Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53585 | Target Info | |||
| Target Name | HMG-CoA reductase (HMGCR) | ||||
| Synonyms |
3-hydroxy-3-methylglutaryl-coenzyme A reductase
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| Target Type | Successful Target | ||||
| Gene Name | HMGCR | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Isoleucyl-L-valyl-L-alanyl-L-glutamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261748; CTK3G2421; DTXSID10648937; BDBM50226169; L-Glutamic acid, L-isoleucyl-L-valyl-L-alanyl-
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| Activity |
IC50 = 52670 nM
|
[1] | |||
| Compound Name |
(4R,6S)-6-[(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)sulfanylquinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595988; BDBM50304652
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| Activity |
IC50 = 62400 nM
|
[2] | |||
| Compound Name |
L-Isoleucyl-L-alanyl-L-valyl-L-glutamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259240; CTK3G2423; DTXSID70648933; BDBM50226171; L-Glutamic acid, L-isoleucyl-L-alanyl-L-valyl-
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| Activity |
IC50 = 75230 nM
|
[1] | |||
| Compound Name |
Iavptgva
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163198; Ile-Ala-Val-Pro-Thr-Gly-Val-Ala; BDBM50321111; J3.595.387F; L-Ile-L-Ala-L-Val-L-Pro-L-Thr-Gly-L-Val-L-Ala-OH
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| Activity |
IC50 = 152190 nM
|
[1] | |||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Iavpgeva
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260510; Ile-Ala-Val-Pro-Gly-Glu-Val-Ala; BDBM50226173; J3.595.386H; L-Ile-L-Ala-L-Val-L-Pro-Gly-L-Glu-L-Val-L-Ala-OH
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|
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| Activity |
IC50 = 201120 nM
|
[1] | |||
| Compound Name |
(4R,6S)-6-((E)-2-(2-Cyclopropyl-6,7-difluoro-4-(3-methoxyphenylthio)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595754; BDBM50304658
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| Activity |
IC50 = 359600 nM
|
[2] | |||
| Compound Name |
alpha,beta-Dehydrmonacolin S
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986260; BDBM50191275; J3.549.604A
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| Activity |
IC50 = 387000 nM
|
[3] | |||
| Compound Name |
L-Leucyl-L-prolyl-L-tyrosyl-L-proline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL412060; CTK3C3369; DTXSID90659167; L-Leu-L-Pro-L-Tyr-L-Pro-OH; BDBM50226159; L-Proline, L-leucyl-L-prolyl-L-tyrosyl-; J3.595.388D
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| Activity |
IC50 = 484720 nM
|
[1] | |||
| Compound Name |
(4R,6S)-6-((E)-2-(2-Cyclopropyl-6,7-difluoro-4-(4-isopropylphenylthio)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595984; BDBM50304659
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|
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| Activity |
IC50 = 759000 nM
|
[2] | |||
| Compound Name |
7-[(1S,2S,6S)-6-(2,2-Dimethylpropanoyloxymethyl)-2-methylcyclohex-3-en-1-yl]-3,5-dihydroxyheptanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149701; BDBM50391273
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|
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| Activity |
IC50 = 1500000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase. Bioorg Med Chem. 2010 Jun 15;18(12):4300-9. | ||||
| REF 2 | Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. Bioorg Med Chem. 2009 Dec 1;17(23):7915-23. | ||||
| REF 3 | Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178. J Nat Prod. 2016 Jun 24;79(6):1500-7. | ||||
| REF 4 | C-2 desmethyl seco-mevinic acids. Monocyclic HMG-CoA reductase inbibitors. Bioorg Med Chem Lett. 1991;1(10):509-12. | ||||
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