Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56871 | Target Info | |||
| Target Name | Lysine-specific demethylase 5B (KDM5B) | ||||
| Synonyms |
Retinoblastomabinding protein 2 homolog 1; Retinoblastoma-binding protein 2 homolog 1; RBP2H1; RBP2-H1; RBBP2H1; PLU1; PLU-1; Lysinespecific demethylase 5B; Jumonji/ARID domaincontaining protein 1B; Jumonji/ARID domain-containing protein 1B; JARID1B; Histone demethylase JARID1B; Cancer/testis antigen 31; CT31
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| Target Type | Literature-reported Target | ||||
| Gene Name | KDM5B | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(4-Pyridin-2-yl-thiazol-2-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL164087; N-(4-Pyridin-2-yl-thiazol-2-yl)-benzamide; AC1N3WC4; N-(4-pyridin-2-yl-1,3-thiazol-2-yl)benzamide; Oprea1_401409; MolPort-004-132-922; BDBM50097430; AKOS017070888; N-[4-(2-pyridyl)thiazol-2-yl]benzamide
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| Activity |
IC50 = 51200 nM
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[1] | |||
| Compound Name |
3-(Ethanesulfonyl)-N-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
TCMDC-142704; CHEMBL2098408; GSK1073647A; ZINC4304968; BDBM50153158; AKOS002051944; MCULE-8617902642; Z1541780606
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| Activity |
IC50 = 52600 nM
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[1] | |||
| Compound Name |
8-(Piperidin-1-ylmethyl)-3H-pyrido[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774418; BDBM50153150
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| Activity |
IC50 = 66000 nM
|
[1] | |||
| Compound Name |
2-(5-Acetamido-2-Oxidanyl-Phenyl)pyridine-4-Carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774598; S2X; BDBM50151401
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| Activity |
IC50 = 72000 nM
|
[2] | |||
| Compound Name |
2-Hydrazinylpyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793278; SCHEMBL18943862; BDBM50163389
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1388-409. | ||||
| REF 2 | Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1580-98. | ||||
| REF 3 | Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis. Bioorg Med Chem Lett. 2016 May 1;26(9):2284-8. | ||||
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