Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57253 | Target Info | |||
| Target Name | Mas-related G protein-coupled receptor X1 (MRGX1) | ||||
| Synonyms |
Sensory neuron-specific G-protein coupled receptor 3/4; SNSR4; SNSR3; Mas-related G-protein coupled receptor member X1; MRGX1
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| Target Type | Literature-reported Target | ||||
| Gene Name | MRGPRX1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
RF9
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Investigative | Compound Info | ||
| Synonyms |
1-Adamantanecarbonyl-RF-NH2
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[2-Amino-2-(1-carbamimidoylpiperidin-4-yl)acetyl]amino]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343988; BDBM50497460
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1632140-61-4 (Free base)
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Investigative | Compound Info | ||
| Synonyms |
JHU-58; CHEMBL3343994; (R)-2-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-3-(4-guanidinophenyl)propanamide; BDBM50497458
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-3-[4-(diaminomethylideneamino)phenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343993; BDBM50497464
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[2-Amino-2-[3-(diaminomethylideneamino)phenyl]acetyl]amino]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343992; BDBM50497459
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-4-[(diaminomethylideneamino)methyl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343991; BDBM50497463
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-4-(diaminomethylideneamino)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343987; BDBM50497462
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Arginylphenylalaninamide
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Investigative | Compound Info | ||
| Synonyms |
Rfamide; H-Arg-Phe-NH2; CHEMBL3343990; (S)-2-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide; arginyl-phenylalanine amide; SCHEMBL1373212; L-Phenylalaninamide, L-arginyl-; DTXSID20955942; ZINC2554967; BDBM50497461
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem. 2014 Nov 1;22(21):5831-7. | ||||
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