Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T55729 | Target Info | |||
| Target Name | Stress-activated protein kinase 2b (p38 beta) | ||||
| Synonyms |
Stress-activated protein kinase-2; SAPK2b; SAPK2; PRKM11; P38b; P38-2; P38 Mitogen-activated protein kinase beta; Mitogen-activated protein kinase p38 beta; Mitogen-activated protein kinase 11; MAPK 11; MAP kinase p38 beta; MAP kinase 11
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPK11 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3r)-1-{2-[4-(4-Acetylphenyl)piperazin-1-Yl]-2-Oxoethyl}-N-(3-Chloro-4-Hydroxyphenyl)pyrrolidine-3-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356117; SCHEMBL7878839; BDBM50030881; Q27453793
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Cyclapolin 9
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Investigative | Compound Info | ||
| Synonyms |
Cyclapolin-9; CHEMBL476124; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide; 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide; SCHEMBL5055142; CTK8I6133; AOB5979; ZINC2577648; BDBM50263697; AKOS024457436; HY-15159; CS-0003792; 7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide; 2-(aminocarbonyl)-7-nitro-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-3-olate
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide
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Investigative | Compound Info | ||
| Synonyms |
Cyclapolin 1; 2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-3-oxide; SCHEMBL5062617; CHEMBL1222044; CTK2H1083; DTXSID10429521; 7-nitro-3-oxido-5-(trifluoromethylsulfanyl)-1,3-benzothiazol-3-ium-2-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase. J Med Chem. 2014 Nov 13;57(21):8817-26. | ||||
| REF 2 | Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. | ||||
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