallikrein 6 |
Ki ~ 50000 nM
|
[3] | |||
| Kallikrein 12 |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(13S)-13-Benzyl-11-(2-methylphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125572; BDBM50073222
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|
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| Activity | Kallikrein 7 |
Ki = 50600 nM
|
[8] | ||
| Compound Name |
Vioxanthin
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|
Investigative | Compound Info | ||
| Synonyms |
UNII-9C67W47A7M; CHEMBL1834754; 9C67W47A7M; Tf-26Vx; Antibiotic Tf26Vx; CTK8E0342; DTXSID001017880; BDBM50355088; NSC729023; NSC-729023; Q27272343
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|
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| Activity | Kallikrein 5 |
IC50 = 53700 nM
|
[9] | ||
| Kallikrein 7 |
IC50 = 135300 nM
|
[9] | |||
| Compound Name |
{1-[1-(4-Amino-1-formyl-butylcarbamoyl)-2-methyl-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371655; BDBM50012996
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|
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| Activity | Kallikrein 1 |
IC50 = 53800 nM
|
[10] | ||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109168; BDBM50446216
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|
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| Activity | Kallikrein 5 |
IC50 = 53900 nM
|
[11] | ||
| Kallikrein 7 |
IC50 = 84500 nM
|
[11] | |||
| Compound Name |
(2Z)-2-Benzimidazol-2-yl-3-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)phenyl]p rop-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099878; ZINC4453116; BDBM50444598; AKOS000605166; ST50282865
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|
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| Activity | Kallikrein 7 |
Ki = 55000 nM
|
[4] | ||
| Kallikrein 14 |
IC50 = 108000 nM
|
[4] | |||
| Kallikrein 5 |
Ki = 121000 nM
|
[4] | |||
| Compound Name |
(13S)-13-Benzyl-11-(3,4,5-trimethoxyphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408421; BDBM50073228
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|
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| Activity | Kallikrein 7 |
IC50 = 55700 nM
|
[8] | ||
| Compound Name |
Benzyl N-[(2S)-1-[[(2R)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109060; BDBM50446229
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|
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| Activity | Kallikrein 7 |
IC50 = 56600 nM
|
[11] | ||
| Compound Name |
Chembl4202434
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20037288; BDBM50459532
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|
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| Activity | Kallikrein 6 |
IC50 = 58000 nM
|
[7] | ||
| Compound Name |
[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2R)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109162; BDBM50446222
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|
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| Activity | Kallikrein 7 |
IC50 = 59200 nM
|
[11] | ||
| Compound Name |
(13S)-13-Benzyl-11-(4-methylphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125570; BDBM50073230
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|
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| Activity | Kallikrein 7 |
IC50 = 68000 nM
|
[8] | ||
| Compound Name |
(2Z)-2-Cyano-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)prop-2-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099870; BDBM50444604; ZINC12418985; AKOS024279418; ST026815; SR-01000218255; SR-01000218255-1
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| Activity | Kallikrein 7 |
Ki = 70000 nM
|
[4] | ||
| Kallikrein 14 |
IC50 = 106000 nM
|
[4] | |||
| Kallikrein 5 |
Ki = 112000 nM
|
[4] | |||
| Compound Name |
N-[(Z)-3-[[(3R,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-(furan-2-yl)-3-oxoprop-1-en-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2087346; BDBM50391078
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|
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| Activity | Kallikrein 5 |
Ki = 70400 nM
|
[12] | ||
| Compound Name |
N-[(Z)-3-[[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-oxo-1-thiophen-2-ylprop-1-en-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109056; BDBM50446227
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| Activity | Kallikrein 5 |
Ki = 70700 nM
|
[11] | ||
| Compound Name |
N-[(Z)-3-[[(3R,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-oxo-1-thiophen-2-ylprop-1-en-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2087343; BDBM50391075
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|
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| Activity | Kallikrein 5 |
Ki = 70700 nM
|
[12] | ||
| Compound Name |
(Z)-N-[(3R,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-2-acetamido-3-thiophen-2-ylprop-2-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2087347; BDBM50391079
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|
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| Activity | Kallikrein 5 |
Ki = 71900 nM
|
[12] | ||
| Kallikrein 7 |
Ki = 77400 nM
|
[12] | |||
| Compound Name |
(13S)-13-Benzyl-11-(4-methoxyphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125571; BDBM50073231
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|
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| Activity | Kallikrein 7 |
IC50 = 72000 nM
|
[8] | ||
| Compound Name |
(Z)-2-Cyano-3-(4-hydroxy-3-methoxyphenyl)-N-(4-methoxyphenyl)prop-2-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099874; ZINC5023753; BDBM50444602; SR-01000218328; SR-01000218328-1
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| Activity | Kallikrein 7 |
Ki = 72000 nM
|
[4] | ||
| Kallikrein 14 |
IC50 = 99000 nM
|
[4] | |||
| Kallikrein 5 |
Ki = 100000 nM
|
[4] | |||
| Compound Name |
8,8'-Paepalantine dimer
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834753; NSC724592; BDBM50355086; NSC-724592
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| Activity | Kallikrein 5 |
IC50 = 72900 nM
|
[9] | ||
| Kallikrein 7 |
IC50 = 112400 nM
|
[9] | |||
| Compound Name |
2-((3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)amino)-2-oxoethyl 2-(2-methyl-1H-indol-3-yl)acetate
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Investigative | Compound Info | ||
| Synonyms |
DKFZ-251; CHEMBL4218203; SCHEMBL20037008; GTPL10575; TQP0912; BDBM50459538; compound 11 [PMID: 30212625]; [2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-(2-methyl-1H-indol-3-yl)acetate
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| Activity | Kallikrein 7 |
IC50 = 73000 nM
|
[7] | ||
| Compound Name |
(Z)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)-N-(4-hydroxyphenyl)prop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099871; BDBM50444603; ZINC15219993; SR-01000218135; SR-01000218135-1
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| Activity | Kallikrein 7 |
Ki = 75000 nM
|
[4] | ||
| Kallikrein 14 |
IC50 = 101000 nM
|
[4] | |||
| Kallikrein 5 |
Ki = 107000 nM
|
[4] | |||
| Compound Name |
N-[(Z)-3-[[(3R,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-oxo-1-pyridin-3-ylprop-1-en-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2087345; BDBM50391077
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|
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| Activity | Kallikrein 7 |
Ki = 75100 nM
|
[12] | ||
| Kallikrein 5 |
Ki = 200000 nM
|
[12] | |||
| Compound Name |
N-[(Z)-3-[[(3R,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-(1,3-benzodioxol-5-yl)-3-oxoprop-1-en-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2087344; BDBM50391076
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|
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| Activity | Kallikrein 7 |
Ki = 80300 nM
|
[12] | ||
| Kallikrein 5 |
Ki = 357100 nM
|
[12] | |||
| Compound Name |
(13S)-13-Benzyl-11-(2,5-dimethoxyphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408419; BDBM50073229
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|
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| Activity | Kallikrein 7 |
IC50 = 80900 nM
|
[8] | ||
| Compound Name |
{1-[1-(4-Amino-1-formyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143643; CHEMBL176386; BDBM50013002
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|
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| Activity | Kallikrein 1 |
IC50 = 82400 nM
|
[10] | ||
| Compound Name |
(5E)-5-(3,4-Dimethoxybenzylidene)-3-{[(5-fluoro-2-methylphenyl)amino]methyl}-1,3-thiazolidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099882; HMS591L04; BDBM50444597; ZINC16677485; BIM-0030827.P001; AB00095447-01
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| Activity | Kallikrein 7 |
Ki = 83000 nM
|
[4] | ||
| Kallikrein 5 |
Ki = 95000 nM
|
[4] | |||
| Kallikrein 14 |
IC50 = 112000 nM
|
[4] | |||
| Compound Name |
(13S)-13-Benzyl-11-(2,4-dimethylphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408416; BDBM50073233
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| Activity | Kallikrein 7 |
IC50 = 83900 nM
|
[8] | ||
| Compound Name |
N-[(2R)-3-(3-Aminopropylsulfanyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907778; BDBM50366643
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|
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| Activity | Kallikrein 1 |
Ki = 87000 nM
|
[13] | ||
| Compound Name |
N-[(2R)-3-(3-Aminopropylsulfanyl)-1-[4-(2-hydroxyethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907779; BDBM50366642
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| Activity | Kallikrein 1 |
Ki = 87000 nM
|
[13] | ||
| Compound Name |
2-(4-{(1Z)-2-Cyano-2-[N-(3-ethoxyphenyl)carbamoyl]vinyl}-2-methoxyphenoxy)acet ic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099875; ZINC5059113; BDBM50444599; AKOS024279048; ST025143; SR-01000222996; SR-01000222996-1
Click to Show/Hide
|
||||
| Activity | Kallikrein 14 |
IC50 = 87000 nM
|
[4] | ||
| Kallikrein 7 |
Ki = 95000 nM
|
[4] | |||
| Compound Name |
N-[3-(1,3-Benzothiazol-2-yl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39375; BDBM50090231
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 92000 nM
|
[13] | ||
| Compound Name |
(13R)-13-Benzyl-11-(2-methylphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408410; BDBM50073232
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 95900 nM
|
[8] | ||
| Compound Name |
4-(4-Guanidinobenzoyloxy)phenylacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Foy 251; 4-GBCE (methanesulfonate); 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt; CHEMBL433135; Foy-251; {4-[(4-carbamimidamidobenzoyl)oxy]phenyl}acetic acid methanesulfonate(1:1); FOY 251Camostat metabolite; SCHEMBL1649708; SCHEMBL11417275; CTK8D7311; DTXSID20991365; HY-19727A; CS-0016501; FT-0668867
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
(S)-1-(9-Hydroxy-9H-3-aza-fluorene-9-carbonyl)-pyrrolidine-2-carboxylic acid 2-aminomethyl-5-chloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372449; BDBM50164263
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki ~ 100000 nM
|
[15] | ||
| Compound Name |
1-{2-[(4-Chlorophenyl)amino]-2-oxoethyl}-N-(1-isopropylpiperidin-4-YL)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-carboxyindole 27; 2-Carboxyindole Scaffold 45; CHEMBL368238; SCHEMBL1675077; BDBM12400; DB07974; Q27097204; N-(4-Chlorophenyl)-2-(1-isopropyl-4-piperidinylcarbamoyl)-1H-indole-1-acetamide
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki ~ 100000 nM
|
[16] | ||
| Compound Name |
1H-Indole-1-acetamide,N-(5-chloro-2-pyridinyl)-2-[[[1-(1-methylethyl)-4-piperidinyl]amino]carbonyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-carboxyindole 29; CHEMBL182597; SCHEMBL1675122; BDBM15867; ZINC14959798; 1-[2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamide
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki ~ 100000 nM
|
[16] | ||
| Compound Name |
2-[[(E)-3-[4-(4-Carbamimidoylphenoxy)carbonylphenyl]-2-methylprop-2-enoyl]-prop-2-enylamino]acetic acid;methanesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85154; SCHEMBL5574445
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
Methyl N-[3-[(2S)-1-[(2R)-2-(3-carbamoylanilino)-2-(3,4-dimethoxyphenyl)acetyl]pyrrolidin-2-yl]-4-propan-2-ylsulfonylphenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947087; BDBM50201265
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki ~ 100000 nM
|
[17] | ||
| Compound Name |
2-Carboxyindole 17
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181849; SCHEMBL1675180; BDBM15857; 1-[(6-chloro-1-benzothiophen-2-yl)methyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamide; 1-[(6-chloro-1-benzothiophen-2-yl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki ~ 100000 nM
|
[16] | ||
| Compound Name |
Chembl4202971
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459533
Click to Show/Hide
|
||||
| Activity | Kallikrein 6 |
IC50 = 110000 nM
|
[7] | ||
| Compound Name |
(E)-3-[3-[(4-Chlorophenoxy)methyl]-4-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099883; ZINC5102252; BDBM50444596
Click to Show/Hide
|
||||
| Activity | Kallikrein 14 |
IC50 = 122000 nM
|
[4] | ||
| Compound Name |
(13S)-13-Benzyl-11-(3-hydroxyphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408430; BDBM50073227
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 124800 nM
|
[8] | ||
| Compound Name |
2-[[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-[2-(4-methoxyphenyl)acetyl]amino]-N-cyclohexyl-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963267; BDBM50205624
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
IC50 = 125000 nM
|
[18] | ||
| Compound Name |
2-[[(3S,3Ar,6S,6aR)-6-[[1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl]-[2-(4-hydroxyphenyl)acetyl]amino]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-[2-(4-hydroxyphenyl)acetyl]amino]-N-cyclohexyl-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901491; BDBM50205625
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 133000 nM
|
[18] | ||
| Compound Name |
N-[(2S)-1-(2-Aminoimidazo[1,2-a]pyridin-3-yl)-1-oxo-3-phenylpropan-2-yl]-2-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408439; BDBM50073226
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 135400 nM
|
[8] | ||
| Compound Name |
N-[(2S)-1-(2-Aminoimidazo[1,2-a]pyridin-3-yl)-1-oxo-3-phenylpropan-2-yl]-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408441; BDBM50073224
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 149200 nM
|
[8] | ||
| Compound Name |
N-[(2R)-1-[[2-[[1-[4-(Diaminomethylideneamino)phenyl]-4,4,4-trifluoro-3-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]morpholine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160803
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki ~ 150000 nM
|
[5] | ||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109059; BDBM50446230
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 156900 nM
|
[11] | ||
| Compound Name |
Benzyl (2S)-2-[[(2S)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109171; BDBM50446213
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 157400 nM
|
[11] | ||
| Compound Name |
Chembl4211470
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZINC9670559; BDBM50459513; AKOS001221230; MCULE-9165584447
Click to Show/Hide
|
||||
| Activity | Kallikrein 6 |
IC50 = 170000 nM
|
[7] | ||
| Compound Name |
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567134; MLS002471787; SCHEMBL3353019; HMS2198O14; BDBM50303441; NCGC00182110-01; NCGC00182110-02; SMR001395200; Q27165373; 9-(3,5-difluorophenyl)-6-(ethylamino)purine-2-carbonitrile; 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity | Kallikrein 4 |
IC50 = 177827.94 nM
|
[19] | ||
| Compound Name |
2-[[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-[2-(4-fluorophenyl)acetyl]amino]-N-cyclohexyl-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951954; BDBM50205623
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 185000 nM
|
[18] | ||
| Compound Name |
1-Adamantyl N-[(2R)-1-[[(2S)-1-[[1-[4-(diaminomethylideneamino)phenyl]-4,4,4-trifluoro-3-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160809
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 191000 nM
|
[5] | ||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[1-(diaminomethylideneamino)-5,8-dioxo-8-piperidin-1-yloctan-4-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202120
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 199000 nM
|
[20] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 33 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-((3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)amino)-2-oxoethyl 2-(2-methyl-1H-indol-3-yl)acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DKFZ-251; CHEMBL4218203; SCHEMBL20037008; GTPL10575; TQP0912; BDBM50459538; compound 11 [PMID: 30212625]; [2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-(2-methyl-1H-indol-3-yl)acetate
Click to Show/Hide
|
||||
| Activity | Kallikrein 4 |
IC50 > 200000 nM
|
[7] | ||
| Compound Name |
Chembl4214840
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459519
Click to Show/Hide
|
||||
| Activity | Kallikrein 6 |
IC50 > 200000 nM
|
[7] | ||
| Compound Name |
Chembl4210437
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459521
Click to Show/Hide
|
||||
| Activity | Kallikrein 6 |
IC50 > 200000 nM
|
[7] | ||
| Compound Name |
Chembl4207321
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459517; AKOS006617928
Click to Show/Hide
|
||||
| Activity | Kallikrein 6 |
IC50 > 200000 nM
|
[7] | ||
| Compound Name |
2-[[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-[2-(4-fluorophenyl)acetyl]amino]-N-cyclohexyl-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951954; BDBM50205623
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
IC50 = 221000 nM
|
[18] | ||
| Compound Name |
[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2R)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109159; BDBM50446225
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 222900 nM
|
[11] | ||
| Kallikrein 7 |
IC50 = 239000 nM
|
[11] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(1S)-2-[[1-[4-(diaminomethylideneamino)phenyl]-4,4,4-trifluoro-3-oxobutan-2-yl]amino]-1-naphthalen-2-yl-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160808
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 223000 nM
|
[5] | ||
| Compound Name |
2-[[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-[2-(4-hydroxyphenyl)acetyl]amino]-N-cyclohexyl-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943212; BDBM50205620
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 249000 nM
|
[18] | ||
| Compound Name |
Benzyl (2S)-2-[[(2S)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109171; BDBM50446213
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 249300 nM
|
[11] | ||
| Compound Name |
2-[[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-[2-(4-methoxyphenyl)acetyl]amino]-N-cyclohexyl-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963267; BDBM50205624
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 272000 nM
|
[18] | ||
| Compound Name |
Benzyl (2R)-2-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]carbamoyl]pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109057; BDBM50446212
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 320600 nM
|
[11] | ||
| Compound Name |
[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109161; BDBM50446223
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 356600 nM
|
[11] | ||
| Compound Name |
[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2R)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109162; BDBM50446222
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 376600 nM
|
[11] | ||
| Compound Name |
N-[(3S,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]-N-[1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891631; BDBM50205621
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
IC50 = 400000 nM
|
[18] | ||
| Kallikrein 7 |
IC50 = 572000 nM
|
[18] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109170; BDBM50446214
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 418300 nM
|
[11] | ||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109169; BDBM50446215
Click to Show/Hide
|
||||
| Activity | Kallikrein 7 |
IC50 = 456800 nM
|
[11] | ||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109167; BDBM50446217
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 479800 nM
|
[11] | ||
| Kallikrein 7 |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
2-O-[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] 1-O-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109158; BDBM50446226
Click to Show/Hide
|
||||
| Activity | Kallikrein 5 |
IC50 = 520700 nM
|
[11] | ||
| Compound Name |
Chembl432400
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370338; BDBM50079381
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 630000 nM
|
[21] | ||
| Compound Name |
4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107627; BDBM50060035
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
Mupain-1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734777; BDBM50499239
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[23] | ||
| Compound Name |
3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322901; BDBM50060029
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-3-oxo-2-(2,2,5,7,8-pentamethyl-chroman-6-sulfonylamino)-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107743; BDBM50060019
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107282; BDBM50060024
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322165; BDBM50060023
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
3-[(R)-2-[2-(7,7-Dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-ethanesulfonylamino]-3-(4-methanesulfonyl-piperazin-1-yl)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319035; BDBM50060046
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-11-(carboxymethyl)-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735080; BDBM50499240
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[23] | ||
| Compound Name |
3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107911; BDBM50060031
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107392; BDBM50060017
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 1000000 nM
|
[22] | ||
| Compound Name |
6-Amino-N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927450; BDBM50359553
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 1300000 nM
|
[24] | ||
| Compound Name |
N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(Aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927307; BDBM50359552
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki = 1800000 nM
|
[24] | ||
| Compound Name |
N-[(2R)-1-[[(2S)-1-[[1-[4-(Diaminomethylideneamino)phenyl]-4,4,4-trifluoro-3-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]morpholine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160804
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 2500000 nM
|
[5] | ||
| Compound Name |
3-[Bis(6-aminohexyl)amino]tetrahydro-4H-thiopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318854; BDBM50079380; 3-[Bis-(6-amino-hexyl)-amino]-tetrahydro-thiopyran-4-one
Click to Show/Hide
|
||||
| Activity | Kallikrein 1 |
Ki > 10000000 nM
|
[21] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 9 | Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6112-5. | ||||
| REF 10 | New leupeptin analogues: synthesis and inhibition data. J Med Chem. 1990 Jan;33(1):86-93. | ||||
| REF 11 | Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7. ACS Med Chem Lett. 2013 Dec 6;5(2):128-32. | ||||
| REF 12 | Isomannide derivatives as new class of inhibitors for human kallikrein 7. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6072-5. | ||||
| REF 13 | The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1563-6. | ||||
| REF 14 | New orally active serine protease inhibitors. J Med Chem. 1995 Jul 7;38(14):2521-3. | ||||
| REF 15 | 9-hydroxyazafluorenes and their use in thrombin inhibitors. J Med Chem. 2005 Apr 7;48(7):2282-93. | ||||
| REF 16 | Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4191-5. | ||||
| REF 17 | Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors. ACS Med Chem Lett. 2016 Sep 17;7(12):1077-81. | ||||
| REF 18 | Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor. Bioorg Med Chem Lett. 2017 Jan 15;27(2):314-318. | ||||
| REF 19 | Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. | ||||
| REF 20 | Synthesis and biological activity of ketomethylene pseudopeptide analogues as thrombin inhibitors. J Med Chem. 1992 Sep 4;35(18):3364-9. | ||||
| REF 21 | 4-Heterocyclohexanone-based inhibitors of the serine protease plasmin. J Med Chem. 1999 Jul 29;42(15):2969-76. | ||||
| REF 22 | Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine. J Med Chem. 1997 Sep 12;40(19):3091-9. | ||||
| REF 23 | Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. J Med Chem. 2015 Nov 25;58(22):8868-76. | ||||
| REF 24 | The arginine mimicking -amino acid hPhe(3-H1 -CH1 as S1 ligand in cyclotheonamide-based -tryptase inhibitors. Bioorg Med Chem. 2011 Dec 1;19(23):7236-43. | ||||
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