Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56057 | Target Info | |||
| Target Name | Lysine-specific demethylase 6B (KDM6B) | ||||
| Synonyms |
Lysine demethylase 6B; KIAA0346; Jumonji domain-containing protein 3; JmjC domain-containing protein 3; JMJD3
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | KDM6B | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 50 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
daminozide
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|
Investigative | Compound Info | ||
| Synonyms |
DMASA; SADH; B 995; Alar; Kylar; B-NINE
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[1-(2-Phenylacetyl)pyrrolidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621873; BDBM50498683
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Propanoylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621866; BDBM50498670
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Propanoylpiperidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621876; BDBM50498682
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
Potassium;2-[1-(3-methylphenyl)triazol-4-yl]pyridine-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621855; BDBM50498681
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
3-Aminoisonicotinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
3-aminopyridine-4-carboxylic acid; 3-Amino-4-pyridinecarboxylic acid; 3-Amino-isonicotinic acid; 3-Amino-4-Pyridine Carboxylic Acid; 4-Pyridinecarboxylic acid, 3-amino-; 3-amino isonicotinic acid; MFCD00137840; CHEMBL1383671; 3-Amino-4-pyridinecarboxylicacid; 3-Aminoisonicotinic acid, 98%; 3-Aminoisonicotinicacid; 3-Amino-4-carboxypyridine; PubChem2420; 3-Aminoisonicotinsaure; PubChem16665; 3-aminoisonicotinoic acid; 3-arninoisonicotinic acid; C2147; ACMC-1BHX3; EC-000.1274; Oprea1_716398; KSC497Q5J; MLS000736244; SCHEMBL535569; CTK3J7854; HMS2627H07; ZINC165882; 3-amino-pyridine-4-carboxylic acid; ACT02413; ACT04453; ALBB-008671; BCP09357; BCP27886; CS-D0792; KS-000003GS; ANW-36670; BDBM50122002; HT1060; RW3867; SBB002130; STK505487; WT2006; AKOS005070462; AC-2913; ACN-028423; LS20439; MCULE-9282322392; PB17122; QC-3267; VP15197; 7529-20-6 3-Aminoisonicotinic acid; 3-Aminopyridine-4-carboxylic acid, 95%; AK-23678; BP-11256; BR-23678; SC-06649; SMR000338494; ST091022; SY003330; 3-AMINO-4-CARBOXYLIC ACID PYRIDINE; AB0001899; DB-006331; DB-031885; A9601; A9626; AM20070278; BB 0260163; FT-0601258; FT-0648899; EN300-40529; 4K-902; A-1734; 7529-20-6 3-Aminopyridine-4-carboxylic acid; 529A206; AC-907/25000242; J-400348; J-511628; Q27454941; Z1741962538
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| Activity |
IC50 = 63095.73 nM
|
[3] | |||
| Compound Name |
2-[1-(1-Propanoylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621860; BDBM50498668
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|
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| Activity |
IC50 = 63095.73 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Butanoylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621867; BDBM50498664
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|
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| Activity |
IC50 = 63095.73 nM
|
[2] | |||
| Compound Name |
Methyl 2-[4-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]pyridin-2-yl]pyridine-4-carboxylate;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3108959; BDBM50495471
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|
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| Activity |
IC50 = 76000 nM
|
[4] | |||
| Compound Name |
2-[1-(2-Phenylethyl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621857; BDBM50498689
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| Activity |
IC50 = 79432.82 nM
|
[2] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)pyrrolidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621874; BDBM50498674
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|
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| Activity |
IC50 = 79432.82 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Butanoylpiperidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621877; BDBM50498677
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|
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| Activity |
IC50 = 79432.82 nM
|
[2] | |||
| Compound Name |
2-[1-(2-Phenoxyethyl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621858; BDBM50498688
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|
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| Activity |
IC50 = 79432.82 nM
|
[2] | |||
| Compound Name |
Tetrazole-5-acetohydrazide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785434; 2H-Tetrazole-5-acetic acid, hydrazide; KS-00000E3R; 2-(2H-tetrazol-5-yl)acetohydrazide; 7364AJ; BDBM50158850; MFCD18071020; ZINC90613053; AKOS006340922; MCULE-5629806431; AS-31945; SY011683; (1H-Tetrazole-5-yl)acetic acid hydrazide; 2-(1h-tetrazol-5-yl)acetic acid hydrazide; DB-058328; FT-0718023
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| Activity |
IC50 = 98000 nM
|
[5] | |||
| Compound Name |
2-[1-(1-Butanoylpyrrolidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621871; BDBM50498678
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(5-Acetamido-2-Oxidanyl-Phenyl)pyridine-4-Carboxylic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774598; S2X; BDBM50151401
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(4-Chloro-3-hydroxyphenoxy)-3H-pyrido[3,4-d]pyrimidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770740; BDBM50149925
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[1-(1-Acetylpiperidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621875; BDBM50498671
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|
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
Potassium;2-(1-benzyltriazol-4-yl)pyridine-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621856; BDBM50498672
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)piperidin-4-yl]triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621864; BDBM50498685
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Ethoxycarbonylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621859; BDBM50498669
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Benzoylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621868; BDBM50498676
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|
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
3-[[4-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-6-indazol-2-ylpyrimidin-2-yl]amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752471; BDBM50140351
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|
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Hydrazinylpyrimidine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793278; SCHEMBL18943862; BDBM50163389
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[1-(1-Butanoylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621861; BDBM50498692
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(Isopropylamino)-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164248; N-isopropylsuccinamic acid; 3-(propan-2-ylcarbamoyl)propanoic acid; NSC56468; 4-oxo-4-(propan-2-ylamino)butanoic acid; Butanoic acid, 4-[(1-methylethyl)amino]-4-oxo-; SCHEMBL94233; CTK2F3983; DTXSID20288540; ALBB-033190; ZINC1687428; BDBM50395081; MFCD02675045; NSC-56468; AKOS002675066; 4-Oxo-4-(isopropylamino)butanoic acid; MCULE-6515821068
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(1-Benzyl-1h-Pyrazol-4-Yl)oxy]pyrido[3,4-D]pyrimidin-4(3h)-One
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|
Investigative | Compound Info | ||
| Synonyms |
GSK467; GSK 467; 2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one; cGAS inhibitor 467; CHEMBL3771180; SCHEMBL16082705; SCHEMBL17503725; GSK-467; GSK467; GSK 467; BCP30840; BS-15947; HY-116761; CS-0066471; J3.601.422I; Q27460958; 2-(1-benzylpyrazol-4-yl)oxy-1H-pyrido[3,4-d]pyrimidin-4-one; 2-[(1-benzyl-1H-pyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4-ol; 2-(1-Benzyl-1H-pyrazole-4-yloxy)-3,4-dihydropyrido[3,4-d]pyrimidine-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[1-(Cyclohexylmethyl)-1H-pyrazole-4-yloxy]-3,4-dihydropyrido[3,4-d]pyrimidine-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3771198; BDBM50149917; J3.601.421K
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Potassium;2-(1-ethyltriazol-4-yl)pyridine-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621854; BDBM50498691
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(1-Benzylpyrazol-4-yl)oxy-3H-pyrido[2,3-d]pyrimidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770732; SCHEMBL16082706; BDBM50149911
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Pyridinecarboxylic acid, 3-[(3-aminopropyl)amino]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774560; SCHEMBL15286471; BDBM50153345; ZINC84455187; DA-25288; FT-0738287; 3-(3-aminopropylamino)pyridine-4-carboxylic acid
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)azetidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621870; BDBM50498684
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[(1-Cyclopentylpyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3769724; SCHEMBL17503718; BDBM50149920; J3.601.420B; 2-(1-Cyclopentyl-1H-pyrazole-4-yloxy)-3,4-dihydropyrido[3,4-d]pyrimidine-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3-Carboxypropanoylamino)-trimethylazanium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164244; BDBM50395079
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Benzamidopyridine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774975; 3-benzamidoisonicotinic acid; BDBM50153344; ZINC83753862; AKOS013717144; DA-24121; FT-0730406; Z2472759342
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[1-[(3R)-1-Benzoylpiperidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621881; BDBM50498675; 2-[1-(1-Benzoylpiperidine-3alpha-yl)-1H-1,2,3-triazole-4-yl]pyridine-4-carboxylic acid
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'1,N'1,N'4,N'4-Tetramethylsuccinohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164250; SCHEMBL584428; Succinic acid dimethyl hydrazide; BDBM50395077; AKOS002685593; MCULE-9315956570
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[1-(2-Phenylacetyl)azetidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621869; BDBM50498693
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Hydrazinyl-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
succinic acid Monohydrazide; Butanedioic acid, monohydrazide; CHEMBL2164246; 4-diazanyl-4-oxidanylidene-butanoic acid; NSC9925; ACMC-20d2l3; SCHEMBL960529; CTK1D8820; DTXSID10278758; 3-(hydrazinecarbonyl)propanoic acid; NSC-9925; ZINC1700248; BDBM50395083; AKOS006379804
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2h-1,2,3-Triazol-4-Yl)pyridine-4-Carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621851; BDBM50498662; Q27462440; LEL
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2-Methylhydrazinyl)-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164245; succinic acid 2,2-methylhydrazide; BDBM50395078
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(3-Methylthiophen-2-yl)methylamino]pyridine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774435; BDBM50153321
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-[Dimethylamino(methyl)amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164247; BDBM50395082
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Quinolinecarboxylic acid, 8-hydroxy-, octyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785984; cmp5;compound 5; BDBM50158888
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Tranylcypromine hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
trans-2-Phenylcyclopropanamine hydrochloride; trans-2-Phenylcyclopropylamine hydrochloride; (1R,2S)-2-phenyl-cyclopropylamine hydrochloride; 2-PCPA Hydrochloride; (1R,2S)-2-Phenylcyclopropanamine hydrochloride; (1R,2S)-tranylcypromine hydrochloride; (1R,2S)-2-phenylcyclopropan-1-amine hydrochloride; TRANS-2-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE; trans-2-Phenylcyclopropylamine HCl; Tranylcypromine (2-PCPA) HCl; DSSTox_CID_27761; DSSTox_RID_82538; DSSTox_GSID_47781; Tranylcypromine HCl; SMR000875332; (2S,1R)-2-phenylcyclopropylamine, chloride; C9H11N.HCl; 2-Phenyl-Cyclopropylamine HCl; (+)-Tranylcypromine Hydrochloride; 2-PCPA; Tranylcypromine (2-PCPA) hydrochloride; trans-2-phenylcyclopropan-1-amine hydrochloride; Rel-Tranylcypromine HCl; trans-2-Phenylcyclopropylamine hydrochloride, 97%; NCGC00016598-01; SCHEMBL56351; KSC493A7B; MLS001335868; MLS002153363; D-tranylcypromine hydrochloride; Cyclopropanamine, 2-phenyl-, hydrochloride (1:1), (1R,2S)-rel-; CHEMBL1255743; DTXSID6047781; CTK3J3070; Cyclopropanamine, 2-phenyl-, hydrochloride, (1R,2S)-rel-; HMS1568D07; Tox21_110514; 8373AH; MFCD00063602; MFCD17976456; SBB003859; AKOS022185792; Tox21_110514_1; AM84681; DS-6561; NE64568; SB35126; SB36889; KS-000005F7; NCGC00016598-02; B7514; ST50406162; (trans)-2-phenylcyclopropanamine hydrochloride; (1R,2S)-2-phenylcyclopropan-1-aminium chloride; (+/-)-Trans-2-phenyl-cyclopropylamine hydrochloride; (+/-)-trans-2-Phenylcyclopropylamine hydrochloride; J-640402; J-800286; trans-(+/-)-2-phenyl-cyclopropylamine hydrochloride; trans-(+/-)-2-Phenylcyclopropylamine hydrochloride; Q27225148; UNII-7H4CZX4FYH component ZPEFMSTTZXJOTM-OULXEKPRSA-N
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Potassium;2-(1-methyltriazol-4-yl)pyridine-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621853; BDBM50498690
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Pyridinecarboxylic acid, 3-[(2-aminoethyl)amino]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775366; BDBM50153346
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[5-(2-Methoxyethanoylamino)-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775380; 7WH; BDBM50151399
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[1-(1-Acetylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621865; BDBM50498661
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Chloro-7-[benzoylamino(3-methyl-2-thienyl)methyl]-8-quinolinol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785164; BDBM50158849
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|
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| Activity |
IC50 = 106000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. | ||||
| REF 2 | Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. Medchemcomm. 2014 Dec 1;5(12):1879-1886. | ||||
| REF 3 | Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J Med Chem. 2016 Feb 25;59(4):1370-87. | ||||
| REF 4 | Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem. 2014 Jan 9;57(1):42-55. | ||||
| REF 5 | Recent Progress in Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1308-29. | ||||
| REF 6 | Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1580-98. | ||||
| REF 7 | Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors. Bioorg Med Chem Lett. 2016 Feb 1;26(3):721-725. | ||||
| REF 8 | Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis. Bioorg Med Chem Lett. 2016 May 1;26(9):2284-8. | ||||
| REF 9 | Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives. J Med Chem. 2016 Feb 25;59(4):1357-69. | ||||
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